Cd2ap ELISA Kit for Mouse(Mus musculus) | EIAab.comCd2ap ELISA Kit for Mouse(Mus musculus)

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Cd2ap (Gene name),

CD2-associated protein (Protein name ), CD2AP_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cd2ap(Mets1);

Protein name:

CD2-associated protein;

Alternative:

Mesenchyme-to-epithelium transition protein with SH3 domains 1(METS-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Self-associates. Homodimer (Potential). Interacts (via SH3 2 domain) with CBL (via phosphorylated C-terminus). Interacts with BCAR1/p130Cas (via SH3 domain). Interacts with F-actin, PKD2, NPHS1 and NPHS2. Interacts with WTIP. Interacts with FAM125A and ARHGAP17. Interacts with ANLN, CD2 and CBLB. Interacts with PDCD6IP and TSG101 (By similarity). Interacts with DDN; interaction is direct.

Function:

Required for cytokinesis (By similarity). Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus.

Subcellular Location:

Cytoplasm cytoskeleton Cell projection ruffle During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase (By similarity). Located at podocyte slit diaphragm between podocyte foot processes.

Protein Attributes:

Sequence length:

637

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

637:

DHGKELEKLR | KELEEEKAMR | SNLEVEIAKL | KKAVLLS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:12488

UniGene:

Mm.218637

SMR:

Q9JLQ0

STRING:

10090.ENSMUSP00000024709

Pfam:

PF00018

String:

Q9JLQ0

Uniprot:

Q9JLQ0

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ELISA Kit for Mouse CD2-associated protein

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E2545r

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96T

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ELISA Kit for Mouse CD2-associated protein

Cat.:

E2545h

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96T

ELISA Kit for Mouse CD2-associated protein

Cat.:

E2545m

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96T

CLIA Kit for Mouse CD2-associated protein

Cat.:

U2545h

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96T

CLIA Kit for Mouse CD2-associated protein

Cat.:

U2545r

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Packing:

96T

CLIA Kit for Mouse CD2-associated protein

Cat.:

U2545m

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96T

Polyclonal Antibody for Mouse CD2-associated protein

Cat.:

P2545Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse CD2-associated protein

Cat.:

P2545Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse CD2-associated protein

Cat.:

P2545Rb-m

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40ug/0.2ml

Monoclonal Antibody for Mouse CD2-associated protein

Protein for Mouse CD2-associated protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts."
Dustin M.L. , Olszowy M.W. , Holdorf A.D. , Li J. , Bromley S. , Desai N. , Widder P. , Rosenberger F. , van der Merwe P.A. , Allen P.M. , Shaw A.S.
Cell94:667-677(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH CD2
2.

"In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2."
Lehtonen S. , Ora A. , Olkkonen V.M. , Geng L. , Zerial M. , Somlo S. , Lehtonen E.
J. Biol. Chem.275:32888-32893(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH PKD2
3.

"Role of the interaction between CD2AP and c-Cbl."
Meton I. , Le Marchand-Brustel Y. , Cormont M.
Submitted (2002-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 394-637
tissue: Mammary tumor.
6.

"Congenital nephrotic syndrome in mice lacking CD2-associated protein."
Shih N.Y. , Li J. , Karpitskii V. , Nguyen A. , Dustin M.L. , Kanagawa O. , Miner J.H. , Shaw A.S.
Science286:312-315(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH NPHS1;DISRUPTION PHENOTYPE
7.

"CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain."
Shih N.Y. , Li J. , Cotran R. , Mundel P. , Miner J.H. , Shaw A.S.
Am. J. Pathol.159:2303-2308(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH NPHS1
8.

"Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin."
Schwarz K. , Simons M. , Reiser J. , Saleem M.A. , Faul C. , Kriz W. , Shaw A.S. , Holzman L.B. , Mundel P.
J. Clin. Invest.108:1621-1629(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NPHS1 AND NPHS2
9.

"CD2-associated protein directly interacts with the actin cytoskeleton."
Lehtonen S. , Zhao F. , Lehtonen E.
Am. J. Physiol.283:F734-F743(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH F-ACTIN
10.

"A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus."
Srichai M.B. , Konieczkowski M. , Padiyar A. , Konieczkowski D.J. , Mukherjee A. , Hayden P.S. , Kamat S. , El-Meanawy M.A. , Khan S. , Mundel P. , Lee S.B. , Bruggeman L.A. , Schelling J.R. , Sedor J.R.
J. Biol. Chem.279:14398-14408(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WTIP
11.

"Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes."
Asanuma K. , Campbell K.N. , Kim K. , Faul C. , Mundel P.
Proc. Natl. Acad. Sci. U.S.A.104:10134-10139(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDN
12.

"CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction."
Tsui C.C. , Pierchala B.A.
J. Neurosci.28:8789-8800(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RET;TISSUE SPECIFICITY
13.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"The high resolution NMR structure of the third SH3 domain of CD2AP."
Ortega Roldan J.L. , Romero Romero M.L. , Ora A. , Ab E. , Lopez Mayorga O. , Azuaga A.I. , van Nuland N.A.
J. Biomol. NMR39:331-336(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 270-329

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