Cish ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCish ELISA Kit for Rat(Rattus norvegicus)

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Cish (Gene name),

Cytokine-inducible SH2-containing protein (Protein name ), CISH_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Cish;

Protein name:

Cytokine-inducible SH2-containing protein(CIS);

Alternative:

Suppressor of cytokine signaling(SOCS);CIS-1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR).

Function:

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

256

Sequence:

50:

100:

150:

200:

250:

256:

QYPFQL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.14523

String:

O70512

Pfam:

PF00017

Uniprot:

O70512

FOR

ELISA Kit for Rat CIS

CLIA Kit for Rat CIS

Polyclonal Antibody for Rat CIS

Monoclonal Antibody for Rat CIS

Protein for Rat CIS

R&D Technical Data

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Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo."
Mao Y. , Ling P.R. , Fitzgibbons T.P. , McCowen K.C. , Frick G.P. , Bistrian B.R. , Smith R.J.
Endocrinology140:5505-5515(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE
strain: Sprague-Dawley.
tissue: Liver.
2.

"Cytokine inducible SH2-containing protein (CIS) from rat liver."
Siebenson L.N. , Berry S.A.
Submitted (2000-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 51-163
strain: Sprague-Dawley.
tissue: Liver.

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