Gene name:
Cacna1h (Kiaa1120) ;
Protein name:
Voltage-dependent T-type calcium channel subunit alpha-1H ;
Alternative:
Voltage-gated calcium channel subunit alpha Cav3.2 ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MTEGTLAADE | VRVPLGASPS | APAAPVRASP | ASPGVPGREE | QRGSGSSVLA |
100:
PESPGTECGA | DLGADEEQPV | PYPALAATVF | FCLGQTTRPR | SWCLRLVSRR |
150:
WFEHISMLVI | MLNCVTLGMF | RPCEDVECRS | ERCSILEAFD | DFIFAFFAVE |
200:
MVIKMVALGL | FGQKCYLGDT | WNRLDFFIVM | AGMMEYSLDG | HNVSLSAIRT |
250:
VRVLRPLRAI | NRVPSMRILV | TLLLDTLPML | GNVLLLCFFV | FFIFGIVGVQ |
300:
LWAGLLRNRC | FLDSAFVRNN | NLTFLRPYYQ | TEEGEENPFI | CSSRRDNGMQ |
350:
KCSHIPSRRE | LRVQCTLGWE | AYGQPQAEDG | GAGRNACINW | NQYYNVCRSG |
400:
EFNPHNGAIN | FDNIGYAWIA | IFQVITLEGW | VDIMYYVMDA | HSFYNFIYFI |
450:
LLIIVGSFFM | INLCLVVIAT | QFSETKQREN | QLMREQRARY | LSNDSTLASF |
500:
SEPGSCYEEL | LKYVGHIFRK | VKRRSLRLYA | RWQSRWRKKV | DPSSTLHGQG |
550:
PRRRPRRAGR | RTASVHHLVY | HHHHHHHHHY | HFSHGGPRRP | SPEPGAGDTR |
600:
LVRACVPPSP | PSPGHGPPDS | ESVHSIYHAD | CHVEGPQERA | RVAHTIATAA |
650:
SLKLASGLGT | MNYPTILPSG | AVNSKGSTSS | RPKGLRSAGT | PGATAHSPLS |
700:
LGSPSPYEKI | QHVVGEQGLG | RASSHLSGLS | VPCPLPSPQA | GTLTCELKSC |
750:
PYCASALEDP | EFEFSGSESG | DSDAHGVYEF | TQDVRHGDCR | DPVQQPHEGG |
800:
TPGHGNERWR | PPLRTASQPG | GLGRLWASFS | SKLRRIVDSK | YFNRGIMAAI |
850:
LVNTLSMGVE | YHEQPDELTN | ALEISNIVFT | SMFALEMLLK | LLACGPLGYI |
900:
RNPYNIFDGI | VVIISVWEIV | GQADGGLSVL | RTFRLLRVLK | LVRFLPALRR |
950:
QLVVLMRTMD | NVATFCMLLM | LFIFIFSILG | MHLFGCKFSL | KTDSGDTVPD |
1000:
RKNFDSLLWA | IVTVFQILTQ | EDWNVVLYNG | MASTSSWAAL | YFVALMTFGN |
1050:
YVLFNLLVAI | LVEGFQAEGD | ATRSDTDEDK | TSTHLEEDFD | KLRDVQATEM |
1100:
KMYSLAVTPN | GHLEGRGSLP | PPLITHTAAT | PMPTPKSSPH | LDMAHTLLDS |
1150:
RRSSSGSVDP | QLGDQKSLAS | LRSSPCAPWG | PNSAGSSRRS | SWNSLGRAPS |
1200:
LKRRSQCGER | ESLLSGEGKG | STDDEAEDSR | PNSGTHPGAS | PGPRATPLRR |
1250:
AESLGHRSTM | DLCPPRPATL | LPTKFRDCNG | QMVALPSEFF | LRIDSHKEDA |
1300:
AEFDDDIEDS | CCFRLHKVLE | PYAPQWCSSR | ESWALYLFPP | QNRLRVSCQK |
1350:
VIAHKMFDHV | VLVFIFLNCI | TIALERPDID | PGSTERAFLS | VSNYIFTAIF |
1400:
VVEMMVKVVA | LGLLWGEHAY | LQSSWNVLDG | LLVLVSLVDI | IVAVASAGGA |
1450:
KILGVLRVLR | LLRTLRPLRV | ISRAPGLKLV | VETLISSLRP | IGNIVLICCA |
1500:
FFIIFGILGV | QLFKGKFYYC | EGTDTRNITT | KAECHAAHYR | WVRRKYNFDN |
1550:
LGQALMSLFV | LSSKDGWVNI | MYDGLDAVGI | DQQPVQNHNP | WMLLYFISFL |
1600:
LIVSFFVLNM | FVGVVVENFH | KCRQHQEAEE | ARRREEKRLR | RLERRRRSTF |
1650:
PNPEAQRRPY | YADYSHTRRS | IHSLCTSHYL | DLFITFIICL | NVITMSMEHY |
1700:
NQPKSLDEAL | KYCNYVFTIV | FVFEAALKLV | AFGFRRFFKD | RWNQLDLAIV |
1750:
LLSIMGIALE | EIEMNAALPI | NPTIIRIMRV | LRIARVLKLL | KMATGMRALL |
1800:
DTVVQALPQV | GNLGLLFMLL | FFIYAALGVE | LFGRLECSED | NPCEGLSRHA |
1850:
TFTNFGMAFL | TLFRVSTGDN | WNGIMKDTLR | ECTREDKHCL | SYLPALSPVY |
1900:
FVTFVLVAQF | VLVNVVVAVL | MKHLEESNKE | AREDAEMDAE | IELEIAQGST |
1950:
AQPPSTAQES | QGTEPDTPNL | LVVRKVSVSR | MLSLPNDSYM | FRPVAPAAAP |
2000:
HSHPLQEVEM | ETYTGPVTSA | HSPSLEPRTS | FQVPSAASSP | ARVSDPLCAL |
2050:
SPRDTPRSLS | LSRILCRQEA | MHAESLEGQI | DDAGEDSIPD | YTEPAENISM |
2100:
SQAPLGTLRS | PPCSPRPASV | RTRKHTFGQH | CISSRPPTLG | GDDAEAADPA |
2150:
DEEVSHITSS | AHPWPATEPH | SPEASPTASP | AKGTVGSGRD | PHRFCSVDAQ |
2200:
SFLDKPGRPD | AQRWSSVELD | NGDGHLESGE | VRARASELEP | ALGARRKKKM |
2250:
SPPCISIDPP | TEDEGSSRPP | AAEGGNTTLR | RRTPSCEAAL | HRDCPESTEG |
2300:
PGTGGDPVAK | GERWGQASCR | AEHLTVPNFA | FEPLDMGGPG | GDCFLDSDQS |
2350:
VTPEPRVSSL | GAIVPLILET | ELSMPSGDPP | EKEQGLYLTV | PQTPLKKPGS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
ELISA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
ELISA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
CLIA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
CLIA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
CLIA Kit for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
Polyclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
Polyclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
Polyclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
Monoclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
Monoclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
Monoclonal Antibody for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
Protein for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
Protein for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
Protein for Mouse Voltage-dependent T-type calcium channel subunit alpha-1H
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Exon organization of mouse Cacna1h."
Mittman S.
Submitted (2001-02) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
BALB/c .
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 900-2365 (ISOFORM 2)
tissue :
Brain .
5.
"Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family."
Cribbs L.L.
,
Lee J.-H.
,
Yang J.
,
Satin J.
,
Zhang Y.
,
Daud A.N.
,
Barclay J.
,
Wiliamson M.P.
,
Fox M.
,
Rees M.
,
Perez-Reyes E.
Circ. Res.83:103-109(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1823-2365
strain :
C57BL/6J .