Chfr ELISA Kit for Mouse(Mus musculus) | EIAab.comChfr ELISA Kit for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Chfr(Gene name) > Mouse

Chfr (Gene name),

E3 ubiquitin-protein ligase CHFR (Protein name ), CHFR_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Chfr;

Protein name:

E3 ubiquitin-protein ligase CHFR;

Alternative:

Checkpoint with forkhead and RING finger domains protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with HDAC1 and HDAC2. Interacts with PML (with sumoylated form of PML).

Function:

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Subcellular Location:

Nucleus PML body

Protein Attributes:

Sequence length:

664

Sequence:

50:

100:

150:

200:

250:

300: