Cd22 ELISA Kit for Mouse(Mus musculus) | EIAab.comCd22 ELISA Kit for Mouse(Mus musculus)

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Cd22 (Gene name),

B-cell receptor CD22 (Protein name ), CD22_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cd22(Lyb-8;Siglec2);

Protein name:

B-cell receptor CD22;

Alternative:

Sialic acid-binding Ig-like lectin 2(Siglec-2);B-lymphocyte cell adhesion molecule(BL-CAM);T-cell surface antigen Leu-14;

CD:

CD22;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with SYK, PIK3R1/PIK3R2, PLCG1, SHC1, INPP5D and GRB2 upon phosphorylation. May form a complex with INPP5D/SHIP, GRB2 and SHC1. Interacts with PTPN6/SHP-1 upon phosphorylation.

Function:

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

862

Sequence:

50:

100:

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450:

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650:

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850:

862:

AKEDVDYVTL | KH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.260994

Pfam:

PF08205

KEGG:

mmu:12483

String:

P35329

SMR:

P35329

Uniprot:

P35329

FOR

ELISA Kit for Mouse B-cell receptor CD22

Cat.:

E1513h

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Manual:

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Packing:

96T

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ELISA Kit for Mouse B-cell receptor CD22

Cat.:

E1513m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse B-cell receptor CD22

Cat.:

U1513m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse B-cell receptor CD22

Cat.:

U1513h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse B-cell receptor CD22

Cat.:

P1513Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse B-cell receptor CD22

Cat.:

P1513Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse B-cell receptor CD22

Protein for Mouse B-cell receptor CD22

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Organization of the murine Cd22 locus. Mapping to chromosome 7 and characterization of two alleles."
Law C.-L. , Torres R.M. , Sundberg H.A. , Parkhouse R.M. , Brannan C.I. , Copeland N.G. , Jenkins N.A. , Clark E.A.
J. Immunol.151:175-187(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
strain: DBA/2J.
tissue: Liver.
2.

"Polymorphisms in the Cd22 gene of inbred mouse strains."
Lajaunias F. , Ibnou-Zekri N. , Fossati Jimack L. , Chicheportiche Y. , Parkhouse R.M. , Mary C. , Reininger L. , Brighouse G. , Izui S.
Immunogenetics49:991-995(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BXSB.
strain: C57BL/6.
strain: MRL.
3.

"Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22alpha lupus-prone mice."
Mary C. , Laporte C. , Parzy D. , Santiago M.L. , Stefani F. , Lajaunias F. , Parkhouse M.E. , O'Keefe T.L. , Neuberger M.S. , Izui S. , Reininger L.
J. Immunol.165:2987-2996(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-178 (ISOFORMS 1; 2 AND 3)
strain: NZW.
tissue: Spleen.
4.

"Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily."
Kelm S. , Pelz A. , Schauer R. , Filbin M.T. , Tang S. , de Bellard M.E. , Schnaar R.L. , Mahoney J.A. , Hartnell A. , Bradfield P. , Crocker P.R.
Curr. Biol.4:965-972(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIALIC ACID-BINDING
5.

"Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes."
Chan V.W. , Lowell C.A. , DeFranco A.L.
Curr. Biol.8:545-553(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY LYN
6.

"Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22."
Yohannan J. , Wienands J. , Coggeshall K.M. , Justement L.B.
J. Biol. Chem.274:18769-18776(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2; SYK; PIK3R1/PIK3R2 AND PLCG1;PHOSPHORYLATION AT TYR-777; TYR-822; TYR-837 AND TYR-857;MUTAGENESIS OF TYR-822
7.

"CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux."
Poe J.C. , Fujimoto M. , Jansen P.J. , Miller A.S. , Tedder T.F.
J. Biol. Chem.275:17420-17427(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2; SHC1 AND INPP5D;PHOSPHORYLATION BY LYN

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