Gene name:
CAND1 (KIAA0829;TIP120;TIP120A) ;
Protein name:
Cullin-associated NEDD8-dissociated protein 1 ;
Alternative:
TBP-interacting protein of 120 kDa A (TBP-interacting protein 120A) ;Cullin-associated and neddylation-dissociated protein 1 ;p120 CAND1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Binds unneddylated CUL1, but cannot bind CUL1 once it has been neddylated. Binds CUL2, CUL3, CUL4A, CUL4B and CUL5.
Function:
Enhances transcription from various types of promoters (By similarity). Regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. Prevents neddylation of CUL1 by physically blocking access to the neddylation site. Disrupts interactions between CUL1 and SKP1 and between CUL1 and F-box proteins.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MASASYHISN | LLEKMTSSDK | DFRFMATNDL | MTELQKDSIK | LDDDSERKVV |
100:
KMILKLLEDK | NGEVQNLAVK | CLGPLVSKVK | EYQVETIVDT | LCTNMLSDKE |
150:
QLRDISSIGL | KTVIGELPPA | SSGSALAANV | CKKITGRLTS | AIAKQEDVSV |
200:
QLEALDIMAD | MLSRQGGLLV | NFHPSILTCL | LPQLTSPRLA | VRKRTIIALG |
250:
HLVMSCGNIV | FVDLIEHLLS | ELSKNDSMST | TRTYIQCIAA | ISRQAGHRIG |
300:
EYLEKIIPLV | VKFCNVDDDE | LREYCIQAFE | SFVRRCPKEV | YPHVSTIINI |
350:
CLKYLTYDPN | YNYDDEDEDE | NAMDADGGDD | DDQGSDDEYS | DDDDMSWKVR |
400:
RAAAKCLDAV | VSTRHEMLPE | FYKTVSPALI | SRFKEREENV | KADVFHAYLS |
450:
LLKQTRPVQS | WLCDPDAMEQ | GETPLTMLQS | QVPNIVKALH | KQMKEKSVKT |
500:
RQCCFNMLTE | LVNVLPGALT | QHIPVLVPGI | IFSLNDKSSS | SNLKIDALSC |
550:
LYVILCNHSP | QVFHPHVQAL | VPPVVACVGD | PFYKITSEAL | LVTQQLVKVI |
600:
RPLDQPSSFD | ATPYIKDLFT | CTIKRLKAAD | IDQEVKERAI | SCMGQIICNL |
650:
GDNLGSDLPN | TLQIFLERLK | NEITRLTTVK | ALTLIAGSPL | KIDLRPVLGE |
700:
GVPILASFLR | KNQRALKLGT | LSALDILIKN | YSDSLTAAMI | DAVLDELPPL |
750:
ISESDMHVSQ | MAISFLTTLA | KVYPSSLSKI | SGSILNELIG | LVRSPLLQGG |
800:
ALSAMLDFFQ | ALVVTGTNNL | GYMDLLRMLT | GPVYSQSTAL | THKQSYYSIA |
850:
KCVAALTRAC | PKEGPAVVGQ | FIQDVKNSRS | TDSIRLLALL | SLGEVGHHID |
900:
LSGQLELKSV | ILEAFSSPSE | EVKSAASYAL | GSISVGNLPE | YLPFVLQEIT |
950:
SQPKRQYLLL | HSLKEIISSA | SVVGLKPYVE | NIWALLLKHC | ECAEEGTRNV |
1000:
VAECLGKLTL | IDPETLLPRL | KGYLISGSSY | ARSSVVTAVK | FTISDHPQPI |
1050:
DPLLKNCIGD | FLKTLEDPDL | NVRRVALVTF | NSAAHNKPSL | IRDLLDTVLP |
1100:
HLYNETKVRK | ELIREVEMGP | FKHTVDDGLD | IRKAAFECMY | TLLDSCLDRL |
1150:
DIFEFLNHVE | DGLKDHYDIK | MLTFLMLVRL | STLCPSAVLQ | RLDRLVEPLR |
1200:
ATCTTKVKAN | SVKQEFEKQD | ELKRSAMRAV | AALLTIPEAE | KSPLMSEFQS |
1230:
QISSNPELAA | IFESIQKDSS | STNLESMDTS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Bovine
ELISA Kit for Human Cullin-associated NEDD8-dissociated protein 1
ELISA Kit for Human Cullin-associated NEDD8-dissociated protein 1
ELISA Kit for Human Cullin-associated NEDD8-dissociated protein 1
ELISA Kit for Human Cullin-associated NEDD8-dissociated protein 1
CLIA Kit for Human Cullin-associated NEDD8-dissociated protein 1
CLIA Kit for Human Cullin-associated NEDD8-dissociated protein 1
CLIA Kit for Human Cullin-associated NEDD8-dissociated protein 1
CLIA Kit for Human Cullin-associated NEDD8-dissociated protein 1
Polyclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
Polyclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
Polyclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
Polyclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
Monoclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
Monoclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
Monoclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
Monoclonal Antibody for Human Cullin-associated NEDD8-dissociated protein 1
Protein for Human Cullin-associated NEDD8-dissociated protein 1
Protein for Human Cullin-associated NEDD8-dissociated protein 1
Protein for Human Cullin-associated NEDD8-dissociated protein 1
Protein for Human Cullin-associated NEDD8-dissociated protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Adrenal gland .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Testis .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-952
tissue :
Cervix .
tissue :
Testis .
tissue :
Uterus .
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Nat. Genet.36:40-45(2004)
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue :
Placenta .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-14 AND 374-382;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Embryonic kidney .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-14; 535-548; 668-679; 730-743; 859-873; 958-969 AND 983-990;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Embryonic kidney .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE;FUNCTION;IDENTIFICATION IN A COMPLEX WITH CUL1 AND RBX1
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN A COMPLEX WITH CUL1 AND RBX1;INTERACTION WITH UNNEDDYLATED CUL1; CUL4A AND CUL5
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CUL1; CUL2; CUL3; CUL4A; CUL4B AND RBX1;IDENTIFICATION BY MASS SPECTROMETRY
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CUL3
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-55 AND LYS-971;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
"miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression."
Murata T.
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Takayama K.
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Katayama S.
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Urano T.
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Horie-Inoue K.
,
Ikeda K.
,
Takahashi S.
,
Kawazu C.
,
Hasegawa A.
,
Ouchi Y.
,
Homma Y.
,
Hayashizaki Y.
,
Inoue S.
Prostate Cancer Prostatic Dis.13:356-361(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : INDUCTION
19.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.
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Cited for : INTERACTION WITH CUL2
21.
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Cited for : FUNCTION;INTERACTION WITH CUL2; CUL3; CUL4A AND CUL5;SUBCELLULAR LOCATION
22.
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Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.
"Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins."
Pierce N.W.
,
Lee J.E.
,
Liu X.
,
Sweredoski M.J.
,
Graham R.L.
,
Larimore E.A.
,
Rome M.
,
Zheng N.
,
Clurman B.E.
,
Hess S.
,
Shan S.O.
,
Deshaies R.J.
Cell153:206-215(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : FUNCTION;REACTION MECHANISM
25.
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Cited for : X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) IN COMPLEX WITH CUL1 AND RBX1
26.
"The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation."
Fischer E.S.
,
Scrima A.
,
Bohm K.
,
Matsumoto S.
,
Lingaraju G.M.
,
Faty M.
,
Yasuda T.
,
Cavadini S.
,
Wakasugi M.
,
Hanaoka F.
,
Iwai S.
,
Gut H.
,
Sugasawa K.
,
Thoma N.H.
Cell147:1024-1039(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) IN COMPLEX WITH CUL4B AND RBX1