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Index > Protein center > Casp9(Gene name) > Mouse
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  • Casp9 (Gene name),
  • Caspase-9 (Protein name ),  CASP9_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    Casp9(Mch6);
    Protein name:
    Caspase-9(CASP-9);
    Alternative:
    Apoptotic protease-activating factor 3(APAF-3);Apoptotic protease Mch-6;ICE-like apoptotic protease 6(ICE-LAP6);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts (inactive form) with EFHD2. Interacts with HAX1. Interacts with BIRC2/c-IAP1, XIAP/BIRC4, BIRC5/survivin, BIRC6/bruce and BIRC7/livin. Interacts with ABL1 (via SH3 domain); the interaction is direct and increased in the response of cells to genotoxic stress and ABL1/c-Abl activation.
    Function:
    Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    454
    Sequence:
    50:
    MDEADRQLLR | RCRVRLVSEL | QVAELWDALL | SRELFTRDMI | EDIQQAGSGS | 
    100:
    RRDQARQLVT | DLETRGRQAL | PLFISCLEDT | GQGTLASLLQ | SGRQAAKQDP | 
    150:
    EAVKPLDHLV | PVVLGPMGLT | AKEQRVVKLD | PSQPAVGNLT | PVVLGPEELW | 
    200:
    PARLKPEVLR | PETPRPVDIG | SGGAHDVCVP | GKIRGHADMA | YTLDSDPCGH | 
    250:
    CLIINNVNFC | PSSGLGTRTG | SNLDRDKLEH | RFRWLRFMVE | VKNDLTAKKM | 
    300:
    VTALMEMAHR | NHRALDCFVV | VILSHGCQAS | HLQFPGAVYG | TDGCSVSIEK | 
    350:
    IVNIFNGSGC | PSLGGKPKLF | FIQACGGEQK | DHGFEVACTS | SQGRTLDSDS | 
    400:
    EPDAVPYQEG | PRPLDQLDAV | SSLPTPSDIL | VSYSTFPGFV | SWRDKKSGSW | 
    450:
    YIETLDGILE | QWARSEDLQS | LLLRVANAVS | AKGTYKQIPG | CFNFLRKKLF | 
    454:
    FKTS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CASP-9
    Cat.:
    E0627h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Mouse CASP-9
    Cat.:
    E0627m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse CASP-9
    Cat.:
    U0627m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse CASP-9
    Cat.:
    U0627h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse CASP-9
    Cat.:
    P0627Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse CASP-9
    Cat.:
    P0627Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse CASP-9
    Monoclonal Antibody for Mouse CASP-9
    Protein for Mouse CASP-9
    Protein for Mouse CASP-9

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Lung.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    5. 5.
      "c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage."
      Raina D. , Pandey P. , Ahmad R. , Bharti A. , Ren J. , Kharbanda S. , Weichselbaum R. , Kufe D.
      J. Biol. Chem.280:11147-11151(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-191 BY ABL1
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