Protein name:
Charged multivesicular body protein 2a ;
Alternative:
Vacuolar protein sorting-associated protein 2 (mVps2) ;Chromatin-modifying protein 2a (CHMP2a) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. In vitro, heteromerizes with CHMP3 (but not CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. Interacts with CHMP1B, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP5. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with MITD1. Interacts with VTA1; the interaction probably involves the open conformation of CHMP2A.
Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Subcellular Location:
Late endosome membrane
Peripheral membrane protein
Cytoplasmic side
Cytoplasm
Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Protein Attributes:
50:
MDLLFGRRKT | PEELLRQNQR | ALNRAMRELD | RERQKLETQE | KKIIADIKKM |
100:
AKQGQMDAVR | IMAKDLVRTR | RYVRKFVLMR | ANIQAVSLKI | QTLKSNNSMA |
150:
QAMKGVTKAM | GTMNRQLKLP | QIQKIMMEFE | RQAEIMDMKE | EMMNDAIDDA |
200:
MGDEEDEEES | DAVVSQVLDE | LGLSLTDELS | NLPSTGGSLS | VAAGGKKAEA |
222:
TASALADADA | DLEERLKNLR | RD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
ELISA Kit for Mouse Charged multivesicular body protein 2a
ELISA Kit for Mouse Charged multivesicular body protein 2a
ELISA Kit for Mouse Charged multivesicular body protein 2a
CLIA Kit for Mouse Charged multivesicular body protein 2a
CLIA Kit for Mouse Charged multivesicular body protein 2a
CLIA Kit for Mouse Charged multivesicular body protein 2a
Polyclonal Antibody for Mouse Charged multivesicular body protein 2a
Polyclonal Antibody for Mouse Charged multivesicular body protein 2a
Polyclonal Antibody for Mouse Charged multivesicular body protein 2a
Monoclonal Antibody for Mouse Charged multivesicular body protein 2a
Monoclonal Antibody for Mouse Charged multivesicular body protein 2a
Monoclonal Antibody for Mouse Charged multivesicular body protein 2a
Protein for Mouse Charged multivesicular body protein 2a
Protein for Mouse Charged multivesicular body protein 2a
Protein for Mouse Charged multivesicular body protein 2a
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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"Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B."
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J. Cell Sci.117:2997-3009(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH VPS4B
2.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Cerebellum .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Mammary tumor .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Brain .