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Index > Protein center > CSGALNACT1(Gene name) > Human
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  • CSGALNACT1 (Gene name),
  • Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (Protein name ),  CGAT1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CSGALNACT1(UNQ656/PRO1287;CHGN;GALNACT1);
    Protein name:
    Chondroitin sulfate N-acetylgalactosaminyltransferase 1(CsGalNAcT-1);
    Alternative:
    Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1(Beta4GalNAcT-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage.
    Subcellular Location:
    Golgi apparatus Golgi stack membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    532
    Sequence:
    50:
    MMMVRRGLLA | WISRVVVLLV | LLCCAISVLY | MLACTPKGDE | EQLALPRANS | 
    100:
    PTGKEGYQAV | LQEWEEQHRN | YVSSLKRQIA | QLKEELQERS | EQLRNGQYQA | 
    150:
    SDAAGLGLDR | SPPEKTQADL | LAFLHSQVDK | AEVNAGVKLA | TEYAAVPFDS | 
    200:
    FTLQKVYQLE | TGLTRHPEEK | PVRKDKRDEL | VEAIESALET | LNSPAENSPN | 
    250:
    HRPYTASDFI | EGIYRTERDK | GTLYELTFKG | DHKHEFKRLI | LFRPFGPIMK | 
    300:
    VKNEKLNMAN | TLINVIVPLA | KRVDKFRQFM | QNFREMCIEQ | DGRVHLTVVY | 
    350:
    FGKEEINEVK | GILENTSKAA | NFRNFTFIQL | NGEFSRGKGL | DVGARFWKGS | 
    400:
    NVLLFFCDVD | IYFTSEFLNT | CRLNTQPGKK | VFYPVLFSQY | NPGIIYGHHD | 
    450:
    AVPPLEQQLV | IKKETGFWRD | FGFGMTCQYR | SDFINIGGFD | LDIKGWGGED | 
    500:
    VHLYRKYLHS | NLIVVRTPVR | GLFHLWHEKR | CMDELTPEQY | KMCMQSKAMN | 
    532:
    EASHGQLGML | VFRHEIEAHL | RKQKQKTSSK | KT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human CsGalNAcT-1
    ELISA Kit for Human CsGalNAcT-1
    CLIA Kit for Human CsGalNAcT-1
    CLIA Kit for Human CsGalNAcT-1
    Polyclonal Antibody for Human CsGalNAcT-1
    Polyclonal Antibody for Human CsGalNAcT-1
    Monoclonal Antibody for Human CsGalNAcT-1
    Monoclonal Antibody for Human CsGalNAcT-1
    Protein for Human CsGalNAcT-1
    Protein for Human CsGalNAcT-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate."
      Uyama T. , Kitagawa H. , Tamura J. , Sugahara K.
      J. Biol. Chem.277:8841-8846(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;GLYCOSYLATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANT ASN-193
      tissue: Melanoma.
    2. 2.
      "Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis."
      Gotoh M. , Sato T. , Akashima T. , Iwasaki H. , Kameyama A. , Mochizuki H. , Yada T. , Inaba N. , Zhang Y. , Kikuchi N. , Kwon Y.-D. , Togayachi A. , Kudo T. , Nishihara S. , Watanabe H. , Kimata K. , Narimatsu H.
      J. Biol. Chem.277:38189-38196(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;VARIANT ASN-193
    3. 3.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASN-193
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Placenta.
      tissue: Thalamus.
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT ASN-193
      tissue: Placenta.
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 381-532;VARIANT ASN-193
      tissue: Melanoma.
    7. 8.
      "Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate."
      Sato T. , Gotoh M. , Kiyohara K. , Akashima T. , Iwasaki H. , Kameyama A. , Mochizuki H. , Yada T. , Inaba N. , Togayachi A. , Kudo T. , Asada M. , Watanabe H. , Imamura T. , Kimata K. , Narimatsu H.
      J. Biol. Chem.278:3063-3071(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    8. 9.
      "Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage."
      Sakai K. , Kimata K. , Sato T. , Gotoh M. , Narimatsu H. , Shinomiya K. , Watanabe H.
      J. Biol. Chem.282:4152-4161(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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