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Index > Protein center > Cadps2(Gene name) > Mouse
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  • Cadps2 (Gene name),
  • Calcium-dependent secretion activator 2 (Protein name ),  CAPS2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Cadps2(Caps2);
    Protein name:
    Calcium-dependent secretion activator 2;
    Alternative:
    Calcium-dependent activator protein for secretion 2(CAPS-2);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with the dopamine receptor DRD2.
    Function:
    Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles.
    Subcellular Location:
    Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side Cell junction synapse Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.
    Protein Attributes:
    Sequence length:
    1297
    Sequence:
    50:
    MLDPSSSEEE | SDEGLEEESR | EVLVAPGVSQ | RAPPAAAREG | RRDAPGRSGG | 
    100:
    GSGGGAARPV | SPSPSVLSEG | RNEPELQLDE | EQERRIRLQL | YVFVVRCIAY | 
    150:
    PFNAKQPTDM | ARRQQKLNKQ | QLQLLKERFQ | AFLNGETQIV | ADEAFCNAVR | 
    200:
    SYYEVFLKSD | RVARMVQSGG | CSANDFREVF | KKNIEKRVRS | LPEIDGLSKE | 
    250:
    TVLSSWIAKY | DAIYRGEEDL | CKQPNRMTLS | AVSELILSKE | QLYEMFQQIL | 
    300:
    GIKKLEHQLL | YNACQLDNAD | EQAAQIRREL | DGRLQLAEKM | AKERRFPRFI | 
    350:
    SKEMESMYIE | ELRASVNLLM | ANLESLPVSK | GGPEFKLQKL | KRSQNSAFLD | 
    400:
    LGDENEIQLS | KSDVVLSFTL | EIVIMEVQGL | KSVAPNRIVY | CTMEVEGGEK | 
    450:
    LQTDQAEASR | PQWGTQGDFN | TTHPRPVVKV | KLFTESTGVL | ALEDKELGRV | 
    500:
    VLYPTSNSSK | SAELHRMTVP | KNSQDSDLKI | KLAVRMDKPA | HMKHSGYLYA | 
    550:
    LGQKVWKRWK | KRYFVLVQVS | QYTFAMCSYR | EKKSEPQELM | QLEGYTVDYT | 
    600:
    DPHPGLQGGQ | VFFNAVKEGD | TVIFASDDEQ | DRILWVQAMY | RATGQSYKPV | 
    650:
    PAVQSQKLNP | KGGALHADAQ | LYADRFQKHG | MDEFISASPC | KLDHAFLFRI | 
    700:
    LQRQTLDHRL | NDSYSCLGWF | SPGQVFVLDE | YCARYGVRGC | HRHLCYLTEL | 
    750:
    MEHSENGAVI | DPTLLHYSFA | FCASHVHGNR | PDGIGTVSVE | EKERFEEIKD | 
    800:
    RLSSLLENQI | SHFRYCFPFG | RPEGALKATL | SLLERVLMKD | IATPIPAEEV | 
    850:
    KKVVRKCLEK | AALINYTRLT | EYAKIEETMN | QATPARKLEE | VLHLAELCIE | 
    900:
    VLQQNEEHHA | EGREAFAWWP | DLLAEHAEKF | WALFTVDMDT | ALEAQPQDSW | 
    950:
    DSFPLFQLLN | NFLRNDTLLC | NGKFHKHLQE | IFVPLVVRYV | DLMESAIAQS | 
    1000:
    IHRGFEQETW | QPVKNIANSL | PNVALPKVPS | LPLNLPQIPS | FSTPPWMASL | 
    1050:
    YESTNGSTTS | EDLFWKLDAL | QMFVFDLHWP | EQEFAHHLEQ | RLKLMASDMI | 
    1100:
    EACVKRTRTA | FELKLQKANK | TTDLRIPASV | CTMFNVLVDA | KKQSTKLCAL | 
    1150:
    DGGQEQQYHS | KIDDLIDNTV | KEIIALLVSK | FVSVLEGVLS | KLSRYDEGTF | 
    1200:
    FSSILSFTVK | AAAKYVDVPK | PGMDLADTYI | MFVRQNQDIL | REKVNEEMYI | 
    1250:
    EKLFDQWYSN | SMKVICVWLA | DRLDLQLHIY | QLKTLIKIVK | KTYRDFRLQG | 
    1297:
    VLEGTLNSKT | YDTLHRRLTV | EEATASVSEG | GGLQGITMKD | SDEEEEG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Calcium-dependent secretion activator 2
    ELISA Kit for Mouse Calcium-dependent secretion activator 2
    CLIA Kit for Mouse Calcium-dependent secretion activator 2
    CLIA Kit for Mouse Calcium-dependent secretion activator 2
    Polyclonal Antibody for Mouse Calcium-dependent secretion activator 2
    Polyclonal Antibody for Mouse Calcium-dependent secretion activator 2
    Monoclonal Antibody for Mouse Calcium-dependent secretion activator 2
    Monoclonal Antibody for Mouse Calcium-dependent secretion activator 2
    Protein for Mouse Calcium-dependent secretion activator 2
    Protein for Mouse Calcium-dependent secretion activator 2

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family."
      Cisternas F.A. , Vincent J.B. , Scherer S.W. , Ray P.N.
      Genomics81:279-291(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    2. 2.
      "The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival."
      Sadakata T. , Mizoguchi A. , Sato Y. , Katoh-Semba R. , Fukuda M. , Mikoshiba K. , Furuichi T.
      J. Neurosci.24:43-52(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
      strain: C57BL/6J.
      tissue: Cerebellum.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 6 AND 7)
      strain: C57BL/6J.
      tissue: Adipose tissue.
      tissue: Hypothalamus.
    4. 4.
      "Differentially expressed mRNA in mouse cerebellum during postnatal development."
      Radrizzani M. , Cafferata E. , Vila-Ortiz G. , Costanzo R.V. , Ortega M.J. , Gonzalez-Guerrico A. , Di Tella M. , Pivetta O. , Carminatti H. , Santa-Coloma T.
      Submitted (2001-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-1297 (ISOFORM 2)
      strain: C57BL/6.
      tissue: Cerebellum.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-1297 (ISOFORM 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-1297 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 313-1297 (ISOFORM 6)
      strain: Czech II.
      strain: FVB/N.
      tissue: Mammary tumor.
      tissue: Salivary gland.
    6. 6.
      "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function."
      Speidel D. , Varoqueaux F. , Enk C. , Nojiri M. , Grishanin R.N. , Martin T.F.J. , Hofmann K. , Brose N. , Reim K.
      J. Biol. Chem.278:52802-52809(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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