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Index > Protein center > Cacna1h(Gene name) > Mouse
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  • Cacna1h (Gene name),
  • Voltage-dependent T-type calcium channel subunit alpha-1H (Protein name ),  CAC1H_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    Cacna1h(Kiaa1120);
    Protein name:
    Voltage-dependent T-type calcium channel subunit alpha-1H;
    Alternative:
    Voltage-gated calcium channel subunit alpha Cav3.2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    2365
    Sequence:
    50:
    MTEGTLAADE | VRVPLGASPS | APAAPVRASP | ASPGVPGREE | QRGSGSSVLA | 
    100:
    PESPGTECGA | DLGADEEQPV | PYPALAATVF | FCLGQTTRPR | SWCLRLVSRR | 
    150:
    WFEHISMLVI | MLNCVTLGMF | RPCEDVECRS | ERCSILEAFD | DFIFAFFAVE | 
    200:
    MVIKMVALGL | FGQKCYLGDT | WNRLDFFIVM | AGMMEYSLDG | HNVSLSAIRT | 
    250:
    VRVLRPLRAI | NRVPSMRILV | TLLLDTLPML | GNVLLLCFFV | FFIFGIVGVQ | 
    300:
    LWAGLLRNRC | FLDSAFVRNN | NLTFLRPYYQ | TEEGEENPFI | CSSRRDNGMQ | 
    350:
    KCSHIPSRRE | LRVQCTLGWE | AYGQPQAEDG | GAGRNACINW | NQYYNVCRSG | 
    400:
    EFNPHNGAIN | FDNIGYAWIA | IFQVITLEGW | VDIMYYVMDA | HSFYNFIYFI | 
    450:
    LLIIVGSFFM | INLCLVVIAT | QFSETKQREN | QLMREQRARY | LSNDSTLASF | 
    500:
    SEPGSCYEEL | LKYVGHIFRK | VKRRSLRLYA | RWQSRWRKKV | DPSSTLHGQG | 
    550:
    PRRRPRRAGR | RTASVHHLVY | HHHHHHHHHY | HFSHGGPRRP | SPEPGAGDTR | 
    600:
    LVRACVPPSP | PSPGHGPPDS | ESVHSIYHAD | CHVEGPQERA | RVAHTIATAA | 
    650:
    SLKLASGLGT | MNYPTILPSG | AVNSKGSTSS | RPKGLRSAGT | PGATAHSPLS | 
    700:
    LGSPSPYEKI | QHVVGEQGLG | RASSHLSGLS | VPCPLPSPQA | GTLTCELKSC | 
    750:
    PYCASALEDP | EFEFSGSESG | DSDAHGVYEF | TQDVRHGDCR | DPVQQPHEGG | 
    800:
    TPGHGNERWR | PPLRTASQPG | GLGRLWASFS | SKLRRIVDSK | YFNRGIMAAI | 
    850:
    LVNTLSMGVE | YHEQPDELTN | ALEISNIVFT | SMFALEMLLK | LLACGPLGYI | 
    900:
    RNPYNIFDGI | VVIISVWEIV | GQADGGLSVL | RTFRLLRVLK | LVRFLPALRR | 
    950:
    QLVVLMRTMD | NVATFCMLLM | LFIFIFSILG | MHLFGCKFSL | KTDSGDTVPD | 
    1000:
    RKNFDSLLWA | IVTVFQILTQ | EDWNVVLYNG | MASTSSWAAL | YFVALMTFGN | 
    1050:
    YVLFNLLVAI | LVEGFQAEGD | ATRSDTDEDK | TSTHLEEDFD | KLRDVQATEM | 
    1100:
    KMYSLAVTPN | GHLEGRGSLP | PPLITHTAAT | PMPTPKSSPH | LDMAHTLLDS | 
    1150:
    RRSSSGSVDP | QLGDQKSLAS | LRSSPCAPWG | PNSAGSSRRS | SWNSLGRAPS | 
    1200:
    LKRRSQCGER | ESLLSGEGKG | STDDEAEDSR | PNSGTHPGAS | PGPRATPLRR | 
    1250:
    AESLGHRSTM | DLCPPRPATL | LPTKFRDCNG | QMVALPSEFF | LRIDSHKEDA | 
    1300:
    AEFDDDIEDS | CCFRLHKVLE | PYAPQWCSSR | ESWALYLFPP | QNRLRVSCQK | 
    1350:
    VIAHKMFDHV | VLVFIFLNCI | TIALERPDID | PGSTERAFLS | VSNYIFTAIF | 
    1400:
    VVEMMVKVVA | LGLLWGEHAY | LQSSWNVLDG | LLVLVSLVDI | IVAVASAGGA | 
    1450:
    KILGVLRVLR | LLRTLRPLRV | ISRAPGLKLV | VETLISSLRP | IGNIVLICCA | 
    1500:
    FFIIFGILGV | QLFKGKFYYC | EGTDTRNITT | KAECHAAHYR | WVRRKYNFDN | 
    1550:
    LGQALMSLFV | LSSKDGWVNI | MYDGLDAVGI | DQQPVQNHNP | WMLLYFISFL | 
    1600:
    LIVSFFVLNM | FVGVVVENFH | KCRQHQEAEE | ARRREEKRLR | RLERRRRSTF | 
    1650:
    PNPEAQRRPY | YADYSHTRRS | IHSLCTSHYL | DLFITFIICL | NVITMSMEHY | 
    1700:
    NQPKSLDEAL | KYCNYVFTIV | FVFEAALKLV | AFGFRRFFKD | RWNQLDLAIV | 
    1750:
    LLSIMGIALE | EIEMNAALPI | NPTIIRIMRV | LRIARVLKLL | KMATGMRALL | 
    1800:
    DTVVQALPQV | GNLGLLFMLL | FFIYAALGVE | LFGRLECSED | NPCEGLSRHA | 
    1850:
    TFTNFGMAFL | TLFRVSTGDN | WNGIMKDTLR | ECTREDKHCL | SYLPALSPVY | 
    1900:
    FVTFVLVAQF | VLVNVVVAVL | MKHLEESNKE | AREDAEMDAE | IELEIAQGST | 
    1950:
    AQPPSTAQES | QGTEPDTPNL | LVVRKVSVSR | MLSLPNDSYM | FRPVAPAAAP | 
    2000:
    HSHPLQEVEM | ETYTGPVTSA | HSPSLEPRTS | FQVPSAASSP | ARVSDPLCAL | 
    2050:
    SPRDTPRSLS | LSRILCRQEA | MHAESLEGQI | DDAGEDSIPD | YTEPAENISM | 
    2100:
    SQAPLGTLRS | PPCSPRPASV | RTRKHTFGQH | CISSRPPTLG | GDDAEAADPA | 
    2150:
    DEEVSHITSS | AHPWPATEPH | SPEASPTASP | AKGTVGSGRD | PHRFCSVDAQ | 
    2200:
    SFLDKPGRPD | AQRWSSVELD | NGDGHLESGE | VRARASELEP | ALGARRKKKM | 
    2250:
    SPPCISIDPP | TEDEGSSRPP | AAEGGNTTLR | RRTPSCEAAL | HRDCPESTEG | 
    2300:
    PGTGGDPVAK | GERWGQASCR | AEHLTVPNFA | FEPLDMGGPG | GDCFLDSDQS | 
    2350:
    VTPEPRVSSL | GAIVPLILET | ELSMPSGDPP | EKEQGLYLTV | PQTPLKKPGS | 
    2365:
    PPATPAPDDS | GDEPV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    ELISA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    ELISA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    CLIA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    CLIA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    CLIA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    Polyclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    Polyclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    Polyclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    Monoclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    Monoclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    Monoclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    Protein for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    Protein for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
    Protein for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Exon organization of mouse Cacna1h."
      Mittman S.
      Submitted (2001-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: BALB/c.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    4. 4.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Aizawa H. , Yuasa S. , Nakajima D. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 900-2365 (ISOFORM 2)
      tissue: Brain.
    5. 5.
      "Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family."
      Cribbs L.L. , Lee J.-H. , Yang J. , Satin J. , Zhang Y. , Daud A.N. , Barclay J. , Wiliamson M.P. , Fox M. , Rees M. , Perez-Reyes E.
      Circ. Res.83:103-109(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1823-2365
      strain: C57BL/6J.
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