CD47 ELISA Kit for Human(Homo sapiens) | EIAab.comCD47 ELISA Kit for Human(Homo sapiens)

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CD47 (Gene name),

Leukocyte surface antigen CD47 (Protein name ), CD47_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CD47(MER6);

Protein name:

Leukocyte surface antigen CD47;

Alternative:

Integrin-associated protein(IAP);Antigenic surface determinant protein OA3;Protein MER6;

CD:

CD47;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.

Function:

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

323

Sequence:

50:

100:

150:

200:

250:

300:

323:

PPRKAVEEPL | NAFKESKGMM | NDE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:961

UniGene:

Hs.446414

Pfam:

PF04549

STRING:

9606.ENSP00000355361

String:

Q08722

MIM:

601028

SMR:

Q08722

Uniprot:

Q08722

FOR

ELISA Kit for Human Leukocyte surface antigen CD47

Cat.:

E15360p

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96T

ELISA Kit for Human Leukocyte surface antigen CD47

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E15360m

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96T

ELISA Kit for Human Leukocyte surface antigen CD47

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E15360b

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96T

ELISA Kit for Human Leukocyte surface antigen CD47

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E15360h

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96T

ELISA Kit for Human Leukocyte surface antigen CD47

Cat.:

E15360r

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96T

CLIA Kit for Human Leukocyte surface antigen CD47

Cat.:

U15360p

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96T

CLIA Kit for Human Leukocyte surface antigen CD47

Cat.:

U15360b

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96T

CLIA Kit for Human Leukocyte surface antigen CD47

Cat.:

U15360m

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Packing:

96T

CLIA Kit for Human Leukocyte surface antigen CD47

Cat.:

U15360r

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96T

CLIA Kit for Human Leukocyte surface antigen CD47

Cat.:

U15360h

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96T

Polyclonal Antibody for Human Leukocyte surface antigen CD47

Cat.:

P15360Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Leukocyte surface antigen CD47

Cat.:

P15360Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Leukocyte surface antigen CD47

Cat.:

P15360Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Leukocyte surface antigen CD47

Protein for Human Leukocyte surface antigen CD47

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains."
Campbell I.G. , Freemont P.S. , Foulkes W. , Trowsdale J.
Cancer Res.52:5416-5420(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OA3-323)
tissue: Ovary.
2.

"Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding."
Lindberg F.P. , Gresham H.D. , Schwarz E. , Brown E.J.
J. Cell Biol.123:485-496(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM OA3-305);FUNCTION;SUBCELLULAR LOCATION;TOPOLOGY
tissue: Myelomonocyte.
3.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-305)
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-323)
tissue: Brain.
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM OA3-305)
tissue: Hippocampus.
tissue: Leiomyosarcoma.
tissue: Ovarian adenocarcinoma.
7.

"Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3."
Mawby W.J. , Holmes C.H. , Anstee D.J. , Spring F.A. , Tanner M.J.A.
Biochem. J.304:525-530(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;IDENTIFICATION AS CD47
tissue: Erythrocyte.
8.

"Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane."
Wu A.-L. , Wang J. , Zheleznyak A. , Brown E.J.
Mol. Cell4:619-625(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBQLN1 AND UBQLN2
9.

"Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains."
Rebres R.A. , Vaz L.E. , Green J.M. , Brown E.J.
J. Biol. Chem.276:34607-34616(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BOND
10.

"Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation."
Latour S. , Tanaka H. , Demeure C. , Mateo V. , Rubio M. , Brown E.J. , Maliszewski C. , Lindberg F.P. , Oldenborg A. , Ullrich A. , Delespesse G. , Sarfati M.
J. Immunol.167:2547-2554(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SIRPA
11.

"An unappreciated role for RNA surveillance."
Hillman R.T. , Green R.E. , Brenner S.E.
Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
12.

"Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation."
Piccio L. , Vermi W. , Boles K.S. , Fuchs A. , Strader C.A. , Facchetti F. , Cella M. , Colonna M.
Blood105:2421-2427(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SIRPG
tissue: T-cell.
13.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-73 AND ASN-111
tissue: Liver.
14.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-50 AND ASN-73
tissue: Leukemic T-cell.
15.

"Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47."
Hatherley D. , Graham S.C. , Turner J. , Harlos K. , Stuart D.I. , Barclay A.N.
Mol. Cell31:266-277(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 19-136 IN COMPLEX WITH SIRPA;DISULFIDE BOND;GLYCOSYLATION AT ASN-23; ASN-50; ASN-73 AND ASN-111;PYROGLUTAMATE FORMATION AT GLN-19

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