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Index > Protein center > CCNDBP1(Gene name) > Human
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  • CCNDBP1 (Gene name),
  • Cyclin-D1-binding protein 1 (Protein name ),  CCDB1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CCNDBP1(DIP1;GCIP;HHM);
    Protein name:
    Cyclin-D1-binding protein 1;
    Alternative:
    Human homolog of Maid;Grap2 and cyclin-D-interacting protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.
    Function:
    May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    360
    Sequence:
    50:
    MASATAPAAA | VPTLASPLEQ | LRHLAEELRL | LLPRVRVGEA | QETTEEFNRE | 
    100:
    MFWRRLNEAA | VTVSREATTL | TIVFSQLPLP | SPQETQKFCE | QVHAAIKAFI | 
    150:
    AVYYLLPKDQ | GITLRKLVRG | ATLDIVDGMA | QLMEVLSVTP | TQSPENNDLI | 
    200:
    SYNSVWVACQ | QMPQIPRDNK | AAALLMLTKN | VDFVKDAHEE | MEQAVEECDP | 
    250:
    YSGLLNDTEE | NNSDNHNHED | DVLGFPSNQD | LYWSEDDQEL | IIPCLALVRA | 
    300:
    SKACLKKIRM | LVAENGKKDQ | VAQLDDIVDI | SDEISPSVDD | LALSIYPPMC | 
    350:
    HLTVRINSAK | LVSVLKKALE | ITKASHVTPQ | PEDSWIPLLI | NAIDHCMNRI | 
    360:
    KELTQSELEL | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cyclin-D1-binding protein 1
    ELISA Kit for Human Cyclin-D1-binding protein 1
    ELISA Kit for Human Cyclin-D1-binding protein 1
    ELISA Kit for Human Cyclin-D1-binding protein 1
    CLIA Kit for Human Cyclin-D1-binding protein 1
    CLIA Kit for Human Cyclin-D1-binding protein 1
    CLIA Kit for Human Cyclin-D1-binding protein 1
    CLIA Kit for Human Cyclin-D1-binding protein 1
    Polyclonal Antibody for Human Cyclin-D1-binding protein 1
    Polyclonal Antibody for Human Cyclin-D1-binding protein 1
    Polyclonal Antibody for Human Cyclin-D1-binding protein 1
    Polyclonal Antibody for Human Cyclin-D1-binding protein 1
    Monoclonal Antibody for Human Cyclin-D1-binding protein 1
    Monoclonal Antibody for Human Cyclin-D1-binding protein 1
    Monoclonal Antibody for Human Cyclin-D1-binding protein 1
    Monoclonal Antibody for Human Cyclin-D1-binding protein 1
    Protein for Human Cyclin-D1-binding protein 1
    Protein for Human Cyclin-D1-binding protein 1
    Protein for Human Cyclin-D1-binding protein 1
    Protein for Human Cyclin-D1-binding protein 1

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    Precision
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins."
      Yao Y. , Doki Y. , Jiang W. , Imoto M. , Venkatraj V.S. , Warburton D. , Santella R.M. , Lu B. , Yan L. , Sun X.-H. , Su T. , Luo J. , Weinstein I.B.
      Exp. Cell Res.257:22-32(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH CCND1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;PHOSPHORYLATION
    2. 2.
      "Human homologue of maid: a dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression."
      Terai S. , Aoki H. , Thorgeirsson S.S.
      Hepatology32:357-366(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH TCF3;TISSUE SPECIFICITY
      tissue: Liver.
    3. 3.
      "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity."
      Xia C. , Bao Z. , Tabassam F. , Ma W. , Qiu M. , Hua S. , Liu M.
      J. Biol. Chem.275:20942-20948(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH CCND1 AND GRAP2;TISSUE SPECIFICITY
      tissue: Liver.
    4. 4.
      "Cloning and characterization of a novel human cDNA homologous to murine Maid mRNA."
      Gao J. , Yu L. , Mao N.H. , Wan Y.Z. , Yang Y.M. , Zhao S.Y.
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Hypothalamus.
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
      tissue: Hair follicle dermal papilla.
      tissue: Lung.
      tissue: Retinoblastoma.
      tissue: Trachea.
    8. 8.
      "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T. , Ota T. , Nishikawa T. , Hayashi K. , Suzuki Y. , Yamamoto J. , Wakamatsu A. , Kimura K. , Sakamoto K. , Hatano N. , Kawai Y. , Ishii S. , Saito K. , Kojima S. , Sugiyama T. , Ono T. , Okano K. , Yoshikawa Y. , more...
      DNA Res.12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Placenta.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Pancreas.
    11. 11.
      "p29, a novel GCIP-interacting protein, localizes in the nucleus."
      Chang M.-S. , Chang C.-L. , Huang C.-J. , Yang Y.-C.
      Biochem. Biophys. Res. Commun.279:732-737(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYF2
    12. 12.
      "Human homologue of maid is a useful marker protein in hepatocarcinogenesis."
      Takami T. , Terai S. , Yokoyama Y. , Tanimoto H. , Tajima K. , Uchida K. , Yamasaki T. , Sakaida I. , Nishina H. , Thorgeirsson S.S. , Okita K.
      Gastroenterology128:1369-1380(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INTERACTION WITH COPS5
    13. 13.
      "GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis."
      Ma W. , Stafford L.J. , Li D. , Luo J. , Li X. , Ning G. , Liu M.
      J. Cell. Biochem.100:1376-1386(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIRT6;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION
    14. 14.
      "Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells."
      Chang T.-W. , Chen C.-C. , Chen K.-Y. , Su J.-H. , Chang J.-H. , Chang M.-C.
      Oncogene27:332-338(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RPLP0;SUBCELLULAR LOCATION
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
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