Protein name:
Cytokine-inducible SH2-containing protein (CIS) ;
Alternative:
Suppressor of cytokine signaling (SOCS) ;CIS-1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR).
Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Location:
N/A
Protein Attributes:
50:
MVLCVQGSCP | LLAVEQIGRR | PLWAQSLELP | GPAMQPLPTG | AFPEEVTEET |
100:
PVQAENEPKV | LDPEGDLLCI | AKTFSYLRES | GWYWGSITAS | EARQHLQKMP |
150:
EGTFLVRDST | HPSYLFTLSV | KTTRGPTNVR | IEYADSSFRL | DSNCLSRPRI |
200:
LAFPDVVSLV | QHYVASCAAD | TRSDSPDPAP | TPALPMSKQD | APSDSVLPIP |
250:
VATAVHLKLV | QPFVRRSSAR | SLQHLCRLVI | NRLVADVDCL | PLPRRMADYL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Bovine
Chicken
Mouse
Human
Polyclonal Antibody for Mouse CIS
Polyclonal Antibody for Mouse CIS
Polyclonal Antibody for Mouse CIS
Polyclonal Antibody for Mouse CIS
Polyclonal Antibody for Mouse CIS
Monoclonal Antibody for Mouse CIS
Monoclonal Antibody for Mouse CIS
Monoclonal Antibody for Mouse CIS
Monoclonal Antibody for Mouse CIS
Monoclonal Antibody for Mouse CIS
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"The transcriptional landscape of the mammalian genome."
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
strain :
NOD .
tissue :
Pituitary .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Mammary gland .
tissue :
Salivary gland .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION