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Index > Protein center > CISH(Gene name) > Chicken
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  • CISH (Gene name),
  • Cytokine-inducible SH2-containing protein (Protein name ),  CISH_CHICK from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CISH(CIS);
    Protein name:
    Cytokine-inducible SH2-containing protein(CIS);
    Alternative:
    Suppressor of cytokine signaling(SOCS);CIS-1;
    Organism:
    Chicken (Gallus gallus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    249
    Sequence:
    50:
    MILCVPGPHP | LLAEEKIQRL | SLRGIAEDLT | EHIMQPLPVP | AFPEEPAPTF | 
    100:
    AAPEPDGSAP | QTRDPEEDLL | CIAKTFSYLR | ESGWYWGSIT | ASEAKQHLQK | 
    150:
    MPEGTFLVRD | STHPSYLFTL | SVKTNRGPTN | VRIEYADSKF | RLDSNYLSKP | 
    200:
    RILAFPDVVS | LIQHYVTSCT | TESKSEAPYP | PPAPLPPVQK | EVAVAAVHLK | 
    249:
    LLRPLGRRDS | IPSLQHLCRL | RINRCTTEVE | RLPLPRRMGD | YLKQYPFQL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Chicken CIS
    ELISA Kit for Chicken CIS
    ELISA Kit for Chicken CIS
    ELISA Kit for Chicken CIS
    ELISA Kit for Chicken CIS
    CLIA Kit for Chicken CIS
    CLIA Kit for Chicken CIS
    CLIA Kit for Chicken CIS
    CLIA Kit for Chicken CIS
    CLIA Kit for Chicken CIS
    Polyclonal Antibody for Chicken CIS
    Polyclonal Antibody for Chicken CIS
    Polyclonal Antibody for Chicken CIS
    Polyclonal Antibody for Chicken CIS
    Polyclonal Antibody for Chicken CIS
    Monoclonal Antibody for Chicken CIS
    Monoclonal Antibody for Chicken CIS
    Monoclonal Antibody for Chicken CIS
    Monoclonal Antibody for Chicken CIS
    Monoclonal Antibody for Chicken CIS
    Protein for Chicken CIS
    Protein for Chicken CIS
    Protein for Chicken CIS
    Protein for Chicken CIS
    Protein for Chicken CIS

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    References
    1. 1.
      "Identification and characterization of genes upregulated in cells transformed by v-Jun."
      Fu S.-L. , Waha A. , Vogt P.K.
      Oncogene19:3537-3545(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: White leghorn.
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