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Index > Protein center > MB21D1(Gene name) > Human
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  • MB21D1 (Gene name),
  • Cyclic GMP-AMP synthase (Protein name ),  CGAS_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    MB21D1(C6orf150);
    Protein name:
    Cyclic GMP-AMP synthase(cGAMP synthase);
    Alternative:
    Mab-21 domain-containing protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
    Subcellular Location:
    Cytoplasm Cytosol
    Protein Attributes:
    Sequence length:
    522
    Sequence:
    50:
    MQPWHGKAMQ | RASEAGATAP | KASARNARGA | PMDPTESPAA | PEAALPKAGK | 
    100:
    FGPARKSGSR | QKKSAPDTQE | RPPVRATGAR | AKKAPQRAQD | TQPSDATSAP | 
    150:
    GAEGLEPPAA | REPALSRAGS | CRQRGARCST | KPRPPPGPWD | VPSPGLPVSA | 
    200:
    PILVRRDAAP | GASKLRAVLE | KLKLSRDDIS | TAAGMVKGVV | DHLLLRLKCD | 
    250:
    SAFRGVGLLN | TGSYYEHVKI | SAPNEFDVMF | KLEVPRIQLE | EYSNTRAYYF | 
    300:
    VKFKRNPKEN | PLSQFLEGEI | LSASKMLSKF | RKIIKEEIND | IKDTDVIMKR | 
    350:
    KRGGSPAVTL | LISEKISVDI | TLALESKSSW | PASTQEGLRI | QNWLSAKVRK | 
    400:
    QLRLKPFYLV | PKHAKEGNGF | QEETWRLSFS | HIEKEILNNH | GKSKTCCENK | 
    450:
    EEKCCRKDCL | KLMKYLLEQL | KERFKDKKHL | DKFSSYHVKT | AFFHVCTQNP | 
    500:
    QDSQWDRKDL | GLCFDNCVTY | FLQCLRTEKL | ENYFIPEFNL | FSSNLIDKRS | 
    522:
    KEFLTKQIEY | ERNNEFPVFD | EF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human cGAMP synthase
    ELISA Kit for Human cGAMP synthase
    ELISA Kit for Human cGAMP synthase
    ELISA Kit for Human cGAMP synthase
    ELISA Kit for Human cGAMP synthase
    CLIA Kit for Human cGAMP synthase
    CLIA Kit for Human cGAMP synthase
    CLIA Kit for Human cGAMP synthase
    CLIA Kit for Human cGAMP synthase
    CLIA Kit for Human cGAMP synthase
    Polyclonal Antibody for Human cGAMP synthase
    Polyclonal Antibody for Human cGAMP synthase
    Polyclonal Antibody for Human cGAMP synthase
    Polyclonal Antibody for Human cGAMP synthase
    Polyclonal Antibody for Human cGAMP synthase
    Monoclonal Antibody for Human cGAMP synthase
    Monoclonal Antibody for Human cGAMP synthase
    Monoclonal Antibody for Human cGAMP synthase
    Monoclonal Antibody for Human cGAMP synthase
    Monoclonal Antibody for Human cGAMP synthase
    Protein for Human cGAMP synthase
    Protein for Human cGAMP synthase
    Protein for Human cGAMP synthase
    Protein for Human cGAMP synthase
    Protein for Human cGAMP synthase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway."
      Sun L. , Wu J. , Du F. , Chen X. , Chen Z.J.
      Science339:786-791(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;DNA-BINDING;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASN-35
      tissue: Spleen.
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS ASN-35 AND HIS-261
      tissue: Brain.
      tissue: Prostate.
      tissue: Testis.
    5. 5.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1; LYS-7 AND LYS-414;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    6. 6.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 7.
      "A diverse range of gene products are effectors of the type I interferon antiviral response."
      Schoggins J.W. , Wilson S.J. , Panis M. , Murphy M.Y. , Jones C.T. , Bieniasz P. , Rice C.M.
      Nature472:481-485(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    8. 8.
      "The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING."
      Diner E.J. , Burdette D.L. , Wilson S.C. , Monroe K.M. , Kellenberger C.A. , Hyodo M. , Hayakawa Y. , Hammond M.C. , Vance R.E.
      Cell Rep.3:1355-1361(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF LYS-173; LEU-174; ARG-176; 212-GLY-SER-213; GLU-225; ASP-227; 396-CYS-CYS-397; LYS-407 AND LYS-411
    10. 10.
      "Structure-guided reprogramming of human cGAS dinucleotide linkage specificity."
      Kranzusch P.J. , Lee A.S. , Wilson S.C. , Solovykh M.S. , Vance R.E. , Berger J.M. , Doudna J.A.
      Cell158:1011-1021(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF THR-211; ARG-376 AND TYR-436
    11. 11.
      "Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity."
      Kranzusch P.J. , Lee A.S. , Berger J.M. , Doudna J.A.
      Cell Rep.3:1362-1368(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 157-222 IN COMPLEX WITH ZINC IONS;FUNCTION;CATALYTIC ACTIVITY;DOMAIN;ENZYME REGULATION;DNA-BINDING;MUTAGENESIS OF LYS-171; LYS-173; GLU-225; ASP-227; LYS-384; HIS-390; LYS-394; CYS-396; CYS-397; CYS-404; LYS-407 AND LYS-414
    12. 12.
      "Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization."
      Li X. , Shu C. , Yi G. , Chaton C.T. , Shelton C.L. , Diao J. , Zuo X. , Kao C.C. , Herr A.B. , Li P.
      Immunity39:1019-1031(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 157-522 IN COMPLEX WITH ZINC
    13. 13.
      "Structural and functional analyses of DNA-sensing and immune activation by human cGAS."
      Kato K. , Ishii R. , Goto E. , Ishitani R. , Tokunaga F. , Nureki O.
      PLoS ONE8:E76983-E76983(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 161-522 IN COMPLEX WITH ZINC;FUNCTION;DNA-BINDING;MUTAGENESIS OF LYS-384; LYS-400; LYS-403; LYS-407 AND LYS-411
    14. 14.
      "The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop."
      Zhang X. , Wu J. , Du F. , Xu H. , Sun L. , Chen Z. , Brautigam C.A. , Zhang X. , Chen Z.J.
      Cell Rep.6:421-430(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 161-522 IN COMPLEX WITH ZINC AND CYCLIC GMP-AMP;FUNCTION;MUTAGENESIS OF ARG-236; LYS-254; LYS-327; LYS-347; ARG-353 AND LYS-394
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