CADM1 ELISA Kit for Human(Homo sapiens) | EIAab.comCADM1 ELISA Kit for Human(Homo sapiens) | EIAab.com

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CADM1 (Gene name),

Cell adhesion molecule 1 (Protein name ), CADM1_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

CADM1(IGSF4;IGSF4A;NECL2;SYNCAM;TSLC1);

Protein name:

Cell adhesion molecule 1;

Alternative:

Nectin-like protein 2(NECL-2);Immunoglobulin superfamily member 4(IgSF4);Synaptic cell adhesion molecule(SynCAM);Spermatogenic immunoglobulin superfamily(SgIgSF);Tumor suppressor in lung cancer 1(TSLC-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with CRTAM and EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6.

Function:

Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.

Protein Attributes:

Sequence length:

442

Sequence:

50:

MASVVLPSGS | QCAAAAAAAA | PPGLRLRLLL | LLFSAAALIP | TGDGQNLFTK |

100:

DVTVIEGEVA | TISCQVNKSD | DSVIQLLNPN | RQTIYFRDFR | PLKDSRFQLL |

150:

NFSSSELKVS | LTNVSISDEG | RYFCQLYTDP | PQESYTTITV | LVPPRNLMID |

200:

IQKDTAVEGE | EIEVNCTAMA | SKPATTIRWF | KGNTELKGKS | EVEEWSDMYT |

250:

VTSQLMLKVH | KEDDGVPVIC | QVEHPAVTGN | LQTQRYLEVQ | YKPQVHIQMT |

300:

YPLQGLTREG | DALELTCEAI | GKPQPVMVTW | VRVDDEMPQH | AVLSGPNLFI |

350:

NNLNKTDNGT | YRCEASNIVG | KAHSDYMLYV | YDPPTTIPPP | TTTTTTTTTT |

400:

TTTILTIITD | SRAGEEGSIR | AVDHAVIGGV | VAVVVFAMLC | LLIILGRYFA |

442:

RHKGTYFTHE | AKGADDAADA | DTAIINAEGG | QNNSEEKKEY | FI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000329797

Pfam:

String:

SMR:

KEGG:

UniGene:

MIM:

Uniprot:

FOR

ELISA Kit for Human Cell adhesion molecule 1

ELISA Kit for Human Cell adhesion molecule 1

CLIA Kit for Human Cell adhesion molecule 1

CLIA Kit for Human Cell adhesion molecule 1

Polyclonal Antibody for Human Cell adhesion molecule 1

Polyclonal Antibody for Human Cell adhesion molecule 1

Monoclonal Antibody for Human Cell adhesion molecule 1

Monoclonal Antibody for Human Cell adhesion molecule 1

Protein for Human Cell adhesion molecule 1

Protein for Human Cell adhesion molecule 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane."
Zhou Y. , Du G. , Hu X. , Yu S. , Liu Y. , Xu Y. , Huang X. , Liu J. , Yin B. , Fan M. , Peng X. , Qiang B. , Yuan J.
Biochim. Biophys. Acta1669:142-154(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion."
Moiseeva E.P. , Leyland M.L. , Bradding P.
Cell. Mol. Life Sci.69:2751-2764(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4);FUNCTION;SUBCELLULAR LOCATION;ALTERNATIVE SPLICING
tissue: Mast cell.
3.

"Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
Corominas R. , Yang X. , Lin G.N. , Kang S. , Shen Y. , Ghamsari L. , Broly M. , Rodriguez M. , Tam S. , Wanamaker S.A. , Fan C. , Yi S. , Tasan M. , Lemmens I. , Kuang X. , Zhao N. , Malhotra D. , Michaelson J.J. , more...
Nat. Commun.5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
tissue: Fetal brain.
4.

"Cloning of a secretory isoform of SgIGSF/TSLC-1."
Ito A. , Koma Y. , Nagano T.
Submitted (2002-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Lung.
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Embryo.
6.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
8.

"TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer."
Kuramochi M. , Fukuhara H. , Nobukuni T. , Kanbe T. , Maruyama T. , Ghosh H.P. , Pletcher M. , Isomura M. , Onizuka M. , Kitamura T. , Sekiya T. , Reeves R.H. , Murakami Y.
Nat. Genet.27:427-430(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
9.

"Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer."
Yageta M. , Kuramochi M. , Masuda M. , Fukami T. , Fukuhara H. , Maruyama T. , Shibuya M. , Murakami Y.
Cancer Res.62:5129-5133(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EPB41L3
10.

"The tumor suppressor protein TSLC1 is involved in cell-cell adhesion."
Masuda M. , Yageta M. , Fukuhara H. , Kuramochi M. , Maruyama T. , Nomoto A. , Murakami Y.
J. Biol. Chem.277:31014-31019(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;GLYCOSYLATION
11.

"The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer."
Mao X. , Seidlitz E. , Ghosh K. , Murakami Y. , Ghosh H.P.
Cancer Res.63:7979-7985(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN
12.

"Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines."
Fukami T. , Fukuhara H. , Kuramochi M. , Maruyama T. , Isogai K. , Sakamoto M. , Takamoto S. , Murakami Y.
Int. J. Cancer107:53-59(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
13.

"Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma."
Ito A. , Okada M. , Uchino K. , Wakayama T. , Koma Y. , Iseki S. , Tsubota N. , Okita Y. , Kitamura Y.
Lab. Invest.83:1175-1183(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg."
Fukuhara H. , Masuda M. , Yageta M. , Fukami T. , Kuramochi M. , Maruyama T. , Kitamura T. , Murakami Y.
Oncogene22:6160-6165(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MPP3
15.

"Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth."
Mao X. , Seidlitz E. , Truant R. , Hitt M. , Ghosh H.P.
Oncogene23:5632-5642(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN
16.

"The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM."
Boles K.S. , Barchet W. , Diacovo T. , Cella M. , Colonna M.
Blood106:779-786(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CRTAM
17.

"Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule."
Galibert L. , Diemer G.S. , Liu Z. , Johnson R.S. , Smith J.L. , Walzer T. , Comeau M.R. , Rauch C.T. , Wolfson M.F. , Sorensen R.A. , Van der Vuurst de Vries A.-R. , Branstetter D.G. , Koelling R.M. , Scholler J. , Fanslow W.C. , Baum P.R. , Derry J.M. , Yan W.
J. Biol. Chem.280:21955-21964(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRTAM
18.

"The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves."
Furuno T. , Ito A. , Koma Y. , Watabe K. , Yokozaki H. , Bienenstock J. , Nakanishi M. , Kitamura Y.
J. Immunol.174:6934-6942(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-101 AND ASN-113
tissue: Plasma.
20.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-101 AND ASN-113
tissue: Liver.
21.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-101; ASN-113; ASN-301 AND ASN-302
tissue: Leukemic T-cell.
22.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B)."
Busam R.D. , Thorsell A.G. , Flores A. , Hammarstrom M. , Persson C. , Obrink B. , Hallberg B.M.
J. Biol. Chem.286:4511-4516(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 400-411 IN COMPLEX WITH EPB41L3;MUTAGENESIS OF TYR-406 AND THR-408;INTERACTION WITH EPB41L3

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