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Index > Protein center > CHKB(Gene name) > Human
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  • CHKB (Gene name),
  • Choline/ethanolamine kinase (Protein name ),  CHKB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CHKB(CHETK;CHKL);
    Protein name:
    Choline/ethanolamine kinase;
    Alternative:
    Choline kinase-like protein;2.7.1.32;Choline kinase beta(CK;CKB);Ethanolamine kinase beta(EKB);2.7.1.82;Ethanolamine kinase(EK);choline/ethanolamine kinase beta(CKEKB);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer, and heterodimer with CHKA.
    Function:
    Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    395
    Sequence:
    50:
    MAAEATAVAG | SGAVGGCLAK | DGLQQSKCPD | TTPKRRRASS | LSRDAERRAY | 
    100:
    QWCREYLGGA | WRRVQPEELR | VYPVSGGLSN | LLFRCSLPDH | LPSVGEEPRE | 
    150:
    VLLRLYGAIL | QGVDSLVLES | VMFAILAERS | LGPQLYGVFP | EGRLEQYIPS | 
    200:
    RPLKTQELRE | PVLSAAIATK | MAQFHGMEMP | FTKEPHWLFG | TMERYLKQIQ | 
    250:
    DLPPTGLPEM | NLLEMYSLKD | EMGNLRKLLE | STPSPVVFCH | NDIQEGNILL | 
    300:
    LSEPENADSL | MLVDFEYSSY | NYRGFDIGNH | FCEWVYDYTH | EEWPFYKARP | 
    350:
    TDYPTQEQQL | HFIRHYLAEA | KKGETLSQEE | QRKLEEDLLV | EVSRYALASH | 
    395:
    FFWGLWSILQ | ASMSTIEFGY | LDYAQSRFQF | YFQQKGQLTS | VHSSS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    SMR:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Choline/ethanolamine kinase
    Cat.:
    E11702m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Choline/ethanolamine kinase
    Cat.:
    E11702h
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Choline/ethanolamine kinase
    Cat.:
    E11702r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Choline/ethanolamine kinase
    Cat.:
    U11702h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Choline/ethanolamine kinase
    Cat.:
    U11702r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Choline/ethanolamine kinase
    Cat.:
    U11702m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Choline/ethanolamine kinase
    Cat.:
    P11702Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Choline/ethanolamine kinase
    Cat.:
    P11702Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Choline/ethanolamine kinase
    Cat.:
    P11702Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Choline/ethanolamine kinase
    Monoclonal Antibody for Human Choline/ethanolamine kinase
    Monoclonal Antibody for Human Choline/ethanolamine kinase
    Protein for Human Choline/ethanolamine kinase
    Protein for Human Choline/ethanolamine kinase
    Protein for Human Choline/ethanolamine kinase

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    Precision
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    Linearity
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    References
    1. 1.
      "Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I."
      Yamazaki N. , Shinohara Y. , Kajimoto K. , Shindo M. , Terada H.
      J. Biol. Chem.275:31739-31746(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
    2. 2.
      Smink L.J. , Huckle E.J.
      Submitted (1999-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Lung.
    8. 8.
      Bienvenut W.V. , Kanor S. , Tissot J.-D. , Quadroni M.
      Submitted (2006-05) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-19;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: T-cell.
    9. 9.
      "Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment."
      Gallego-Ortega D. , Ramirez de Molina A. , Ramos M.A. , Valdes-Mora F. , Barderas M.G. , Sarmentero-Estrada J. , Lacal J.C.
      PLoS ONE4:E7819-E7819(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES
    10. 10.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide."
      Structural genomics consortium (SGC)
      Submitted (2009-09) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 14-395 IN COMPLEX WITH ADP; MAGNESIUM IONS AND HEMICHOLINIUM-3
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