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Index > Protein center > CPA4(Gene name) > Human
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  • CPA4 (Gene name),
  • Carboxypeptidase A4 (Protein name ),  CBPA4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CPA4(UNQ694/PRO1339;CPA3);
    Protein name:
    Carboxypeptidase A4;
    Alternative:
    Carboxypeptidase A3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with LXN.
    Function:
    Metalloprotease that could be involved in the histone hyperacetylation pathway.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    421
    Sequence:
    50:
    MRWILFIGAL | IGSSICGQEK | FFGDQVLRIN | VRNGDEISKL | SQLVNSNNLK | 
    100:
    LNFWKSPSSF | NRPVDVLVPS | VSLQAFKSFL | RSQGLEYAVT | IEDLQALLDN | 
    150:
    EDDEMQHNEG | QERSSNNFNY | GAYHSLEAIY | HEMDNIAADF | PDLARRVKIG | 
    200:
    HSFENRPMYV | LKFSTGKGVR | RPAVWLNAGI | HSREWISQAT | AIWTARKIVS | 
    250:
    DYQRDPAITS | ILEKMDIFLL | PVANPDGYVY | TQTQNRLWRK | TRSRNPGSSC | 
    300:
    IGADPNRNWN | ASFAGKGASD | NPCSEVYHGP | HANSEVEVKS | VVDFIQKHGN | 
    350:
    FKGFIDLHSY | SQLLMYPYGY | SVKKAPDAEE | LDKVARLAAK | ALASVSGTEY | 
    400:
    QVGPTCTTVY | PASGSSIDWA | YDNGIKFAFT | FELRDTGTYG | FLLPANQIIP | 
    421:
    TAEETWLGLK | TIMEHVRDNL | Y
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    Pfam:
    KEGG:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Carboxypeptidase A4
    ELISA Kit for Human Carboxypeptidase A4
    CLIA Kit for Human Carboxypeptidase A4
    CLIA Kit for Human Carboxypeptidase A4
    Polyclonal Antibody for Human Carboxypeptidase A4
    Polyclonal Antibody for Human Carboxypeptidase A4
    Monoclonal Antibody for Human Carboxypeptidase A4
    Monoclonal Antibody for Human Carboxypeptidase A4
    Protein for Human Carboxypeptidase A4
    Protein for Human Carboxypeptidase A4

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells."
      Huang H. , Reed C.P. , Zhang J.S. , Shridhar V. , Wang L. , Smith D.I.
      Cancer Res.59:2981-2988(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INDUCTION
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    4. 4.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Pancreas.
    6. 6.
      "The novel imprinted carboxypeptidase A4 gene (CPA4) in the 7q32 imprinting domain."
      Kayashima T. , Yamasaki K. , Yamada T. , Sakai H. , Miwa N. , Ohta T. , Yoshiura K. , Matsumoto N. , Nakane Y. , Kanetake H. , Ishino F. , Niikawa N. , Kishino T.
      Hum. Genet.112:220-226(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IMPRINTING
    7. 7.
      "Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing."
      Tanco S. , Zhang X. , Morano C. , Aviles F.X. , Lorenzo J. , Fricker L.D.
      J. Biol. Chem.285:18385-18396(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;SUBSTRATE SPECIFICITY;BIOPHYSICOCHEMICAL PROPERTIES
    8. 8.
      "Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin."
      Garcia-Castellanos R. , Bonet-Figueredo R. , Pallares I. , Ventura S. , Aviles F.X. , Vendrell J. , Gomis-Rueth F.-X.
      Cell. Mol. Life Sci.62:1996-2014(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 19-421 IN COMPLEX WITH LXN AND ZINC IONS;GLYCOSYLATION AT ASN-260;DISULFIDE BOND
    9. 9.
      "Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin."
      Pallares I. , Bonet R. , Garcia-Castellanos R. , Ventura S. , Aviles F.X. , Vendrell J. , Gomis-Rueth F.-X.
      Proc. Natl. Acad. Sci. U.S.A.102:3978-3983(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 114-421 IN COMPLEX WITH LXN;GLYCOSYLATION AT ASN-260;DISULFIDE BOND
    10. 10.
      "Crystal structure of novel metallocarboxypeptidase inhibitor from marine mollusk Nerita versicolor in complex with human carboxypeptidase A4."
      Covaleda G. , del Rivero M.A. , Chavez M.A. , Aviles F.X. , Reverter D.
      J. Biol. Chem.287:9250-9258(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 112-421 IN COMPLEX WITH N.VERSICOLOR MCPI AND ZINC;COFACTOR;SUBUNIT;ENZYME REGULATION;ACTIVE SITE;DISULFIDE BOND
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