Cell division control protein 42 homolog (Protein name
), CDC42_CANFA from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
CDC42;
Protein name:
Cell division control protein 42 homolog;
Alternative:
G25K GTP-binding protein;
Organism:
Dog (Canis familiarisCanis lupus familiaris).
General Annotation
Sub Unit:
Interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B and PARD6G (in a GTP-dependent manner). Interacts with activated CSPG4 and with BAIAP2. Interacts with Zizimin1/DOCK9 and Zizimin2/DOCK11, which activate it by exchanging GDP for GTP. Interacts with NET1 and ARHGAP33/TCGAP. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. The GTP-bound form interacts with CCPG1 (By similarity). Interacts with USP6 (By similarity). Interacts with NEK6.
Function:
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia.
Subcellular Location:
Cell membrane
Lipid-anchor
Cytoplasmic side
Cytoplasm
cytoskeleton
centrosome
Co-localizes with NEK6 in the centrosome.
Monoclonal Antibody for Dog Cell division control protein 42 homolog
Monoclonal Antibody for Dog Cell division control protein 42 homolog
Monoclonal Antibody for Dog Cell division control protein 42 homolog
Monoclonal Antibody for Dog Cell division control protein 42 homolog
Monoclonal Antibody for Dog Cell division control protein 42 homolog
Monoclonal Antibody for Dog Cell division control protein 42 homolog
Monoclonal Antibody for Dog Cell division control protein 42 homolog
Protein for Dog Cell division control protein 42 homolog
Protein for Dog Cell division control protein 42 homolog
Protein for Dog Cell division control protein 42 homolog
Protein for Dog Cell division control protein 42 homolog
Protein for Dog Cell division control protein 42 homolog
Protein for Dog Cell division control protein 42 homolog
Protein for Dog Cell division control protein 42 homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components induced by the Rho GTPase CDC42Hs." Dutartre H.
,
Davoust J.
,
Gorvel J.
,
Chavrier P.
Submitted (1995-06) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)