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Index > Protein center > CALD1(Gene name) > Chicken
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  • CALD1 (Gene name),
  • Caldesmon (Protein name ),  CALD1_CHICK from NCBI database.
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  • Gene name:
    CALD1(CAD);
    Protein name:
    Caldesmon(CDM);
    Alternative:

    Organism:
    Chicken (Gallus gallus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping.
    Subcellular Location:
    Cytoplasm cytoskeleton Cytoplasm myofibril On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).
    Protein Attributes:
    Sequence length:
    771
    Sequence:
    50:
    MDDFERRREL | RRQKREEMRL | EAERLSYQRN | DDDEEEAARE | RRRRARQERL | 
    100:
    RQKEEGDVSG | EVTEKSEVNA | QNSVAEEETK | RSTDDEAALL | ERLARREERR | 
    150:
    QKRLQEALER | QKEFDPTITD | GSLSVPSRRE | VNNVEENEIT | GKEEKVETRQ | 
    200:
    GRCEIEETET | VTKSYQRNNW | RQDGEEEGKK | EEKDSEEEKP | KEVPTEENQV | 
    250:
    DVAVEKSTDK | EEVVETKTLA | VNAENDTNAM | LEGEQSITDA | ADKEKEEAEK | 
    300:
    EREKLEAEEK | ERLKAEEEKK | AAEEKQKAEE | EKKAAEERER | AKAEEEKRAA | 
    350:
    EERERAKAEE | ERKAAEERER | AKAEEERKAA | EERAKAEEER | KAAEERAKAE | 
    400:
    EERKAAEERA | KAEKERKAAE | ERERAKAEEE | KRAAEEKARL | EAEKLKEKKK | 
    450:
    MEEKKAQEEK | AQANLLRKQE | EDKEAKVEAK | KESLPEKLQP | TSKKDQVKDN | 
    500:
    KDKEKAPKEE | MKSVWDRKRG | VPEQKAQNGE | RELTTPKLKS | TENAFGRSNL | 
    550:
    KGAANAEAGS | EKLKEKQQEA | AVELDELKKR | REERRKILEE | EEQKKKQEEA | 
    600:
    ERKIREEEEK | KRMKEEIERR | RAEAAEKRQK | VPEDGVSEEK | KPFKCFSPKG | 
    650:
    SSLKIEERAE | FLNKSAQKSG | MKPAHTTAVV | SKIDSRLEQY | TSAVVGNKAA | 
    700:
    KPAKPAASDL | PVPAEGVRNI | KSMWEKGNVF | SSPGGTGTPN | KETAGLKVGV | 
    750:
    SSRINEWLTK | TPEGNKSPAP | KPSDLRPGDV | SGKRNLWEKQ | SVEKPAASSS | 
    771:
    KVTATGKKSE | TNGLRQFEKE | P
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Chicken CDM
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    ELISA Kit for Chicken CDM
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    CLIA Kit for Chicken CDM
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    Packing:
    96T
    CLIA Kit for Chicken CDM
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    Please sign in first.
    CLIA Kit for Chicken CDM
    Cat.:
    U1324h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Chicken CDM
    Cat.:
    U1324r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Chicken CDM
    Cat.:
    P1324Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Chicken CDM
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    P1324Rb-h
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    Packing:
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    Polyclonal Antibody for Chicken CDM
    Polyclonal Antibody for Chicken CDM
    Monoclonal Antibody for Chicken CDM
    Monoclonal Antibody for Chicken CDM
    Monoclonal Antibody for Chicken CDM
    Monoclonal Antibody for Chicken CDM
    Protein for Chicken CDM
    Protein for Chicken CDM
    Protein for Chicken CDM
    Protein for Chicken CDM

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    Linearity
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    References
    1. 1.
      "Cloning and expression of a smooth muscle caldesmon."
      Bryan J. , Imai M. , Lee R. , Moore P. , Cook R.G. , Lin W.-G.
      J. Biol. Chem.264:13873-13879(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE (ISOFORM GIZZARD H-CAD)
      tissue: Gizzard.
      tissue: Oviduct.
    2. 2.
      "Primary structure and functional expression of h-caldesmon complementary DNA."
      Hayashi K. , Kanda K. , Kimizuka F. , Kato I. , Sobue K.
      Biochem. Biophys. Res. Commun.164:503-511(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE (ISOFORM GIZZARD H-CAD)
      tissue: Gizzard.
    3. 3.
      "Structural and functional relationships between h- and l-caldesmons."
      Hayashi K. , Fujio Y. , Kato I. , Sobue K.
      J. Biol. Chem.266:355-361(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE (ISOFORM BRAIN L-CAD)
      tissue: Brain.
    4. 4.
      "Common structural and expressional properties of vertebrate caldesmon genes."
      Haruna M. , Hayashi K. , Yano H. , Takeuchi O. , Sobue K.
      Biochem. Biophys. Res. Commun.197:145-153(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (GIZZARD H-CAD; BRAIN L-CAD AND GIZZARD L-CAD)
    5. 5.
      "Sequence of an avian non-muscle caldesmon."
      Bryan J. , Lee R.
      J. Muscle Res. Cell Motil.12:372-375(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM GIZZARD L-CAD)
      tissue: Gizzard.
    6. 6.
      "Identification of two distinct promoters in the chicken caldesmon gene."
      Yano H. , Hayashi K. , Haruna M. , Sobue K.
      Biochem. Biophys. Res. Commun.201:618-626(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15 (ISOFORM BRAIN L-CAD)
      tissue: Brain.
    7. 7.
      "35 kDa fragment of h-caldesmon conserves two consensus sequences of the tropomyosin-binding domain in troponin T."
      Hayashi K. , Yamada S. , Kanda K. , Kimizuka F. , Kato I. , Sobue K.
      Biochem. Biophys. Res. Commun.161:38-45(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 451-756;PARTIAL PROTEIN SEQUENCE
      tissue: Gizzard.
    8. 8.
      "Identification of a 15 kilodalton actin binding region on gizzard caldesmon probed by chemical cross-linking."
      Mornet D. , Audemard E. , Derancourt J.
      Biochem. Biophys. Res. Commun.154:564-571(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 498-525
    9. 9.
      "Phosphorylation of caldesmon by p34cdc2 kinase. Identification of phosphorylation sites."
      Mak A.S. , Carpenter M. , Smillie L.B. , Wang J.H.
      J. Biol. Chem.266:19971-19975(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-597; SER-682; THR-688; THR-711 AND SER-717
    10. 10.
      "Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex."
      Wang Z. , Danielsen A.J. , Maihle N.J. , McManus M.J.
      J. Biol. Chem.274:33807-33813(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-27 AND TYR-165
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