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Index > Protein center > Cirbp(Gene name) > Mouse
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  • Cirbp (Gene name),
  • Cold-inducible RNA-binding protein (Protein name ),  CIRBP_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Cirbp(Cirp);
    Protein name:
    Cold-inducible RNA-binding protein;
    Alternative:
    Glycine-rich RNA-binding protein CIRP;A18 hnRNP;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with EIF4G1. Associates with ribosomes.
    Function:
    Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold-induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN.
    Subcellular Location:
    Nucleus nucleoplasm Cytoplasm Translocates from the nucleus to the cytoplasm after exposure to UV radiation (By similarity). Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins.
    Protein Attributes:
    Sequence length:
    172
    Sequence:
    50:
    MASDEGKLFV | GGLSFDTNEQ | ALEQVFSKYG | QISEVVVVKD | RETQRSRGFG | 
    100:
    FVTFENIDDA | KDAMMAMNGK | SVDGRQIRVD | QAGKSSDNRS | RGYRGGSAGG | 
    150:
    RGFFRGGRSR | GRGFSRGGGD | RGYGGGRFES | RSGGYGGSRD | YYASRSQGGS | 
    172:
    YGYRSSGGSY | RDSYDSYATH | NE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Cold-inducible RNA-binding protein
    Cat.:
    E12931r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Cold-inducible RNA-binding protein
    Cat.:
    E12931m
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Cold-inducible RNA-binding protein
    Cat.:
    E12931h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Cold-inducible RNA-binding protein
    Cat.:
    U12931m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cold-inducible RNA-binding protein
    Cat.:
    U12931h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cold-inducible RNA-binding protein
    Cat.:
    U12931r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Cold-inducible RNA-binding protein
    Polyclonal Antibody for Mouse Cold-inducible RNA-binding protein
    Polyclonal Antibody for Mouse Cold-inducible RNA-binding protein
    Cat.:
    P12931Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Cold-inducible RNA-binding protein
    Monoclonal Antibody for Mouse Cold-inducible RNA-binding protein
    Monoclonal Antibody for Mouse Cold-inducible RNA-binding protein
    Protein for Mouse Cold-inducible RNA-binding protein
    Protein for Mouse Cold-inducible RNA-binding protein
    Protein for Mouse Cold-inducible RNA-binding protein

    R&D Technical Data
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    Linearity
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    References
    1. 1.
      "A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth."
      Nishiyama H. , Itoh K. , Kaneko Y. , Kishishita M. , Yoshida O. , Fujita J.
      J. Cell Biol.137:899-908(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INDUCTION BY COLD-SHOCK
      strain: DDY/STD.
      tissue: Testis.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Head.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Eye.
    4. 4.
      "The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor."
      De Leeuw F. , Zhang T. , Wauquier C. , Huez G. , Kruys V. , Gueydan C.
      Exp. Cell Res.313:4130-4144(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;METHYLATION;SUBCELLULAR LOCATION;MUTAGENESIS OF ARG-91; ARG-94; ARG-101; ARG-105; ARG-108; ARG-110; ARG-112; ARG-116; ARG-121; ARG-127 AND ARG-131
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