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Index > Protein center > Canx(Gene name) > Mouse
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  • Canx (Gene name),
  • Calnexin (Protein name ),  CALX_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Canx;
    Protein name:
    Calnexin;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Partial T-cell antigen receptor complexes can escape the ER of immature thymocytes in association with their molecular chaperone to be expressed at low levels on the cell surface where they may function as a signaling complex to regulate thymocyte maturation.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type I membrane protein Melanosome When bound to CD3 epsilon chains, calnexin's ER retention signal can be masked, permitting it to escape ER retention.
    Protein Attributes:
    Sequence length:
    591
    Sequence:
    50:
    MEGKWLLCLL | LVLGTAAVEA | HDGHDDDAID | IEDDLDDVIE | EVEDSKSKSD | 
    100:
    ASTPPSPKVT | YKAPVPTGEV | YFADSFDRGS | LSGWILSKAK | KDDTDDEIAK | 
    150:
    YDGKWEVDEM | KETKLPGDKG | LVLMSRAKHH | AISAKLNKPF | LFDTKPLIVQ | 
    200:
    YEVNFQNGIE | CGGAYVKLLS | KTAELSLDQF | HDKTPYTIMF | GPDKCGEDYK | 
    250:
    LHFIFRHKNP | KTGVYEEKHA | KRPDADLKTY | FTDKKTHLYT | LILNPDNSFE | 
    300:
    ILVDQSVVNS | GNLLNDMTPP | VNPSREIEDP | EDRKPEDWDE | RPKIADPDAV | 
    350:
    KPDDWDEDAP | SKIPDEEATK | PEGWLDDEPE | YIPDPDAEKP | EDWDEDMDGE | 
    400:
    WEAPQIANPK | CESAPGCGVW | QRPMIDNPNY | KGKWKPPMID | NPNYQGIWKP | 
    450:
    RKIPNPDFFE | DLEPFKMTPF | SAIGLELWSM | TSDIFFDNFI | ISGDRRVVDD | 
    500:
    WANDGWGLKK | AADGAAEPGV | VLQMLEAAEE | RPWLWVVYIL | TVALPVFLVI | 
    550:
    LFCCSGKKQS | NAMEYKKTDA | PQPDVKDEEG | KEEEKNKRDE | EEEEEKLEEK | 
    591:
    QKSDAEEDGV | TGSQDEEDSK | PKAEEDEILN | RSPRNRKPRR | E
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Calnexin
    Cat.:
    E0280h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Calnexin
    Cat.:
    E0280d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Calnexin
    Cat.:
    E0280m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Calnexin
    Cat.:
    E0280r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Calnexin
    Cat.:
    U0280m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Calnexin
    Cat.:
    U0280r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Calnexin
    Cat.:
    U0280d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Calnexin
    Cat.:
    U0280h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Calnexin
    Cat.:
    P0280Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Calnexin
    Polyclonal Antibody for Mouse Calnexin
    Cat.:
    P0280Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Calnexin
    Cat.:
    P0280Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Calnexin
    Monoclonal Antibody for Mouse Calnexin
    Monoclonal Antibody for Mouse Calnexin
    Monoclonal Antibody for Mouse Calnexin
    Protein for Mouse Calnexin
    Protein for Mouse Calnexin
    Protein for Mouse Calnexin
    Protein for Mouse Calnexin

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    Linearity
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    References
    1. 1.
      "Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5."
      Tjoelker L.W. , Seyfried C.E. , Eddy R.L. Jr. , Shows T.B. Jr. , Calderon J. , Schreiber R.B. , Gray P.W.
      Biochemistry33:3229-3236(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary gland.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-155
      strain: C57BL/6J.
      tissue: Eye.
    4. 4.
      "Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum."
      Schreiber K.L. , Bell M.P. , Huntoon C.J. , Rajagopalan S. , Brenner M.B. , McKean D.J.
      Int. Immunol.6:101-111(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-591
      strain: BALB/c.
    5. 5.
      "The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes."
      Wiest D.L. , Burgess W.H. , McKean D. , Kearse K.P. , Singer A.
      EMBO J.14:3425-3433(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THYMOCYTE MATURATION;SUBCELLULAR LOCATION
    6. 6.
      "A differential phosphoproteomic analysis of retinoic acid-treated P19 cells."
      Smith J.C. , Duchesne M.A. , Tozzi P. , Ethier M. , Figeys D.
      J. Proteome Res.6:3174-3186(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Teratocarcinoma.
    7. 7.
      "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P. , Tweedie-Cullen R. , Livingstone-Zatchej M. , Weinandy F. , Waidelich M. , Longo D. , Gehrig P. , Potthast F. , Rutishauser D. , Gerrits B. , Panse C. , Schlapbach R. , Mansuy I.M.
      Mol. Cell. Proteomics6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain cortex.
    8. 8.
      "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H. , Ye M. , Dong J. , Han G. , Jiang X. , Wu R. , Zou H.
      J. Proteome Res.7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    9. 9.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553; SER-563 AND SER-582;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-582;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    11. 11.
      "Enhanced clathrin-dependent endocytosis in the absence of calnexin."
      Li H.D. , Liu W.X. , Michalak M.
      PLoS ONE6:E21678-E21678(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SGIP1
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