Protein name:
Voltage-dependent calcium channel gamma-4 subunit ;
Alternative:
Transmembrane AMPAR regulatory protein gamma-4 (TARP gamma-4) ;Neuronal voltage-gated calcium channel gamma-4 subunit ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8.
Function:
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MVRCDRGLQM | LLTTAGAFAA | FSLMAIAIGT | DYWLYSSAHI | CNGTNLTMDD |
100:
GPPPRRARGD | LTHSGLWRVC | CIEGIYKGHC | FRINHFPEDN | DYDHDSSEYL |
150:
LRIVRASSVF | PILSTILLLL | GGLCIGAGRI | YSRKNNIVLS | AGILFVAAGL |
200:
SNIIGIIVYI | SSNTGDPSDK | RDEDKKNHYN | YGWSFYFGAL | SFIVAETVGV |
250:
LAVNIYIEKN | KELRFKTKRE | FLKASSSSPY | ARMPSYRYRR | RRSRSSSRST |
300:
EASPSRDVSP | MGLKITGAIP | MGELSMYTLS | REPLKVTTAA | SYSPDQEASF |
327:
LQVHDFFQQD | LKEGFHVSML | NRRTTPV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
ELISA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
ELISA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
CLIA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
CLIA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
CLIA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
Polyclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
Polyclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
Polyclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
Monoclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
Monoclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
Monoclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
Protein for Human Voltage-dependent calcium channel gamma-4 subunit
Protein for Human Voltage-dependent calcium channel gamma-4 subunit
Protein for Human Voltage-dependent calcium channel gamma-4 subunit
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION