Chmp5 ELISA Kit for Mouse(Mus musculus) | EIAab.comChmp5 ELISA Kit for Mouse(Mus musculus)

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Chmp5 (Gene name),

Charged multivesicular body protein 5 (Protein name ), CHMP5_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Chmp5(Snf7dc2);

Protein name:

Charged multivesicular body protein 5;

Alternative:

SNF7 domain-containing protein 2;Chromatin-modifying protein 5;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with VTA1. Interacts with CHMP2A. Interacts with VTA1; the interaction involves soluble CHMP5.

Function:

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

Subcellular Location:

Cytoplasm cytosol Endosome membrane Peripheral membrane protein Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.

Protein Attributes:

Sequence length:

219

Sequence:

50:

100:

150:

200:

219:

KNKDGVLVDE | FGLPQIPAS

3D Structure:

N/A