Protein name:
E3 ubiquitin-protein ligase CBL-C ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with Ubiquitin-conjugating enzyme E2 UBE2D2 and UBE2D3. Interacts with EGFR (tyrosine phosphorylated). Interacts with the SH3 domain proteins LYN and CRK. Interacts (via RING-type zinc finger) with TGFB1I1 (via LIM zinc-binding domain 2); the interaction is direct and enhances the E3 activity. Interacts directly with RET (inactive) and CD2AP; dissociates from RET upon RET activation by GDNF which also increases the interaction with CD2AP suggesting dissociation as CBLC:CD2AP complex. Interacts with SRC; the interaction is enhanced when SRC is phosphorylated at 'Tyr-419'.
Function:
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
Subcellular Location:
N/A
Protein Attributes:
50:
MAAATAPQGW | QWGEPRALGR | AVKLLQRLEE | QCRDLRLFVG | PPSLRDLLPR |
100:
TAQLLREVAK | ARSDKTRGDP | EGPGGAGDFL | VIYLTNLEAK | GRQVAELLPH |
150:
RGKKDANQDV | FPEGSRFRRQ | LAKLALIFSH | MHAELSALFP | EGKYCGHLYQ |
200:
ITKGSANTFW | RENCGVRCVL | PWAEFQSLLC | SCHPVEPGPI | MQALRSTLDL |
250:
TCSGHVSVFE | FDIFTRLFQP | WPTLLKNWQL | LAVNHPGYMA | FLTYDEVQTR |
300:
LQAYRDKPGS | YIFRPSCTRL | GQWAIGYVSS | NGSILQTIPL | NKPLLQVLLK |
350:
GQKDGIFLYP | DGKNHNPDLT | ELCRAVLNQC | IQVSQEQLQL | YQAMNSTFEL |
400:
CKICTERDKD | VRIEPCGHLL | CSCCLAAWQH | SDSQTCPFCR | CEIKGREAVS |
450:
ICQAQERSME | VRTTAGDSGD | NCHQEAAEWK | LESVTPSAPP | LPPEVPCPQR |
497:
PQNKGWLTLA | PFTLPRLRPP | LPLPKMASVL | WEVTSRPQVR | EGATESS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Rat E3 ubiquitin-protein ligase CBL-C
ELISA Kit for Rat E3 ubiquitin-protein ligase CBL-C
ELISA Kit for Rat E3 ubiquitin-protein ligase CBL-C
CLIA Kit for Rat E3 ubiquitin-protein ligase CBL-C
CLIA Kit for Rat E3 ubiquitin-protein ligase CBL-C
CLIA Kit for Rat E3 ubiquitin-protein ligase CBL-C
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase CBL-C
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase CBL-C
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase CBL-C
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase CBL-C
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase CBL-C
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase CBL-C
Protein for Rat E3 ubiquitin-protein ligase CBL-C
Protein for Rat E3 ubiquitin-protein ligase CBL-C
Protein for Rat E3 ubiquitin-protein ligase CBL-C
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN RET STABILITY;INTERACTION WITH CD2AP AND RET