Protein name:
Cell division cycle-associated protein 2 ;
Alternative:
Recruits PP1 onto mitotic chromatin at anaphase protein (Repo-Man) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with PPP1CC.
Function:
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
Subcellular Location:
Nucleus
Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
Protein Attributes:
50:
MDANSKDKPP | ETKESAMNNA | GNASFILGTG | KIVTPQKHAE | LPPNPCTPDT |
100:
FKSPLNFSTV | TVEQLGITPE | SFVRNSAGKS | SSYLKKCRRR | SAVGARGSPE |
150:
TNHLIRFIAR | QQNIKNARKS | PLAQDSPSQG | SPALYRNVNT | LRERISAFQS |
200:
AFHSIKENEK | MTGCLEFSEA | GKESEMTDLT | RKEGLSACQQ | SGFPAVLSSK |
250:
RRRISYQRDS | DENLTDAEGK | VIGLQIFNID | TDRACAVETS | VDLSEISSKL |
300:
GSTQSGFLVE | ESLPLSELTE | TSNALKVADC | VVGKGSSDAV | SPDTFTAEVS |
350:
SDAVPDVRSP | ATPACRRDLP | TPKTFVLRSV | LKKPSVKMCL | ESLQEHCNNL |
400:
YDDDGTHPSL | ISNLPNCCKE | KEAEDEENFE | APAFLNMRKR | KRVTFGEDLS |
450:
PEVFDESLPA | NTPLRKGGTP | VCKKDFSGLS | SLLLEQSPVP | EPLPQPDFDD |
500:
KGENLENIEP | LQVSFAVLSS | PNKSSISETL | SGTDTFSSSN | NHEKISSPKV |
550:
GRITRTSNRR | NQLVSVVEES | VCNLLNTEVQ | PCKEKKINRR | KSQETKCTKR |
600:
ALPKKSQVLK | SCRKKKGKGK | KSVQKSLYGE | RDIASKKPLL | SPIPELPEVP |
650:
EMTPSIPSIR | RLGSGYFSSN | GKLEEVKTPK | NPVKRKDLLR | HDPDLHMHQG |
700:
YDKYDVSEFC | SYIKSSSSLG | NATSDEDPNT | NIMNINENKN | IPKAKNKSES |
750:
ENEPKAGTDS | PVSCASVTEE | RVASDSPKPA | LTLQQGQEFS | AGGQNAENLC |
800:
QFFKISPDLN | IKCERKDDFL | GAAEGKLQCN | RLMPNSQKDC | HCLGDVLIEN |
850:
TKESKSQSED | LGRKPMESSS | VVSCRDRKDR | RRSMCYSDGR | SLHLEKNGNH |
900:
TPSSSVGSSV | EISLENSELF | KDLSDAIEQT | FQRRNSETKV | RRSTRLQKDL |
950:
ENEGLVWISL | PLPSTSQKAK | RRTICTFDSS | GFESMSPIKE | TVSSRQKPQM |
1000:
APPVSDPENS | QGPAAGSSDE | PGKRRKSFCI | STLANTKATS | QFKGYRRRSS |
1023:
LNGKGESSLT | ALERIEHNGE | RKQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Human Cell division cycle-associated protein 2
ELISA Kit for Human Cell division cycle-associated protein 2
ELISA Kit for Human Cell division cycle-associated protein 2
CLIA Kit for Human Cell division cycle-associated protein 2
CLIA Kit for Human Cell division cycle-associated protein 2
CLIA Kit for Human Cell division cycle-associated protein 2
Polyclonal Antibody for Human Cell division cycle-associated protein 2
Polyclonal Antibody for Human Cell division cycle-associated protein 2
Polyclonal Antibody for Human Cell division cycle-associated protein 2
Monoclonal Antibody for Human Cell division cycle-associated protein 2
Monoclonal Antibody for Human Cell division cycle-associated protein 2
Monoclonal Antibody for Human Cell division cycle-associated protein 2
Protein for Human Cell division cycle-associated protein 2
Protein for Human Cell division cycle-associated protein 2
Protein for Human Cell division cycle-associated protein 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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Endometrial tumor .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 561-1023 (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Leukemic T-cell .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98; SER-400; SER-437 AND SER-591;VARIANT [LARGE SCALE ANALYSIS] ILE-717;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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