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Index > Protein center > CALCOCO2(Gene name) > Human
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  • CALCOCO2 (Gene name),
  • Calcium-binding and coiled-coil domain-containing protein 2 (Protein name ),  CACO2_HUMAN from NCBI database.
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  • Gene name:
    CALCOCO2(NDP52);
    Protein name:
    Calcium-binding and coiled-coil domain-containing protein 2;
    Alternative:
    Nuclear domain 10 protein NDP52(Nuclear domain 10 protein 52);Antigen nuclear dot 52 kDa protein;Nuclear dot protein 52;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with GEMIN4.
    Function:
    May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion.
    Subcellular Location:
    Cytoplasm perinuclear region Golgi apparatus Cytoplasm cytoskeleton According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus.
    Protein Attributes:
    Sequence length:
    446
    Sequence:
    50:
    MEETIKDPPT | SAVLLDHCHF | SQVIFNSVEK | FYIPGGDVTC | HYTFTQHFIP | 
    100:
    RRKDWIGIFR | VGWKTTREYY | TFMWVTLPID | LNNKSAKQQE | VQFKAYYLPK | 
    150:
    DDEYYQFCYV | DEDGVVRGAS | IPFQFRPENE | EDILVVTTQG | EVEEIEQHNK | 
    200:
    ELCKENQELK | DSCISLQKQN | SDMQAELQKK | QEELETLQSI | NKKLELKVKE | 
    250:
    QKDYWETELL | QLKEQNQKMS | SENEKMGIRV | DQLQAQLSTQ | EKEMEKLVQG | 
    300:
    DQDKTEQLEQ | LKKENDHLFL | SLTEQRKDQK | KLEQTVEQMK | QNETTAMKKQ | 
    350:
    QELMDENFDL | SKRLSENEII | CNALQRQKER | LEGENDLLKR | ENSRLLSYMG | 
    400:
    LDFNSLPYQV | PTSDEGGARQ | NPGLAYGNPY | SGIQESSSPS | PLSIKKCPIC | 
    446:
    KADDICDHTL | EQQQMQPLCF | NCPICDKIFP | ATEKQIFEDH | VFCHSL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    KEGG:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Calcium-binding and coiled-coil domain-containing protein 2
    ELISA Kit for Human Calcium-binding and coiled-coil domain-containing protein 2
    ELISA Kit for Human Calcium-binding and coiled-coil domain-containing protein 2
    CLIA Kit for Human Calcium-binding and coiled-coil domain-containing protein 2
    CLIA Kit for Human Calcium-binding and coiled-coil domain-containing protein 2
    CLIA Kit for Human Calcium-binding and coiled-coil domain-containing protein 2
    Polyclonal Antibody for Human Calcium-binding and coiled-coil domain-containing protein 2
    Polyclonal Antibody for Human Calcium-binding and coiled-coil domain-containing protein 2
    Polyclonal Antibody for Human Calcium-binding and coiled-coil domain-containing protein 2
    Monoclonal Antibody for Human Calcium-binding and coiled-coil domain-containing protein 2
    Monoclonal Antibody for Human Calcium-binding and coiled-coil domain-containing protein 2
    Monoclonal Antibody for Human Calcium-binding and coiled-coil domain-containing protein 2
    Protein for Human Calcium-binding and coiled-coil domain-containing protein 2
    Protein for Human Calcium-binding and coiled-coil domain-containing protein 2
    Protein for Human Calcium-binding and coiled-coil domain-containing protein 2

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    Precision
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    Linearity
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    References
    1. 1.
      "Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment."
      Korioth F. , Gieffers C. , Maul G.G. , Frey J.
      J. Cell Biol.130:1-13(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5);VARIANTS GLU-140; ALA-248 AND ALA-389
      tissue: Mammary gland.
      tissue: Neuroblastoma.
      tissue: Teratocarcinoma.
      tissue: Thymus.
    3. 3.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-248
    4. 4.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-389
      tissue: Brain.
      tissue: Gastric mucosa.
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-389
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-273
      tissue: Kidney.
      tissue: Skin.
    7. 8.
      "Cellular localization, expression, and structure of the nuclear dot protein 52."
      Sternsdorf T. , Jensen K. , Zuchner D. , Will H.
      J. Cell Biol.138:435-448(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    8. 9.
      "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins."
      Di Y. , Li J. , Zhang Y. , He X. , Lu H. , Xu D. , Ling J. , Huo K. , Wan D. , Li Y.Y. , Gu J.
      J. Biochem.133:713-718(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GEMIN4;SUBCELLULAR LOCATION
    9. 10.
      "T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion."
      Morriswood B. , Ryzhakov G. , Puri C. , Arden S.D. , Roberts R. , Dendrou C. , Kendrick-Jones J. , Buss F.
      J. Cell Sci.120:2574-2585(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TAX1BP1 AND MYO6;MUTAGENESIS OF CYS-400 AND CYS-425
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