CACNA1S ELISA Kit for Rabbit(Oryctolagus cuniculus) | EIAab.comCACNA1S ELISA Kit for Rabbit(Oryctolagus cuniculus)

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CACNA1S (Gene name),

Voltage-dependent L-type calcium channel subunit alpha-1S (Protein name ), CAC1S_RABIT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CACNA1S(CACH1;CACNL1A3);

Protein name:

Voltage-dependent L-type calcium channel subunit alpha-1S;

Alternative:

Voltage-gated calcium channel subunit alpha Cav1.1;Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle;

Organism:

Rabbit (Oryctolagus cuniculus).

General Annotation

Sub Unit:

Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. An additional gamma subunit is present only in skeletal muscle L-type channel. Interacts with DYSF and JSRP1.

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

1873

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1873:

RRSSLGSLDQ | VQGSQETLIP | PRP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08763

UniGene:

Ocu.1826

SMR:

P07293

STRING:

9986.ENSOCUP00000003147

Uniprot:

P07293

FOR

ELISA Kit for Rabbit Voltage-dependent L-type calcium channel subunit alpha-1S

CLIA Kit for Rabbit Voltage-dependent L-type calcium channel subunit alpha-1S

Polyclonal Antibody for Rabbit Voltage-dependent L-type calcium channel subunit alpha-1S

Monoclonal Antibody for Rabbit Voltage-dependent L-type calcium channel subunit alpha-1S

Protein for Rabbit Voltage-dependent L-type calcium channel subunit alpha-1S

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Primary structure of the receptor for calcium channel blockers from skeletal muscle."
Tanabe T. , Takeshima H. , Mikami A. , Flockerzi V. , Takahashi H. , Kangawa K. , Kojima M. , Matsuo H. , Hirose T. , Numa S.
Nature328:313-318(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue: Skeletal muscle.
2.

"Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel."
Ellis S.B. , Williams M.E. , Ways N.R. , Brenner R. , Sharp A.H. , Leung A.T. , Campbell K.P. , McKenna E. , Koch W.J. , Hui A. , Schwartz A. , Harpold M.M.
Science241:1661-1664(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Skeletal muscle.
3.

"Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit."
Pragnell M. , de Waard M. , Mori Y. , Tanabe T. , Snutch T.P. , Campbell K.P.
Nature368:67-70(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BETA-SUBUNIT BINDING DOMAIN
4.

"Identification of a phenylalkylamine binding region within the alpha 1 subunit of skeletal muscle Ca2+ channels."
Striessnig J. , Glossmann H. , Catterall W.A.
Proc. Natl. Acad. Sci. U.S.A.87:9108-9112(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHENYLALKYLAMINE-BINDING SITE
5.

"Identification of 1,4-dihydropyridine binding regions within the alpha 1 subunit of skeletal muscle Ca2+ channels by photoaffinity labeling with diazipine."
Nakayama H. , Taki M. , Striessnig J. , Glossmann H. , Catterall W.A. , Kanaoka Y.
Proc. Natl. Acad. Sci. U.S.A.88:9203-9207(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DIHYDROPYRIDINE-BINDING SITE
6.

"Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit."
Striessnig J. , Murphy B.J. , Catterall W.A.
Proc. Natl. Acad. Sci. U.S.A.88:10769-10773(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DIHYDROPYRIDINE-BINDING SITE
7.

"CAMP-dependent protein kinase rapidly phosphorylates serine-687 of the skeletal muscle receptor for calcium channel blockers."
Roehrkasten A. , Meyer H.E. , Nastainczyk W. , Sieber M. , Hofmann F.
J. Biol. Chem.263:15325-15329(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-687 AND SER-1617
8.

"Activation of purified calcium channels by stoichiometric protein phosphorylation."
Nunoki K. , Florio V. , Catterall W.A.
Proc. Natl. Acad. Sci. U.S.A.86:6816-6820(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY PKA
9.

"Activation and inhibition of skeletal RyR channels by a part of the skeletal DHPR II-III loop: effects of DHPR Ser687 and FKBP12."
Dulhunty A.F. , Laver D.R. , Gallant E.M. , Casarotto M.G. , Pace S.M. , Curtis S.
Biophys. J.77:189-203(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RYR1
10.

"A structural requirement for activation of skeletal ryanodine receptors by peptides of the dihydropyridine receptor II-III loop."
Casarotto M.G. , Gibson F. , Pace S.M. , Curtis S.M. , Mulcair M. , Dulhunty A.F.
J. Biol. Chem.275:11631-11637(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 671-690
11.

"Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha1 interaction domain."
Opatowsky Y. , Chen C.-C. , Campbell K.P. , Hirsch J.A.
Neuron42:387-399(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 34-415 IN COMPLEX WITH CACNB2

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