Protein name:
CD2-associated protein ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Self-associates. Homodimer (Potential). Interacts with F-actin, PKD2, NPHS1 and NPHS2. Interacts with WTIP. Interacts with DDN; interaction is direct. Interacts (via SH3 2 domain) with CBL (via phosphorylated C-terminus). Interacts with BCAR1/p130Cas (via SH3 domain). Interacts with MVB12A and ARHGAP17. Interacts with ANLN, CD2 and CBLB. Interacts with PDCD6IP and TSG101. Interacts with RIN3. Interacts directly with RET (inactive) and CBLC; upon RET activation by GDNF suggested to dissociate from RET as CBLC:CD2AP complex.
Function:
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.
Subcellular Location:
Cytoplasm
Cytoskeleton
Cell projection
Ruffle
Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase.
Protein Attributes:
50:
MVDYIVEYDY | DAVHDDELTI | RVGEIIRNVK | KLQEEGWLEG | ELNGRRGMFP |
100:
DNFVKEIKRE | TEPKDDNLPI | KRERPGNVAS | LVQRISTYGL | PAGGIQPHPQ |
150:
TKAMKKKTKK | RQCKVLFEYS | PQNEDELELT | VGDVIDVIEE | VEEGWWSGTL |
200:
NNKLGLFPSN | FVKELESTDD | GEMHDAQEES | EVSLTGPTSP | MPSPGNGSEP |
250:
APGSVTQPKK | IRGVGFGDIF | KEGSVKLRTR | TSSSETEEKK | SEKPLILQSL |
300:
GSRTQNVEVT | KPDIDGKIKA | KEYCKTVFPY | TGTNEDELTF | REGEIIHLIS |
350:
KETGEAGWWK | GELNGKEGVF | PDNFAVQISE | LDKDFPKPKK | PPPPAKGPAP |
400:
KPDPLAGEKK | TFPLKAEDRD | EKSLLEQKPS | KPAAPQVPPK | KPTPPTKANN |
450:
LLRSPGTMYP | KRPEKPVPPP | PPTAKINGEV | STISSKIDTE | PLSKPKLDPE |
500:
QLPVRPKSVD | LDALVARNSK | ETDNVNFDDI | ASSENLLHLT | ANRPKMPGRR |
550:
LPGRFNGGHS | PTQSPEKTLK | LPKDDDSGNI | KPSEFKKDAG | YSSKPSLSAP |
600:
SSASKVNTAA | FLSPLELKAK | VEADDGKKSS | LDELRAQIIE | LLCIVDALKK |
637:
DHGKELEKLR | RELEEEKAMR | SNLEVEIAKL | KKAVLLS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Rat CD2-associated protein
ELISA Kit for Rat CD2-associated protein
ELISA Kit for Rat CD2-associated protein
CLIA Kit for Rat CD2-associated protein
CLIA Kit for Rat CD2-associated protein
CLIA Kit for Rat CD2-associated protein
Polyclonal Antibody for Rat CD2-associated protein
Polyclonal Antibody for Rat CD2-associated protein
Polyclonal Antibody for Rat CD2-associated protein
Monoclonal Antibody for Rat CD2-associated protein
Monoclonal Antibody for Rat CD2-associated protein
Monoclonal Antibody for Rat CD2-associated protein
Protein for Rat CD2-associated protein
Protein for Rat CD2-associated protein
Protein for Rat CD2-associated protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A.
,
Weinstock G.M.
,
Metzker M.L.
,
Muzny D.M.
,
Sodergren E.J.
,
Scherer S.
,
Scott G.
,
Steffen D.
,
Worley K.C.
,
Burch P.E.
,
Okwuonu G.
,
Hines S.
,
Lewis L.
,
Deramo C.
,
Delgado O.
,
Dugan-Rocha S.
,
Miner G.
,
Morgan M.
,
Hawes A.
,
Gill R.
,
Holt R.A.
,
Adams M.D.
,
Amanatides P.G.
,
Baden-Tillson H.
,
Barnstead M.
,
Chin S.
,
Evans C.A.
,
Ferriera S.
,
Fosler C.
,
Glodek A.
,
Gu Z.
,
Jennings D.
,
Kraft C.L.
,
Nguyen T.
,
Pfannkoch C.M.
,
Sitter C.
,
Sutton G.G.
,
Venter J.C.
,
Woodage T.
,
Smith D.
,
Lee H.-M.
,
Gustafson E.
,
Cahill P.
,
Kana A.
,
Doucette-Stamm L.
,
Weinstock K.
,
Fechtel K.
,
Weiss R.B.
,
Dunn D.M.
,
Green E.D.
,
Blakesley R.W.
,
Bouffard G.G.
,
De Jong P.J.
,
Osoegawa K.
,
Zhu B.
,
Marra M.
,
Schein J.
,
Bosdet I.
,
Fjell C.
,
Jones S.
,
Krzywinski M.
,
Mathewson C.
,
Siddiqui A.
,
Wye N.
,
McPherson J.
,
Zhao S.
,
Fraser C.M.
,
Shetty J.
,
Shatsman S.
,
Geer K.
,
Chen Y.
,
Abramzon S.
,
Nierman W.C.
,
Havlak P.H.
,
Chen R.
,
Durbin K.J.
,
Egan A.
,
Ren Y.
,
Song X.-Z.
,
Li B.
,
Liu Y.
,
Qin X.
,
Cawley S.
,
Cooney A.J.
,
D'Souza L.M.
,
Martin K.
,
Wu J.Q.
,
Gonzalez-Garay M.L.
,
Jackson A.R.
,
Kalafus K.J.
,
McLeod M.P.
,
Milosavljevic A.
,
Virk D.
,
Volkov A.
,
Wheeler D.A.
,
Zhang Z.
,
Bailey J.A.
,
Eichler E.E.
,
Tuzun E.
,
Birney E.
,
Mongin E.
,
Ureta-Vidal A.
,
Woodwark C.
,
Zdobnov E.
,
Bork P.
,
Suyama M.
,
Torrents D.
,
Alexandersson M.
,
Trask B.J.
,
Young J.M.
,
Huang H.
,
Wang H.
,
Xing H.
,
Daniels S.
,
Gietzen D.
,
Schmidt J.
,
Stevens K.
,
Vitt U.
,
Wingrove J.
,
Camara F.
,
Mar Alba M.
,
Abril J.F.
,
Guigo R.
,
Smit A.
,
Dubchak I.
,
Rubin E.M.
,
Couronne O.
,
Poliakov A.
,
Huebner N.
,
Ganten D.
,
Goesele C.
,
Hummel O.
,
Kreitler T.
,
Lee Y.-A.
,
Monti J.
,
Schulz H.
,
Zimdahl H.
,
Himmelbauer H.
,
Lehrach H.
,
Jacob H.J.
,
Bromberg S.
,
Gullings-Handley J.
,
Jensen-Seaman M.I.
,
Kwitek A.E.
,
Lazar J.
,
Pasko D.
,
Tonellato P.J.
,
Twigger S.
,
Ponting C.P.
,
Duarte J.M.
,
Rice S.
,
Goodstadt L.
,
Beatson S.A.
,
Emes R.D.
,
Winter E.E.
,
Webber C.
,
Brandt P.
,
Nyakatura G.
,
Adetobi M.
,
Chiaromonte F.
,
Elnitski L.
,
Eswara P.
,
Hardison R.C.
,
Hou M.
,
Kolbe D.
,
Makova K.
,
Miller W.
,
Nekrutenko A.
,
Riemer C.
,
Schwartz S.
,
Taylor J.
,
Yang S.
,
Zhang Y.
,
Lindpaintner K.
,
Andrews T.D.
,
Caccamo M.
,
Clamp M.
,
Clarke L.
,
Curwen V.
,
Durbin R.M.
,
Eyras E.
,
Searle S.M.
,
Cooper G.M.
,
Batzoglou S.
,
Brudno M.
,
Sidow A.
,
Stone E.A.
,
Payseur B.A.
,
Bourque G.
,
Lopez-Otin C.
,
Puente X.S.
,
Chakrabarti K.
,
Chatterji S.
,
Dewey C.
,
Pachter L.
,
Bray N.
,
Yap V.B.
,
Caspi A.
,
Tesler G.
,
Pevzner P.A.
,
Haussler D.
,
Roskin K.M.
,
Baertsch R.
,
Clawson H.
,
Furey T.S.
,
Hinrichs A.S.
,
Karolchik D.
,
Kent W.J.
,
Rosenbloom K.R.
,
Trumbower H.
,
Weirauch M.
,
Cooper D.N.
,
Stenson P.D.
,
Ma B.
,
Brent M.
,
Arumugam M.
,
Shteynberg D.
,
Copley R.R.
,
Taylor M.S.
,
Riethman H.
,
Mudunuri U.
,
Peterson J.
,
Guyer M.
,
Felsenfeld A.
,
Old S.
,
Mockrin S.
,
Collins F.S.
more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN RET STABILITY;INTERACTION WITH CBLC AND RET;TISSUE SPECIFICITY