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Index > Protein center > CACNG4(Gene name) > Human
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  • CACNG4 (Gene name),
  • Voltage-dependent calcium channel gamma-4 subunit (Protein name ),  CCG4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CACNG4;
    Protein name:
    Voltage-dependent calcium channel gamma-4 subunit;
    Alternative:
    Transmembrane AMPAR regulatory protein gamma-4(TARP gamma-4);Neuronal voltage-gated calcium channel gamma-4 subunit;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8.
    Function:
    Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    327
    Sequence:
    50:
    MVRCDRGLQM | LLTTAGAFAA | FSLMAIAIGT | DYWLYSSAHI | CNGTNLTMDD | 
    100:
    GPPPRRARGD | LTHSGLWRVC | CIEGIYKGHC | FRINHFPEDN | DYDHDSSEYL | 
    150:
    LRIVRASSVF | PILSTILLLL | GGLCIGAGRI | YSRKNNIVLS | AGILFVAAGL | 
    200:
    SNIIGIIVYI | SSNTGDPSDK | RDEDKKNHYN | YGWSFYFGAL | SFIVAETVGV | 
    250:
    LAVNIYIEKN | KELRFKTKRE | FLKASSSSPY | ARMPSYRYRR | RRSRSSSRST | 
    300:
    EASPSRDVSP | MGLKITGAIP | MGELSMYTLS | REPLKVTTAA | SYSPDQEASF | 
    327:
    LQVHDFFQQD | LKEGFHVSML | NRRTTPV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
    ELISA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
    ELISA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
    CLIA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
    CLIA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
    CLIA Kit for Human Voltage-dependent calcium channel gamma-4 subunit
    Polyclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
    Polyclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
    Polyclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
    Monoclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
    Monoclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
    Monoclonal Antibody for Human Voltage-dependent calcium channel gamma-4 subunit
    Protein for Human Voltage-dependent calcium channel gamma-4 subunit
    Protein for Human Voltage-dependent calcium channel gamma-4 subunit
    Protein for Human Voltage-dependent calcium channel gamma-4 subunit

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    Precision
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    Linearity
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    References
    1. 1.
      "Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication."
      Burgess D.L. , Davis C.F. , Gefrides L.A. , Noebels J.L.
      Genome Res.9:1204-1213(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Identification of the Homo sapiens putative voltage-gated calcium channel gamma-4 subunit."
      Black J.L. III , Lennon V.A.
      Submitted (1999-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Caudate nucleus.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    6. 6.
      "Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
      Kato A.S. , Gill M.B. , Ho M.T. , Yu H. , Tu Y. , Siuda E.R. , Wang H. , Qian Y.W. , Nisenbaum E.S. , Tomita S. , Bredt D.S.
      Neuron68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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