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Index > Protein center > CAND1(Gene name) > Human
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  • CAND1 (Gene name),
  • Cullin-associated NEDD8-dissociated protein 1 (Protein name ),  CAND1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CAND1(KIAA0829;TIP120;TIP120A);
    Protein name:
    Cullin-associated NEDD8-dissociated protein 1;
    Alternative:
    TBP-interacting protein of 120 kDa A(TBP-interacting protein 120A);Cullin-associated and neddylation-dissociated protein 1;p120 CAND1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Binds unneddylated CUL1, but cannot bind CUL1 once it has been neddylated. Binds CUL2, CUL3, CUL4A, CUL4B and CUL5.
    Function:
    Enhances transcription from various types of promoters (By similarity). Regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. Prevents neddylation of CUL1 by physically blocking access to the neddylation site. Disrupts interactions between CUL1 and SKP1 and between CUL1 and F-box proteins.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1230
    Sequence:
    50:
    MASASYHISN | LLEKMTSSDK | DFRFMATNDL | MTELQKDSIK | LDDDSERKVV | 
    100:
    KMILKLLEDK | NGEVQNLAVK | CLGPLVSKVK | EYQVETIVDT | LCTNMLSDKE | 
    150:
    QLRDISSIGL | KTVIGELPPA | SSGSALAANV | CKKITGRLTS | AIAKQEDVSV | 
    200:
    QLEALDIMAD | MLSRQGGLLV | NFHPSILTCL | LPQLTSPRLA | VRKRTIIALG | 
    250:
    HLVMSCGNIV | FVDLIEHLLS | ELSKNDSMST | TRTYIQCIAA | ISRQAGHRIG | 
    300:
    EYLEKIIPLV | VKFCNVDDDE | LREYCIQAFE | SFVRRCPKEV | YPHVSTIINI | 
    350:
    CLKYLTYDPN | YNYDDEDEDE | NAMDADGGDD | DDQGSDDEYS | DDDDMSWKVR | 
    400:
    RAAAKCLDAV | VSTRHEMLPE | FYKTVSPALI | SRFKEREENV | KADVFHAYLS | 
    450:
    LLKQTRPVQS | WLCDPDAMEQ | GETPLTMLQS | QVPNIVKALH | KQMKEKSVKT | 
    500:
    RQCCFNMLTE | LVNVLPGALT | QHIPVLVPGI | IFSLNDKSSS | SNLKIDALSC | 
    550:
    LYVILCNHSP | QVFHPHVQAL | VPPVVACVGD | PFYKITSEAL | LVTQQLVKVI | 
    600:
    RPLDQPSSFD | ATPYIKDLFT | CTIKRLKAAD | IDQEVKERAI | SCMGQIICNL | 
    650:
    GDNLGSDLPN | TLQIFLERLK | NEITRLTTVK | ALTLIAGSPL | KIDLRPVLGE | 
    700:
    GVPILASFLR | KNQRALKLGT | LSALDILIKN | YSDSLTAAMI | DAVLDELPPL | 
    750:
    ISESDMHVSQ | MAISFLTTLA | KVYPSSLSKI | SGSILNELIG | LVRSPLLQGG | 
    800:
    ALSAMLDFFQ | ALVVTGTNNL | GYMDLLRMLT | GPVYSQSTAL | THKQSYYSIA | 
    850:
    KCVAALTRAC | PKEGPAVVGQ | FIQDVKNSRS | TDSIRLLALL | SLGEVGHHID | 
    900:
    LSGQLELKSV | ILEAFSSPSE | EVKSAASYAL | GSISVGNLPE | YLPFVLQEIT | 
    950:
    SQPKRQYLLL | HSLKEIISSA | SVVGLKPYVE | NIWALLLKHC | ECAEEGTRNV | 
    1000:
    VAECLGKLTL | IDPETLLPRL | KGYLISGSSY | ARSSVVTAVK | FTISDHPQPI | 
    1050:
    DPLLKNCIGD | FLKTLEDPDL | NVRRVALVTF | NSAAHNKPSL | IRDLLDTVLP | 
    1100:
    HLYNETKVRK | ELIREVEMGP | FKHTVDDGLD | IRKAAFECMY | TLLDSCLDRL | 
    1150:
    DIFEFLNHVE | DGLKDHYDIK | MLTFLMLVRL | STLCPSAVLQ | RLDRLVEPLR | 
    1200:
    ATCTTKVKAN | SVKQEFEKQD | ELKRSAMRAV | AALLTIPEAE | KSPLMSEFQS | 
    1230:
    QISSNPELAA | IFESIQKDSS | STNLESMDTS | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cullin-associated NEDD8-dissociated protein 1
    ELISA Kit for Human Cullin-associated NEDD8-dissociated protein 1
    ELISA Kit for Human Cullin-associated NEDD8-dissociated protein 1
    ELISA Kit for Human Cullin-associated NEDD8-dissociated protein 1
    CLIA Kit for Human Cullin-associated NEDD8-dissociated protein 1
    CLIA Kit for Human Cullin-associated NEDD8-dissociated protein 1
    CLIA Kit for Human Cullin-associated NEDD8-dissociated protein 1
    CLIA Kit for Human Cullin-associated NEDD8-dissociated protein 1
    Polyclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
    Polyclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
    Polyclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
    Polyclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
    Monoclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
    Monoclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
    Monoclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
    Monoclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
    Protein for Human Cullin-associated NEDD8-dissociated protein 1
    Protein for Human Cullin-associated NEDD8-dissociated protein 1
    Protein for Human Cullin-associated NEDD8-dissociated protein 1
    Protein for Human Cullin-associated NEDD8-dissociated protein 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      Ohara O. , Nagase T. , Kikuno R. , Ishikawa K. , Suyama M.
      Submitted (2005-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Adrenal gland.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Testis.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-952
      tissue: Cervix.
      tissue: Testis.
      tissue: Uterus.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Placenta.
    8. 8.
      Bienvenut W.V. , Ramsay A. , Leung H.Y.
      Submitted (2009-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-14 AND 374-382;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Embryonic kidney.
    9. 9.
      Bienvenut W.V. , Waridel P. , Quadroni M.
      Submitted (2009-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-14; 535-548; 668-679; 730-743; 859-873; 958-969 AND 983-990;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Embryonic kidney.
    10. 10.
      "CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex."
      Zheng J. , Yang X. , Harrell J.M. , Ryzhikov S. , Shim E.-H. , Lykke-Andersen K. , Wei N. , Sun H. , Kobayashi R. , Zhang H.
      Mol. Cell10:1519-1526(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;FUNCTION;IDENTIFICATION IN A COMPLEX WITH CUL1 AND RBX1
    11. 11.
      "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases."
      Liu J. , Furukawa M. , Matsumoto T. , Xiong Y.
      Mol. Cell10:1511-1518(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH CUL1 AND RBX1;INTERACTION WITH UNNEDDYLATED CUL1; CUL4A AND CUL5
    12. 12.
      "TIP120A associates with cullins and modulates ubiquitin ligase activity."
      Min K.-W. , Hwang J.-W. , Lee J.-S. , Park Y. , Tamura T.-A. , Yoon J.-B.
      J. Biol. Chem.278:15905-15910(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CUL1; CUL2; CUL3; CUL4A; CUL4B AND RBX1;IDENTIFICATION BY MASS SPECTROMETRY
    13. 13.
      "CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1."
      Lo S.C. , Hannink M.
      Mol. Cell. Biol.26:1235-1244(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CUL3
    14. 14.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-55 AND LYS-971;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression."
      Murata T. , Takayama K. , Katayama S. , Urano T. , Horie-Inoue K. , Ikeda K. , Takahashi S. , Kawazu C. , Hasegawa A. , Ouchi Y. , Homma Y. , Hayashizaki Y. , Inoue S.
      Prostate Cancer Prostatic Dis.13:356-361(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding."
      Mao X. , Gluck N. , Chen B. , Starokadomskyy P. , Li H. , Maine G.N. , Burstein E.
      J. Biol. Chem.286:32355-32365(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CUL2
    21. 21.
      "Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo."
      Chua Y.S. , Boh B.K. , Ponyeam W. , Hagen T.
      PLoS ONE6:E16071-E16071(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CUL2; CUL3; CUL4A AND CUL5;SUBCELLULAR LOCATION
    22. 22.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    24. 24.
      "Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins."
      Pierce N.W. , Lee J.E. , Liu X. , Sweredoski M.J. , Graham R.L. , Larimore E.A. , Rome M. , Zheng N. , Clurman B.E. , Hess S. , Shan S.O. , Deshaies R.J.
      Cell153:206-215(2013) [PubMed] [Europe PMC] [Abstract]
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