Chp ELISA Kit for Rat(Rattus norvegicus) | EIAab.comChp ELISA Kit for Rat(Rattus norvegicus)

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Chp (Gene name),

Calcium-binding protein p22 (Protein name ), CHP1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Chp(Chp);

Protein name:

Calcium-binding protein p22;

Alternative:

Calcium-binding protein CHP;Calcineurin homologous protein;EF-hand calcium-binding domain-containing protein p22;Calcium-binding protein p22;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Specifically binds to SLC9A1/NHE1 at a domain that is critical for growth factor stimulation of exchange activity (By similarity). Monomer.

Function:

Required for constitutive membrane traffic. Inhibits GTPase-stimulated Na(+)/H(+) exchange. Also inhibits calcineurin phosphatase activity. Required for activity of SLC9A1/NHE1.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

195

Sequence:

50:

100:

150:

195:

QLGSIADRTI | QEADQDGDSA | ISFTEFVKVL | EKVDVEQKMS | IRFLH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P61023

KEGG:

rno:64152

STRING:

10116.ENSRNOP00000053243

SMR:

P61023

Pfam:

PF13499

UniGene:

Rn.11041

Uniprot:

P61023

FOR

ELISA Kit for Rat Calcium-binding protein p22

CLIA Kit for Rat Calcium-binding protein p22

Polyclonal Antibody for Rat Calcium-binding protein p22

Monoclonal Antibody for Rat Calcium-binding protein p22

Protein for Rat Calcium-binding protein p22

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic."
Barroso M.R. , Bernd K.K. , Dewitt N.D. , Chang A. , Mills K. , Sztul E.S.
J. Biol. Chem.271:10183-10187(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION IN EXOCYTIC MEMBRANE TRAFFIC;CALCIUM-BINDING;MUTAGENESIS OF GLU-134;TISSUE SPECIFICITY
tissue: Liver.
2.

"A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na+/H+ exchanger."
Matsumoto M. , Miyake Y. , Nagita M. , Inoue H. , Shitakubo D. , Takemoto K. , Ohtsuka C. , Murakami H. , Nakamura N. , Kanazawa H.
J. Biochem.130:217-225(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH STK17B
tissue: Brain.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Prostate.
4.

"The EF-hand Ca(2+)-binding protein p22 associates with microtubules in an N-myristoylation-dependent manner."
Timm S. , Titus B. , Bernd K. , Barroso M.
Mol. Biol. Cell10:3473-3488(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH MICROTUBULES;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
5.

"KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles."
Nakamura N. , Miyake Y. , Matsushita M. , Tanaka S. , Inoue H. , Kanazawa H.
J. Biochem.132:483-491(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIF1B;SUBCELLULAR LOCATION
6.

"The apoptosis-inducing protein kinase DRAK2 is inhibited in a calcium-dependent manner by the calcium-binding protein CHP."
Kuwahara H. , Kamei J. , Nakamura N. , Matsumoto M. , Inoue H. , Kanazawa H.
J. Biochem.134:245-250(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS STK17B KINASE INHIBITOR;INTERACTION WITH STK17B
7.

"Two nuclear export signals specify the cytoplasmic localization of calcineurin B homologous protein 1."
Nagita M. , Inoue H. , Nakamura N. , Kanazawa H.
J. Biochem.134:919-925(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;NUCLEAR EXPORT SIGNALS;MUTAGENESIS OF VAL-138; LEU-139; VAL-143; VAL-145; ILE-147; VAL-179; LEU-180; VAL-183 AND VAL-185
8.

"Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules."
Andrade J. , Pearce S.T. , Zhao H. , Barroso M.
Biochem. J.384:327-336(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GAPDH;ASSOCIATION WITH MICROTUBULES;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.

"The EF-hand Ca2+-binding protein p22 plays a role in microtubule and endoplasmic reticulum organization and dynamics with distinct Ca2+-binding requirements."
Andrade J. , Zhao H. , Titus B. , Timm Pearce S. , Barroso M.
Mol. Biol. Cell15:481-496(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF GLU-134
10.

"Nuclear-localized calcineurin homologous protein CHP1 interacts with upstream binding factor and inhibits ribosomal RNA synthesis."
Jimenez-Vidal M. , Srivastava J. , Putney L.K. , Barber D.L.
J. Biol. Chem.285:36260-36266(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSCRIPTION REGULATION;SUBCELLULAR LOCATION;MUTAGENESIS OF VAL-143; VAL-145; ILE-147; VAL-183 AND VAL-185
11.

"Dual functional significance of calcineurin homologous protein 1 binding to Na(+)/H(+) exchanger isoform 1."
Matsushita M. , Tanaka H. , Mitsui K. , Kanazawa H.
Am. J. Physiol.301:C280-C288(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
12.

"Crystallization and preliminary X-ray crystallographic analysis of rat calcineurin B homologous protein 1."
Naoe Y. , Arita K. , Hashimoto H. , Kanazawa H. , Sato M. , Shimizu T.
Acta Crystallogr. F61:612-613(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY X-RAY CRYSTALLOGRAPHY
13.

"Structural characterization of calcineurin B homologous protein 1."
Naoe Y. , Arita K. , Hashimoto H. , Kanazawa H. , Sato M. , Shimizu T.
J. Biol. Chem.280:32372-32378(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH CALCIUM IONS;SUBUNIT

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