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Index > Protein center > CDCA2(Gene name) > Human
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  • CDCA2 (Gene name),
  • Cell division cycle-associated protein 2 (Protein name ),  CDCA2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CDCA2;
    Protein name:
    Cell division cycle-associated protein 2;
    Alternative:
    Recruits PP1 onto mitotic chromatin at anaphase protein(Repo-Man);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PPP1CC.
    Function:
    Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
    Subcellular Location:
    Nucleus Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
    Protein Attributes:
    Sequence length:
    1023
    Sequence:
    50:
    MDANSKDKPP | ETKESAMNNA | GNASFILGTG | KIVTPQKHAE | LPPNPCTPDT | 
    100:
    FKSPLNFSTV | TVEQLGITPE | SFVRNSAGKS | SSYLKKCRRR | SAVGARGSPE | 
    150:
    TNHLIRFIAR | QQNIKNARKS | PLAQDSPSQG | SPALYRNVNT | LRERISAFQS | 
    200:
    AFHSIKENEK | MTGCLEFSEA | GKESEMTDLT | RKEGLSACQQ | SGFPAVLSSK | 
    250:
    RRRISYQRDS | DENLTDAEGK | VIGLQIFNID | TDRACAVETS | VDLSEISSKL | 
    300:
    GSTQSGFLVE | ESLPLSELTE | TSNALKVADC | VVGKGSSDAV | SPDTFTAEVS | 
    350:
    SDAVPDVRSP | ATPACRRDLP | TPKTFVLRSV | LKKPSVKMCL | ESLQEHCNNL | 
    400:
    YDDDGTHPSL | ISNLPNCCKE | KEAEDEENFE | APAFLNMRKR | KRVTFGEDLS | 
    450:
    PEVFDESLPA | NTPLRKGGTP | VCKKDFSGLS | SLLLEQSPVP | EPLPQPDFDD | 
    500:
    KGENLENIEP | LQVSFAVLSS | PNKSSISETL | SGTDTFSSSN | NHEKISSPKV | 
    550:
    GRITRTSNRR | NQLVSVVEES | VCNLLNTEVQ | PCKEKKINRR | KSQETKCTKR | 
    600:
    ALPKKSQVLK | SCRKKKGKGK | KSVQKSLYGE | RDIASKKPLL | SPIPELPEVP | 
    650:
    EMTPSIPSIR | RLGSGYFSSN | GKLEEVKTPK | NPVKRKDLLR | HDPDLHMHQG | 
    700:
    YDKYDVSEFC | SYIKSSSSLG | NATSDEDPNT | NIMNINENKN | IPKAKNKSES | 
    750:
    ENEPKAGTDS | PVSCASVTEE | RVASDSPKPA | LTLQQGQEFS | AGGQNAENLC | 
    800:
    QFFKISPDLN | IKCERKDDFL | GAAEGKLQCN | RLMPNSQKDC | HCLGDVLIEN | 
    850:
    TKESKSQSED | LGRKPMESSS | VVSCRDRKDR | RRSMCYSDGR | SLHLEKNGNH | 
    900:
    TPSSSVGSSV | EISLENSELF | KDLSDAIEQT | FQRRNSETKV | RRSTRLQKDL | 
    950:
    ENEGLVWISL | PLPSTSQKAK | RRTICTFDSS | GFESMSPIKE | TVSSRQKPQM | 
    1000:
    APPVSDPENS | QGPAAGSSDE | PGKRRKSFCI | STLANTKATS | QFKGYRRRSS | 
    1023:
    LNGKGESSLT | ALERIEHNGE | RKQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cell division cycle-associated protein 2
    ELISA Kit for Human Cell division cycle-associated protein 2
    ELISA Kit for Human Cell division cycle-associated protein 2
    CLIA Kit for Human Cell division cycle-associated protein 2
    CLIA Kit for Human Cell division cycle-associated protein 2
    CLIA Kit for Human Cell division cycle-associated protein 2
    Polyclonal Antibody for Human Cell division cycle-associated protein 2
    Polyclonal Antibody for Human Cell division cycle-associated protein 2
    Polyclonal Antibody for Human Cell division cycle-associated protein 2
    Monoclonal Antibody for Human Cell division cycle-associated protein 2
    Monoclonal Antibody for Human Cell division cycle-associated protein 2
    Monoclonal Antibody for Human Cell division cycle-associated protein 2
    Protein for Human Cell division cycle-associated protein 2
    Protein for Human Cell division cycle-associated protein 2
    Protein for Human Cell division cycle-associated protein 2

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    Precision
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ILE-717
      tissue: Endometrial tumor.
      tissue: Melanoma.
    2. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-1023 (ISOFORM 1);VARIANTS ILE-717 AND SER-884
      tissue: Chondrosarcoma.
      tissue: Skin.
      tissue: Testis.
    3. 4.
      "Drug target discovery by gene expression analysis: cell cycle genes."
      Walker M.G.
      Curr. Cancer Drug Targets1:73-83(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 559-1023 (ISOFORM 1);VARIANT ILE-717
    4. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 561-1023 (ISOFORM 1)
      tissue: Testis.
    5. 6.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    6. 7.
      "Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability."
      Trinkle-Mulcahy L. , Andersen J. , Lam Y.W. , Moorhead G. , Mann M. , Lamond A.I.
      J. Cell Biol.172:679-692(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH PPP1CC;MUTAGENESIS OF 393-VAL--PHE-395
    7. 8.
      "Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis."
      Vagnarelli P. , Hudson D.F. , Ribeiro S.A. , Trinkle-Mulcahy L. , Spence J.M. , Lai F. , Farr C.J. , Lamond A.I. , Earnshaw W.C.
      Nat. Cell Biol.8:1133-1142(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-126; SER-131; SER-291; SER-309; THR-312; SER-400; SER-407; THR-412; SER-591 AND SER-756;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 10.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400 AND THR-412;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-400; SER-437 AND SER-591;VARIANT [LARGE SCALE ANALYSIS] ILE-717;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 12.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-936 AND SER-977;VARIANT [LARGE SCALE ANALYSIS] ILE-717;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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