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Index > Protein center > Mb21d1(Gene name) > Mouse
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  • Mb21d1 (Gene name),
  • Cyclic GMP-AMP synthase (Protein name ),  CGAS_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Mb21d1;
    Protein name:
    Cyclic GMP-AMP synthase(cGAMP synthase);
    Alternative:
    Mab-21 domain-containing protein 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
    Subcellular Location:
    Cytoplasm Cytosol
    Protein Attributes:
    Sequence length:
    507
    Sequence:
    50:
    MEDPRRRTTA | PRAKKPSAKR | APTQPSRTRA | HAESCGPQRG | ARSRRAERDG | 
    100:
    DTTEKPRAPG | PRVHPARATE | LTKDAQPSAM | DAAGATARPA | VRVPQQQAIL | 
    150:
    DPELPAVREP | QPPADPEARK | VVRGPSHRRG | ARSTGQPRAP | RGSRKEPDKL | 
    200:
    KKVLDKLRLK | RKDISEAAET | VNKVVERLLR | RMQKRESEFK | GVEQLNTGSY | 
    250:
    YEHVKISAPN | EFDVMFKLEV | PRIELQEYYE | TGAFYLVKFK | RIPRGNPLSH | 
    300:
    FLEGEVLSAT | KMLSKFRKII | KEEVKEIKDI | DVSVEKEKPG | SPAVTLLIRN | 
    350:
    PEEISVDIIL | ALESKGSWPI | STKEGLPIQG | WLGTKVRTNL | RREPFYLVPK | 
    400:
    NAKDGNSFQG | ETWRLSFSHT | EKYILNNHGI | EKTCCESSGA | KCCRKECLKL | 
    450:
    MKYLLEQLKK | EFQELDAFCS | YHVKTAIFHM | WTQDPQDSQW | DPRNLSSCFD | 
    500:
    KLLAFFLECL | RTEKLDHYFI | PKFNLFSQEL | IDRKSKEFLS | KKIEYERNNG | 
    507:
    FPIFDKL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse cGAMP synthase
    ELISA Kit for Mouse cGAMP synthase
    ELISA Kit for Mouse cGAMP synthase
    ELISA Kit for Mouse cGAMP synthase
    ELISA Kit for Mouse cGAMP synthase
    CLIA Kit for Mouse cGAMP synthase
    CLIA Kit for Mouse cGAMP synthase
    CLIA Kit for Mouse cGAMP synthase
    CLIA Kit for Mouse cGAMP synthase
    CLIA Kit for Mouse cGAMP synthase
    Polyclonal Antibody for Mouse cGAMP synthase
    Polyclonal Antibody for Mouse cGAMP synthase
    Polyclonal Antibody for Mouse cGAMP synthase
    Polyclonal Antibody for Mouse cGAMP synthase
    Polyclonal Antibody for Mouse cGAMP synthase
    Monoclonal Antibody for Mouse cGAMP synthase
    Monoclonal Antibody for Mouse cGAMP synthase
    Monoclonal Antibody for Mouse cGAMP synthase
    Monoclonal Antibody for Mouse cGAMP synthase
    Monoclonal Antibody for Mouse cGAMP synthase
    Protein for Mouse cGAMP synthase
    Protein for Mouse cGAMP synthase
    Protein for Mouse cGAMP synthase
    Protein for Mouse cGAMP synthase
    Protein for Mouse cGAMP synthase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway."
      Sun L. , Wu J. , Du F. , Chen X. , Chen Z.J.
      Science339:786-791(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;DNA-BINDING;SUBCELLULAR LOCATION;MUTAGENESIS OF GLU-211 AND ASP-213
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Mammary gland.
      tissue: Ovary.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Limb.
    6. 6.
      "cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING."
      Ablasser A. , Goldeck M. , Cavlar T. , Deimling T. , Witte G. , Rohl I. , Hopfner K.P. , Ludwig J. , Hornung V.
      Nature498:380-384(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase."
      Gao P. , Ascano M. , Wu Y. , Barchet W. , Gaffney B.L. , Zillinger T. , Serganov A.A. , Liu Y. , Jones R.A. , Hartmann G. , Tuschl T. , Patel D.J.
      Cell153:1094-1107(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) OF 147-507 IN COMPLEXES WITH DNA; GMP; GTP; ATP; CYCLIC GMP-AMP; MAGNESIUM AND ZINC IONS;FUNCTION;COFACTOR;CATALYTIC ACTIVITY;DNA-BINDING
    8. 8.
      "The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop."
      Zhang X. , Wu J. , Du F. , Xu H. , Sun L. , Chen Z. , Brautigam C.A. , Zhang X. , Chen Z.J.
      Cell Rep.6:421-430(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS) OF 147-507 IN COMPLEX WITH ZINC;SUBUNIT
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