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Index > Protein center > Cish(Gene name) > Mouse
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  • Cish (Gene name),
  • Cytokine-inducible SH2-containing protein (Protein name ),  CISH_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Cish(Cis);
    Protein name:
    Cytokine-inducible SH2-containing protein(CIS);
    Alternative:
    Suppressor of cytokine signaling(SOCS);CIS-1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR).
    Function:
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    257
    Sequence:
    50:
    MVLCVQGSCP | LLAVEQIGRR | PLWAQSLELP | GPAMQPLPTG | AFPEEVTEET | 
    100:
    PVQAENEPKV | LDPEGDLLCI | AKTFSYLRES | GWYWGSITAS | EARQHLQKMP | 
    150:
    EGTFLVRDST | HPSYLFTLSV | KTTRGPTNVR | IEYADSSFRL | DSNCLSRPRI | 
    200:
    LAFPDVVSLV | QHYVASCAAD | TRSDSPDPAP | TPALPMSKQD | APSDSVLPIP | 
    250:
    VATAVHLKLV | QPFVRRSSAR | SLQHLCRLVI | NRLVADVDCL | PLPRRMADYL | 
    257:
    RQYPFQL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CIS
    ELISA Kit for Mouse CIS
    ELISA Kit for Mouse CIS
    ELISA Kit for Mouse CIS
    ELISA Kit for Mouse CIS
    CLIA Kit for Mouse CIS
    CLIA Kit for Mouse CIS
    CLIA Kit for Mouse CIS
    CLIA Kit for Mouse CIS
    CLIA Kit for Mouse CIS
    Polyclonal Antibody for Mouse CIS
    Polyclonal Antibody for Mouse CIS
    Polyclonal Antibody for Mouse CIS
    Polyclonal Antibody for Mouse CIS
    Polyclonal Antibody for Mouse CIS
    Monoclonal Antibody for Mouse CIS
    Monoclonal Antibody for Mouse CIS
    Monoclonal Antibody for Mouse CIS
    Monoclonal Antibody for Mouse CIS
    Monoclonal Antibody for Mouse CIS
    Protein for Mouse CIS
    Protein for Mouse CIS
    Protein for Mouse CIS
    Protein for Mouse CIS
    Protein for Mouse CIS

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors."
      Yoshimura A. , Ohkubo T. , Kiguchi T. , Jenkins N.A. , Gilbert D.J. , Copeland N.G. , Hara T. , Miyajima A.
      EMBO J.14:2816-2826(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Pituitary.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Mammary gland.
      tissue: Salivary gland.
    4. 4.
      "CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation."
      Matsumoto A. , Masuhara M. , Mitsui K. , Yokouchi M. , Ohtsubo M. , Misawa H. , Miyajima A. , Yoshimura A.
      Blood89:3148-3154(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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