Cacna1s ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCacna1s ELISA Kit for Rat(Rattus norvegicus)

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Cacna1s (Gene name),

Voltage-dependent L-type calcium channel subunit alpha-1S (Protein name ), CAC1S_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cacna1s(Cach1;Cacn1;Cacnl1a3;Cchl1a3);

Protein name:

Voltage-dependent L-type calcium channel subunit alpha-1S;

Alternative:

ROB1;Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle;Voltage-gated calcium channel subunit alpha Cav1.1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. An additional gamma subunit is present only in skeletal muscle L-type channel. Interacts with DYSF and JSRP1.

Function:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

1146

Sequence:

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1050:

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1146:

GQALADACQM | EPEEVEVAAT | ELLKRESPKG | GPCPGSLEPK | VLPWAA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08763

UniGene:

Rn.10738

SMR:

Q02485

Uniprot:

Q02485

FOR

ELISA Kit for Rat Voltage-dependent L-type calcium channel subunit alpha-1S

CLIA Kit for Rat Voltage-dependent L-type calcium channel subunit alpha-1S

Polyclonal Antibody for Rat Voltage-dependent L-type calcium channel subunit alpha-1S

Monoclonal Antibody for Rat Voltage-dependent L-type calcium channel subunit alpha-1S

Protein for Rat Voltage-dependent L-type calcium channel subunit alpha-1S

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The gene for the alpha-1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse chromosome 1."
Chin H. , Krall M. , Kim H.-L. , Kozak C.A. , Mock B.A.
Genomics14:1089-1091(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney."
Yu A.S.L. , Hebert S.C. , Brenner B.M. , Lytton J.
Proc. Natl. Acad. Sci. U.S.A.89:10494-10498(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 597-691
tissue: Kidney.
3.

"Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone."
Barry E.L.R. , Gesek F.A. , Froehner S.C. , Friedman P.A.
Proc. Natl. Acad. Sci. U.S.A.92:10914-10918(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 359-658 (ISOFORM ROB1)
tissue: Osteosarcoma.
4.

"Cyclic AMP-dependent phosphorylation of two size forms of alpha 1 subunits of L-type calcium channels in rat skeletal muscle cells."
Lai Y. , Seagar M.J. , Takahashi M. , Catterall W.A.
J. Biol. Chem.265:20839-20848(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY PKA

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