CAV1 ELISA Kit for Human(Homo sapiens) | EIAab.comCAV1 ELISA Kit for Human(Homo sapiens)

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CAV1 (Gene name),

Caveolin-1 (Protein name ), CAV1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (2)

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Gene name:

CAV1(CAV);

Protein name:

Caveolin-1;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP (By similarity). Interacts with BMX and BTK.

Function:

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

Subcellular Location:

Golgi apparatus membrane Peripheral membrane protein Cell membrane Peripheral membrane protein Membrane caveola Peripheral membrane protein Membrane raft Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.

Protein Attributes:

Sequence length:

178

Sequence:

50:

100:

150:

178:

YVHTVCDPLF | EAVGKIFSNV | RINLQKEI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.74034

Pfam:

PF01146

STRING:

9606.ENSP00000339191

String:

Q03135

KEGG:

hsa:857

MIM:

601047

Uniprot:

Q03135

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ELISA Kit for Human Caveolin-1

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E0214h

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ELISA Kit for Human Caveolin-1

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E0214r

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96T

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ELISA Kit for Human Caveolin-1

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E0214b

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ELISA Kit for Human Caveolin-1

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E0214m

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ELISA Kit for Human Caveolin-1

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E0214p

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96T

ELISA Kit for Human Caveolin-1

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E0214c

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96T

ELISA Kit for Human Caveolin-1

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ELISA Kit for Human Caveolin-1

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E0214d

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96T

CLIA Kit for Human Caveolin-1

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U0214p

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96T

CLIA Kit for Human Caveolin-1

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U0214r

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96T

CLIA Kit for Human Caveolin-1

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U0214b

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96T

CLIA Kit for Human Caveolin-1

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U0214m

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96T

CLIA Kit for Human Caveolin-1

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U0214c

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96T

CLIA Kit for Human Caveolin-1

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U0214h

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96T

CLIA Kit for Human Caveolin-1

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U0214d

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CLIA Kit for Human Caveolin-1

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Polyclonal Antibody for Human Caveolin-1

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P0214Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Caveolin-1

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P0214Rb-m

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Polyclonal Antibody for Human Caveolin-1

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P0214Rb-r

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Monoclonal Antibody for Human Caveolin-1

Protein for Human Caveolin-1

R&D Technical Data

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Precision

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Recovery

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Linearity

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Citations

[1].

"Network-pharmacology-based identification of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis"

B Yang, N Wang, SQ Wang, et al.

From:Biomedicine & Pharmacotherapy

[2].

"Caveolin-1, Ring finger protein 213, and endothelial function in Moyamoya disease"

Bang O Y, Chung J W, Kim S J, et al.

From:International Journal of Stroke

References

1.

"Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia."
Lee H. , Park D.S. , Razani B. , Russell R.G. , Pestell R.G. , Lisanti M.P.
Am. J. Pathol.161:1357-1369(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-132
2.

"The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles."
Glenney J.R. Jr.
FEBS Lett.314:45-48(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Lung.
3.

"Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines."
Hurlstone A.F. , Reid G. , Reeves J.R. , Fraser J. , Strathdee G. , Rahilly M. , Parkinson E.K. , Black D.M.
Oncogene18:1881-1890(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines."
Engelman J.A. , Zhang X.L. , Lisanti M.P.
FEBS Lett.448:221-230(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Lung.
7.

"N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes."
Vainonen J.P. , Aboulaich N. , Turkina M.V. , Stralfors P. , Vener A.V.
Biochem. Biophys. Res. Commun.320:480-486(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-66;SUBCELLULAR LOCATION;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;PHOSPHORYLATION AT SER-37;CLEAVAGE OF INITIATOR METHIONINE (ISOFORM 2);ACETYLATION AT ALA-2 (ISOFORM 2);PHOSPHORYLATION AT SER-6 (ISOFORM 2)
tissue: Adipose tissue.
8.

"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
Aboulaich N. , Vainonen J.P. , Stralfors P. , Vener A.V.
Biochem. J.383:237-248(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 58-65
tissue: Adipocyte.
9.

"Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo."
Li S. , Seitz R. , Lisanti M.P.
J. Biol. Chem.271:3863-3868(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-6; TYR-14 AND TYR-25
10.

"Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx."
Vargas L. , Nore B.F. , Berglof A. , Heinonen J.E. , Mattsson P.T. , Smith C.I. , Mohamed A.J.
J. Biol. Chem.277:9351-9357(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BMX AND BTK
11.

"Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex."
Eberle H.B. , Serrano R.L. , Fuellekrug J. , Schlosser A. , Lehmann W.D. , Lottspeich F. , Kaloyanova D. , Wieland F.T. , Helms J.B.
J. Cell Sci.115:827-838(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GLIPR2
tissue: Brain.
12.

"c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14."
Sanguinetti A.R. , Mastick C.C.
Cell. Signal.15:289-298(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-14
13.

"Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN."
Schilling K. , Opitz N. , Wiesenthal A. , Oess S. , Tikkanen R. , Mueller-Esterl W. , Icking A.
Mol. Biol. Cell17:3870-3880(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOSTRIN
14.

"The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1."
Parr R.D. , Storey S.M. , Mitchell D.M. , McIntosh A.L. , Zhou M. , Mir K.D. , Ball J.M.
J. Virol.80:2842-2854(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ROTAVIRUS A NSP4
15.

"Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1."
Ohnuma K. , Uchiyama M. , Yamochi T. , Nishibashi K. , Hosono O. , Takahashi N. , Kina S. , Tanaka H. , Lin X. , Dang N.H. , Morimoto C.
J. Biol. Chem.282:10117-10131(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DPP4;SUBCELLULAR LOCATION
16.

"Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy."
Kim C.A. , Delepine M. , Boutet E. , El Mourabit H. , Le Lay S. , Meier M. , Nemani M. , Bridel E. , Leite C.C. , Bertola D.R. , Semple R.K. , O'Rahilly S. , Dugail I. , Capeau J. , Lathrop M. , Magre J.
J. Clin. Endocrinol. Metab.93:1129-1134(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CGL3
17.

"Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia."
Cao H. , Alston L. , Ruschman J. , Hegele R.A.
Lipids Health Dis.7:3-3(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LCCNS
18.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND LYS-5;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
22.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.

"Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension."
Austin E.D. , Ma L. , LeDuc C. , Berman Rosenzweig E. , Borczuk A. , Phillips J.A. III , Palomero T. , Sumazin P. , Kim H.R. , Talati M.H. , West J. , Loyd J.E. , Chung W.K.
Circ. Cardiovasc. Genet.5:336-343(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PPH3
25.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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