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Index > Protein center > Chmp2a(Gene name) > Mouse
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  • Chmp2a (Gene name),
  • Charged multivesicular body protein 2a (Protein name ),  CHM2A_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Chmp2a;
    Protein name:
    Charged multivesicular body protein 2a;
    Alternative:
    Vacuolar protein sorting-associated protein 2(mVps2);Chromatin-modifying protein 2a(CHMP2a);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. In vitro, heteromerizes with CHMP3 (but not CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. Interacts with CHMP1B, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP5. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with MITD1. Interacts with VTA1; the interaction probably involves the open conformation of CHMP2A.
    Function:
    Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
    Subcellular Location:
    Late endosome membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
    Protein Attributes:
    Sequence length:
    222
    Sequence:
    50:
    MDLLFGRRKT | PEELLRQNQR | ALNRAMRELD | RERQKLETQE | KKIIADIKKM | 
    100:
    AKQGQMDAVR | IMAKDLVRTR | RYVRKFVLMR | ANIQAVSLKI | QTLKSNNSMA | 
    150:
    QAMKGVTKAM | GTMNRQLKLP | QIQKIMMEFE | RQAEIMDMKE | EMMNDAIDDA | 
    200:
    MGDEEDEEES | DAVVSQVLDE | LGLSLTDELS | NLPSTGGSLS | VAAGGKKAEA | 
    222:
    TASALADADA | DLEERLKNLR | RD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    KEGG:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Charged multivesicular body protein 2a
    Cat.:
    E13986h
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    Packing:
    96T
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    ELISA Kit for Mouse Charged multivesicular body protein 2a
    Cat.:
    E13986m
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    Packing:
    96T
    ELISA Kit for Mouse Charged multivesicular body protein 2a
    Cat.:
    E13986c
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    Packing:
    96T
    CLIA Kit for Mouse Charged multivesicular body protein 2a
    Cat.:
    U13986h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Charged multivesicular body protein 2a
    Cat.:
    U13986m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Charged multivesicular body protein 2a
    Cat.:
    U13986c
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Charged multivesicular body protein 2a
    Polyclonal Antibody for Mouse Charged multivesicular body protein 2a
    Cat.:
    P13986Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Charged multivesicular body protein 2a
    Cat.:
    P13986Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Charged multivesicular body protein 2a
    Monoclonal Antibody for Mouse Charged multivesicular body protein 2a
    Monoclonal Antibody for Mouse Charged multivesicular body protein 2a
    Protein for Mouse Charged multivesicular body protein 2a
    Protein for Mouse Charged multivesicular body protein 2a
    Protein for Mouse Charged multivesicular body protein 2a

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    Linearity
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    References
    1. 1.
      "Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B."
      Fujita H. , Umezuki Y. , Imamura K. , Ishikawa D. , Uchimura S. , Nara A. , Yoshimori T. , Hayashizaki Y. , Kawai J. , Ishidoh K. , Tanaka Y. , Himeno M.
      J. Cell Sci.117:2997-3009(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH VPS4B
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Cerebellum.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    4. 4.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
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