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Index > Protein center > Cd2ap(Gene name) > Rat
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  • Cd2ap (Gene name),
  • CD2-associated protein (Protein name ),  CD2AP_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Cd2ap;
    Protein name:
    CD2-associated protein;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Self-associates. Homodimer (Potential). Interacts with F-actin, PKD2, NPHS1 and NPHS2. Interacts with WTIP. Interacts with DDN; interaction is direct. Interacts (via SH3 2 domain) with CBL (via phosphorylated C-terminus). Interacts with BCAR1/p130Cas (via SH3 domain). Interacts with MVB12A and ARHGAP17. Interacts with ANLN, CD2 and CBLB. Interacts with PDCD6IP and TSG101. Interacts with RIN3. Interacts directly with RET (inactive) and CBLC; upon RET activation by GDNF suggested to dissociate from RET as CBLC:CD2AP complex.
    Function:
    Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.
    Subcellular Location:
    Cytoplasm Cytoskeleton Cell projection Ruffle Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase.
    Protein Attributes:
    Sequence length:
    637
    Sequence:
    50:
    MVDYIVEYDY | DAVHDDELTI | RVGEIIRNVK | KLQEEGWLEG | ELNGRRGMFP | 
    100:
    DNFVKEIKRE | TEPKDDNLPI | KRERPGNVAS | LVQRISTYGL | PAGGIQPHPQ | 
    150:
    TKAMKKKTKK | RQCKVLFEYS | PQNEDELELT | VGDVIDVIEE | VEEGWWSGTL | 
    200:
    NNKLGLFPSN | FVKELESTDD | GEMHDAQEES | EVSLTGPTSP | MPSPGNGSEP | 
    250:
    APGSVTQPKK | IRGVGFGDIF | KEGSVKLRTR | TSSSETEEKK | SEKPLILQSL | 
    300:
    GSRTQNVEVT | KPDIDGKIKA | KEYCKTVFPY | TGTNEDELTF | REGEIIHLIS | 
    350:
    KETGEAGWWK | GELNGKEGVF | PDNFAVQISE | LDKDFPKPKK | PPPPAKGPAP | 
    400:
    KPDPLAGEKK | TFPLKAEDRD | EKSLLEQKPS | KPAAPQVPPK | KPTPPTKANN | 
    450:
    LLRSPGTMYP | KRPEKPVPPP | PPTAKINGEV | STISSKIDTE | PLSKPKLDPE | 
    500:
    QLPVRPKSVD | LDALVARNSK | ETDNVNFDDI | ASSENLLHLT | ANRPKMPGRR | 
    550:
    LPGRFNGGHS | PTQSPEKTLK | LPKDDDSGNI | KPSEFKKDAG | YSSKPSLSAP | 
    600:
    SSASKVNTAA | FLSPLELKAK | VEADDGKKSS | LDELRAQIIE | LLCIVDALKK | 
    637:
    DHGKELEKLR | RELEEEKAMR | SNLEVEIAKL | KKAVLLS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat CD2-associated protein
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    E2545r
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    96T
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    ELISA Kit for Rat CD2-associated protein
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    E2545h
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    Packing:
    96T
    ELISA Kit for Rat CD2-associated protein
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    E2545m
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    96T
    CLIA Kit for Rat CD2-associated protein
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    U2545h
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    Packing:
    96T
    CLIA Kit for Rat CD2-associated protein
    Cat.:
    U2545r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat CD2-associated protein
    Cat.:
    U2545m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Rat CD2-associated protein
    Cat.:
    P2545Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat CD2-associated protein
    Cat.:
    P2545Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat CD2-associated protein
    Cat.:
    P2545Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat CD2-associated protein
    Monoclonal Antibody for Rat CD2-associated protein
    Monoclonal Antibody for Rat CD2-associated protein
    Protein for Rat CD2-associated protein
    Protein for Rat CD2-associated protein
    Protein for Rat CD2-associated protein

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    References
    1. 1.
      "Rat CD2AP."
      Kawachi H. , Koike H. , Shimizu F.
      Submitted (2002-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    3. 3.
      "CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction."
      Tsui C.C. , Pierchala B.A.
      J. Neurosci.28:8789-8800(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RET STABILITY;INTERACTION WITH CBLC AND RET;TISSUE SPECIFICITY
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