Protein name:
Cytokine-inducible SH2-containing protein (CIS) ;
Alternative:
Suppressor of cytokine signaling (SOCS) ;CIS-1 ;
Organism:
Chicken (Gallus gallus).
General Annotation
Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Location:
N/A
Protein Attributes:
50:
MILCVPGPHP | LLAEEKIQRL | SLRGIAEDLT | EHIMQPLPVP | AFPEEPAPTF |
100:
AAPEPDGSAP | QTRDPEEDLL | CIAKTFSYLR | ESGWYWGSIT | ASEAKQHLQK |
150:
MPEGTFLVRD | STHPSYLFTL | SVKTNRGPTN | VRIEYADSKF | RLDSNYLSKP |
200:
RILAFPDVVS | LIQHYVTSCT | TESKSEAPYP | PPAPLPPVQK | EVAVAAVHLK |
249:
LLRPLGRRDS | IPSLQHLCRL | RINRCTTEVE | RLPLPRRMGD | YLKQYPFQL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Bovine
Chicken
Mouse
Human
ELISA Kit for Chicken CIS
ELISA Kit for Chicken CIS
ELISA Kit for Chicken CIS
ELISA Kit for Chicken CIS
ELISA Kit for Chicken CIS
Polyclonal Antibody for Chicken CIS
Polyclonal Antibody for Chicken CIS
Polyclonal Antibody for Chicken CIS
Polyclonal Antibody for Chicken CIS
Polyclonal Antibody for Chicken CIS
Monoclonal Antibody for Chicken CIS
Monoclonal Antibody for Chicken CIS
Monoclonal Antibody for Chicken CIS
Monoclonal Antibody for Chicken CIS
Monoclonal Antibody for Chicken CIS
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
White leghorn .