Cadps ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCadps ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Cadps(Gene name) > Rat

Cadps (Gene name),

Calcium-dependent secretion activator 1 (Protein name ), CAPS1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cadps(Caps;Caps1);

Protein name:

Calcium-dependent secretion activator 1;

Alternative:

Calcium-dependent activator protein for secretion 1(CAPS-1;rCAPS);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with the dopamine receptor DRD2 (By similarity). Homodimer.

Function:

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering.

Subcellular Location:

Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side Cell junction synapse Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2.

Protein Attributes:

Sequence length:

1289

Sequence:

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1150:

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1250:

1289:

YETIRNRLTV | EERTASVSEG | GGLQGISMKD | SDEEDEEDD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:26989

SMR:

Q62717

String:

Q62717

UniGene:

Rn.88197

Pfam:

PF06292

STRING:

10116.ENSRNOP00000057939

Uniprot:

Q62717

FOR

ELISA Kit for Rat Calcium-dependent secretion activator 1

CLIA Kit for Rat Calcium-dependent secretion activator 1

Polyclonal Antibody for Rat Calcium-dependent secretion activator 1

Monoclonal Antibody for Rat Calcium-dependent secretion activator 1

Protein for Rat Calcium-dependent secretion activator 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis."
Ann K. , Kowalchyk J.A. , Loyet K.M. , Martin T.F.J.
J. Biol. Chem.272:19637-19640(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 103-109; 560-595; 810-821 AND 1155-1183;CALCIUM-BINDING;TISSUE SPECIFICITY
2.

"A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells."
Walent J.H. , Porter B.W. , Martin T.F.J.
Cell70:765-775(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;SUBUNIT
3.

"Docked secretory vesicles undergo Ca2+-activated exocytosis in a cell-free system."
Martin T.F.J. , Kowalchyk J.A.
J. Biol. Chem.272:14447-14453(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis."
Loyet K.M. , Kowalchyk J.A. , Chaudhary A. , Chen J. , Prestwich G.D. , Martin T.F.J.
J. Biol. Chem.273:8337-8343(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHOINOSIDE-BINDING
5.

"CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis."
Berwin B. , Floor E. , Martin T.F.J.
Neuron21:137-145(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
6.

"Differential regulation of exocytosis by calcium and CAPS in semi-intact synaptosomes."
Tandon A. , Bannykh S. , Kowalchyk J.A. , Banerjee A. , Martin T.F.J. , Balch W.E.
Neuron21:147-154(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Rapid regulated dense-core vesicle exocytosis requires the CAPS protein."
Rupnik M. , Kreft M. , Sikdar S.K. , Grilc S. , Romih R. , Zupancic G. , Martin T.F.J. , Zorec R.
Proc. Natl. Acad. Sci. U.S.A.97:5627-5632(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
8.

"Membrane association domains in Ca2+-dependent activator protein for secretion mediate plasma membrane and dense-core vesicle binding required for Ca2+-dependent exocytosis."
Grishanin R.N. , Klenchin V.A. , Loyet K.M. , Kowalchyk J.A. , Ann K. , Martin T.F.J.
J. Biol. Chem.277:22025-22034(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DOMAIN;PHOSPHOINOSIDE-BINDING;MUTAGENESIS OF LYS-531; 537-TRP--ARG-540; 558-ARG--LYS-561 AND LYS-561
9.

"A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function."
Speidel D. , Varoqueaux F. , Enk C. , Nojiri M. , Grishanin R.N. , Martin T.F.J. , Hofmann K. , Brose N. , Reim K.
J. Biol. Chem.278:52802-52809(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
10.

"CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP2 binding protein."
Grishanin R.N. , Kowalchyk J.A. , Klenchin V.A. , Ann K. , Earles C.A. , Chapman E.R. , Gerona R.R.L. , Martin T.F.J.
Neuron43:551-562(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF GLY-476

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