Gene name:
Cadps2 (Caps2) ;
Protein name:
Calcium-dependent secretion activator 2 ;
Alternative:
Calcium-dependent activator protein for secretion 2 (CAPS-2) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer. Interacts with the dopamine receptor DRD2.
Function:
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles.
Subcellular Location:
Cytoplasmic vesicle membrane
Peripheral membrane protein
Cytoplasmic side
Cell junction
synapse
Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.
Protein Attributes:
50:
MLDPSSSEEE | SDEGLEEESR | EVLVAPGVSQ | RAPPAAAREG | RRDAPGRSGG |
100:
GSGGGAARPV | SPSPSVLSEG | RNEPELQLDE | EQERRIRLQL | YVFVVRCIAY |
150:
PFNAKQPTDM | ARRQQKLNKQ | QLQLLKERFQ | AFLNGETQIV | ADEAFCNAVR |
200:
SYYEVFLKSD | RVARMVQSGG | CSANDFREVF | KKNIEKRVRS | LPEIDGLSKE |
250:
TVLSSWIAKY | DAIYRGEEDL | CKQPNRMTLS | AVSELILSKE | QLYEMFQQIL |
300:
GIKKLEHQLL | YNACQLDNAD | EQAAQIRREL | DGRLQLAEKM | AKERRFPRFI |
350:
SKEMESMYIE | ELRASVNLLM | ANLESLPVSK | GGPEFKLQKL | KRSQNSAFLD |
400:
LGDENEIQLS | KSDVVLSFTL | EIVIMEVQGL | KSVAPNRIVY | CTMEVEGGEK |
450:
LQTDQAEASR | PQWGTQGDFN | TTHPRPVVKV | KLFTESTGVL | ALEDKELGRV |
500:
VLYPTSNSSK | SAELHRMTVP | KNSQDSDLKI | KLAVRMDKPA | HMKHSGYLYA |
550:
LGQKVWKRWK | KRYFVLVQVS | QYTFAMCSYR | EKKSEPQELM | QLEGYTVDYT |
600:
DPHPGLQGGQ | VFFNAVKEGD | TVIFASDDEQ | DRILWVQAMY | RATGQSYKPV |
650:
PAVQSQKLNP | KGGALHADAQ | LYADRFQKHG | MDEFISASPC | KLDHAFLFRI |
700:
LQRQTLDHRL | NDSYSCLGWF | SPGQVFVLDE | YCARYGVRGC | HRHLCYLTEL |
750:
MEHSENGAVI | DPTLLHYSFA | FCASHVHGNR | PDGIGTVSVE | EKERFEEIKD |
800:
RLSSLLENQI | SHFRYCFPFG | RPEGALKATL | SLLERVLMKD | IATPIPAEEV |
850:
KKVVRKCLEK | AALINYTRLT | EYAKIEETMN | QATPARKLEE | VLHLAELCIE |
900:
VLQQNEEHHA | EGREAFAWWP | DLLAEHAEKF | WALFTVDMDT | ALEAQPQDSW |
950:
DSFPLFQLLN | NFLRNDTLLC | NGKFHKHLQE | IFVPLVVRYV | DLMESAIAQS |
1000:
IHRGFEQETW | QPVKNIANSL | PNVALPKVPS | LPLNLPQIPS | FSTPPWMASL |
1050:
YESTNGSTTS | EDLFWKLDAL | QMFVFDLHWP | EQEFAHHLEQ | RLKLMASDMI |
1100:
EACVKRTRTA | FELKLQKANK | TTDLRIPASV | CTMFNVLVDA | KKQSTKLCAL |
1150:
DGGQEQQYHS | KIDDLIDNTV | KEIIALLVSK | FVSVLEGVLS | KLSRYDEGTF |
1200:
FSSILSFTVK | AAAKYVDVPK | PGMDLADTYI | MFVRQNQDIL | REKVNEEMYI |
1250:
EKLFDQWYSN | SMKVICVWLA | DRLDLQLHIY | QLKTLIKIVK | KTYRDFRLQG |
1297:
VLEGTLNSKT | YDTLHRRLTV | EEATASVSEG | GGLQGITMKD | SDEEEEG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Calcium-dependent secretion activator 2
ELISA Kit for Mouse Calcium-dependent secretion activator 2
CLIA Kit for Mouse Calcium-dependent secretion activator 2
CLIA Kit for Mouse Calcium-dependent secretion activator 2
Polyclonal Antibody for Mouse Calcium-dependent secretion activator 2
Polyclonal Antibody for Mouse Calcium-dependent secretion activator 2
Monoclonal Antibody for Mouse Calcium-dependent secretion activator 2
Monoclonal Antibody for Mouse Calcium-dependent secretion activator 2
Protein for Mouse Calcium-dependent secretion activator 2
Protein for Mouse Calcium-dependent secretion activator 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
strain :
C57BL/6J .
tissue :
Cerebellum .
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 6 AND 7)
strain :
C57BL/6J .
tissue :
Adipose tissue .
tissue :
Hypothalamus .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 31-1297 (ISOFORM 2)
strain :
C57BL/6 .
tissue :
Cerebellum .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-1297 (ISOFORM 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-1297 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 313-1297 (ISOFORM 6)
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Czech II .
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FVB/N .
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Mammary tumor .
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Salivary gland .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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Neuron46:75-88(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY