Cbx7 ELISA Kit for Mouse(Mus musculus) | EIAab.comCbx7 ELISA Kit for Mouse(Mus musculus)

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Cbx7 (Gene name),

Chromobox protein homolog 7 (Protein name ), CBX7_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cbx7(D15Ertd417e);

Protein name:

Chromobox protein homolog 7;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of a PRC1-like complex (By similarity). Interacts with RING1. Interacts with RNF2/RING1B. Interacts with PCGF1, PCGF2, PCGF3, PCGF5 and PCGF6.

Function:

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

Subcellular Location:

Nucleus Detected in faculative heterochromatin and on the inactivated X-chromosome in females.

Protein Attributes:

Sequence length:

158

Sequence:

50:

100:

150:

158:

FRDRNEKL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000086708

String:

Q8VDS3

KEGG:

mmu:52609

UniGene:

Mm.323442

SMR:

Q8VDS3

Pfam:

PF00385

Uniprot:

Q8VDS3

FOR

ELISA Kit for Mouse Chromobox protein homolog 7

CLIA Kit for Mouse Chromobox protein homolog 7

Polyclonal Antibody for Mouse Chromobox protein homolog 7

Monoclonal Antibody for Mouse Chromobox protein homolog 7

Protein for Mouse Chromobox protein homolog 7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Polycomb CBX7 has a unifying role in cellular lifespan."
Gil J. , Bernard D. , Martinez D. , Beach D.
Nat. Cell Biol.6:67-72(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;INTERACTION WITH RING1
strain: CD-1.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Mammary tumor.
3.

"Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin."
Bernstein E. , Duncan E.M. , Masui O. , Gil J. , Heard E. , Allis C.D.
Mol. Cell. Biol.26:2560-2569(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF PHE-11 AND TRP-35
4.

"Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a."
Yap K.L. , Li S. , Munoz-Cabello A.M. , Raguz S. , Zeng L. , Mujtaba S. , Gil J. , Walsh M.J. , Zhou M.M.
Mol. Cell38:662-674(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-71 IN COMPLEX WITH HISTONE H3 DIMETHYLATED AT 'LYS-27';FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF ARG-17; LYS-31 AND TRP-35

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