CADPS ELISA Kit for Human(Homo sapiens) | EIAab.comCADPS ELISA Kit for Human(Homo sapiens) | EIAab.com

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CADPS (Gene name),

Calcium-dependent secretion activator 1 (Protein name ), CAPS1_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

CADPS(CAPS;CAPS1;KIAA1121);

Protein name:

Calcium-dependent secretion activator 1;

Alternative:

Calcium-dependent activator protein for secretion 1(CAPS-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer (By similarity). Interacts with the dopamine receptor DRD2.

Function:

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering.

Subcellular Location:

Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side Cell junction synapse Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2.

Protein Attributes:

Sequence length:

1353

Sequence:

50:

MLDPSSSEEE | SDEIVEEESG | KEVLGSAPSG | ARLSPSRTSE | GSAGSAGLGG |

100:

GGAGAGAGVG | AGGGGGSGAS | SGGGAGGLQP | SSRAGGGRPS | SPSPSVVSEK |

150:

EKEELERLQK | EEEERKKRLQ | LYVFVMRCIA | YPFNAKQPTD | MARRQQKISK |

200:

QQLQTVKDRF | QAFLNGETQI | MADEAFMNAV | QSYYEVFLKS | DRVARMVQSG |

250:

GCSANDSREV | FKKHIEKRVR | SLPEIDGLSK | ETVLSSWMAK | FDAIYRGEED |

300:

PRKQQARMTA | SAASELILSK | EQLYEMFQNI | LGIKKFEHQL | LYNACQLDNP |

350:

DEQAAQIRRE | LDGRLQMADQ | IARERKFPKF | VSKEMENMYI | EELKSSVNLL |

400:

MANLESMPVS | KGGEFKLQKL | KRSHNASIID | MGEESENQLS | KSDVVLSFSL |

450:

EVVIMEVQGL | KSLAPNRIVY | CTMEVEGGEK | LQTDQAEASK | PTWGTQGDFS |

500:

TTHALPAVKV | KLFTESTGVL | ALEDKELGRV | ILHPTPNSPK | QSEWHKMTVS |

550:

KNCPDQDLKI | KLAVRMDKPQ | NMKHSGYLWA | IGKNVWKRWK | KRFFVLVQVS |

600:

QYTFAMCSYR | EKKAEPQELL | QLDGYTVDYT | DPQPGLEGGR | AFFNAVKEGD |

650:

TVIFASDDEQ | DRILWVQAMY | RATGQSHKPV | PPTQVQKLNA | KGGNVPQLDA |

700:

PISQFYADRA | QKHGMDEFIS | SNPCNFDHAS | LFEMVQRLTL | DHRLNDSYSC |

750:

LGWFSPGQVF | VLDEYCARNG | VRGCHRHLCY | LRDLLERAEN | GAMIDPTLLH |

800:

YSFAFCASHV | HGNRPDGIGT | VTVEEKERFE | EIKERLRVLL | ENQITHFRYC |

850:

FPFGRPEGAL | KATLSLLERV | LMKDIVTPVP | QEEVKTVIRK | CLEQAALVNY |

900:

SRLSEYAKIE | ENQKDAENVG | RLITPAKKLE | DTIRLAELVI | EVLQQNEEHH |

950:

AEPHVDKGEA | FAWWSDLMVE | HAETFLSLFA | VDMDAALEVQ | PPDTWDSFPL |

1000:

FQLLNDFLRT | DYNLCNGKFH | KHLQDLFAPL | VVRYVDLMES | SIAQSIHRGF |

1050:

ERESWEPVKS | LTSNLPNVNL | PNVNLPKVPN | LPVNIPLGIP | QMPTFSAPSW |

1100:

MAAIYDADNG | SGTSEDLFWK | LDALQTFIRD | LHWPEEEFGK | HLEQRLKLMA |

1150:

SDMIESCVKR | TRIAFEVKLQ | KTSRSTDFRV | PQSICTMFNV | MVDAKAQSTK |

1200:

LCSMEMGQEH | QYHSKIDELI | EETVKEMITL | LVAKFVTILE | GVLAKLSRYD |

1250:

EGTLFSSFLS | FTVKAASKYV | DVPKPGMDVA | DAYVTFVRHS | QDVLRDKVNE |

1300:

EMYIERLFDQ | WYNSSMNVIC | TWLTDRMDLQ | LHIYQLKTLI | RMVKKTYRDF |

1350:

RLQGVLDSTL | NSKTYETIRN | RLTVEEATAS | VSEGGGLQGI | SMKDSDEEDE |

1353:

EDD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Pfam:

STRING:

9606.ENSP00000373215

MIM:

KEGG:

UniGene:

SMR:

Uniprot:

FOR

ELISA Kit for Human Calcium-dependent secretion activator 1

ELISA Kit for Human Calcium-dependent secretion activator 1

ELISA Kit for Human Calcium-dependent secretion activator 1

CLIA Kit for Human Calcium-dependent secretion activator 1

CLIA Kit for Human Calcium-dependent secretion activator 1

CLIA Kit for Human Calcium-dependent secretion activator 1

Polyclonal Antibody for Human Calcium-dependent secretion activator 1

Polyclonal Antibody for Human Calcium-dependent secretion activator 1

Polyclonal Antibody for Human Calcium-dependent secretion activator 1

Monoclonal Antibody for Human Calcium-dependent secretion activator 1

Monoclonal Antibody for Human Calcium-dependent secretion activator 1

Monoclonal Antibody for Human Calcium-dependent secretion activator 1

Protein for Human Calcium-dependent secretion activator 1

Protein for Human Calcium-dependent secretion activator 1

Protein for Human Calcium-dependent secretion activator 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family."
Cisternas F.A. , Vincent J.B. , Scherer S.W. , Ray P.N.
Genomics81:279-291(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
2.

"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
Hirosawa M. , Nagase T. , Ishikawa K. , Kikuno R. , Nomura N. , Ohara O.
DNA Res.6:329-336(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
3.

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
4.

"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-1353 (ISOFORM 3)
tissue: Amygdala.
6.

"Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis."
Ann K. , Kowalchyk J.A. , Loyet K.M. , Martin T.F.J.
J. Biol. Chem.272:19637-19640(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1108-1353 (ISOFORM 4)
tissue: Brain.
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1109-1353 (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 320-1353 (ISOFORM 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1121-1353
tissue: PNS.
tissue: Skin.
8.

"Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)."
Binda A.V. , Kabbani N. , Levenson R.
Biochem. Pharmacol.69:1451-1461(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DRD2
9.

"Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)."
RIKEN structural genomics initiative (RSGI)
Submitted (2004-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 522-634

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