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Index > Protein center > Cd244(Gene name) > Mouse
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  • Cd244 (Gene name),
  • Natural killer cell receptor 2B4 (Protein name ),  CD244_MOUSE from NCBI database.
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  • Gene name:
    Cd244(2b4;Nmrk);
    Protein name:
    Natural killer cell receptor 2B4;
    Alternative:
    Non-MHC restricted killing associated;NK cell type I receptor protein 2B4(NKR2B4);Signaling lymphocytic activation molecule 4;SLAM family member 4(SLAMF4);
    CD:
    CD244;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2.
    Function:
    Modulate other receptor-ligand interactions to enhance leukocyte activation.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    397
    Sequence:
    50:
    MLGQAVLFTT | FLLLRAHQGQ | DCPDSSEEVV | GVSGKPVQLR | PSNIQTKDVS | 
    100:
    VQWKKTEQGS | HRKIEILNWY | NDGPSWSNVS | FSDIYGFDYG | DFALSIKSAK | 
    150:
    LQDSGHYLLE | ITNTGGKVCN | KNFQLLILDH | VETPNLKAQW | KPWTNGTCQL | 
    200:
    FLSCLVTKDD | NVSYALYRGS | TLISNQRNST | HWENQIDASS | LHTYTCNVSN | 
    250:
    RASWANHTLN | FTHGCQSVPS | NFRFLPFGVI | IVILVTLFLG | AIICFCVWTK | 
    300:
    KRKQLQFSPK | EPLTIYEYVK | DSRASRDQQG | CSRASGSPSA | VQEDGRGQRE | 
    350:
    LDRRVSEVLE | QLPQQTFPGD | RGTMYSMIQC | KPSDSTSQEK | CTVYSVVQPS | 
    397:
    RKSGSKKRNQ | NSSLSCTVYE | EVGNPWLKAH | NPARLSRREL | ENFDVYS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Natural killer cell receptor 2B4
    Cat.:
    E9362h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Natural killer cell receptor 2B4
    Cat.:
    E9362r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Natural killer cell receptor 2B4
    Cat.:
    E9362m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Natural killer cell receptor 2B4
    Cat.:
    U9362m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Natural killer cell receptor 2B4
    Cat.:
    U9362h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Natural killer cell receptor 2B4
    Cat.:
    U9362r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Natural killer cell receptor 2B4
    Cat.:
    P9362Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Natural killer cell receptor 2B4
    Cat.:
    P9362Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Natural killer cell receptor 2B4
    Cat.:
    P9362Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Natural killer cell receptor 2B4
    Monoclonal Antibody for Mouse Natural killer cell receptor 2B4
    Monoclonal Antibody for Mouse Natural killer cell receptor 2B4
    Protein for Mouse Natural killer cell receptor 2B4
    Protein for Mouse Natural killer cell receptor 2B4
    Protein for Mouse Natural killer cell receptor 2B4

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    References
    1. 1.
      "Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells."
      Mathew P.A. , Garni-Wagner B.A. , Land K. , Takashima A. , Stoneman E. , Bennett M. , Kumar V.
      J. Immunol.151:5328-5337(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: C57BL/6.
    2. 2.
      "Polymorphism in the 2B4 gene of inbred mouse strains."
      Kumaresan P.R. , Huynh V.T. , Mathew P.A.
      Immunogenetics51:758-761(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: A.CA.
    3. 3.
      "Characterization of genomic structure and alternative splicing of the murine NK cell receptor 2B4."
      Stepp S.E. , Schatzle J.D. , Bennett M. , Kumar V. , Mathew P.A.
      Submitted (1998-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: C57BL/6.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Bone.
    5. 5.
      "NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition."
      Ames J.B. , Vyas V. , Lusin J.D. , Mariuzza R.
      Biochemistry44:6416-6423(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 21-129;DISULFIDE BOND
    6. 6.
      "Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family."
      Velikovsky C.A. , Deng L. , Chlewicki L.K. , Fernandez M.M. , Kumar V. , Mariuzza R.A.
      Immunity27:572-584(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 19-129 ALONE AND IN COMPLEX WITH CD48;DISULFIDE BOND
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