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Index > Protein center > CITED4(Gene name) > Human
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  • CITED4 (Gene name),
  • Cbp/p300-interacting transactivator 4 (Protein name ),  CITE4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CITED4(MRG2);
    Protein name:
    Cbp/p300-interacting transactivator 4;
    Alternative:
    MSG1-related protein 2(MRG-2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts via its C-terminal region with the CH1 domain of CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms.
    Function:
    Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.
    Subcellular Location:
    Nucleus Cytoplasm
    Protein Attributes:
    Sequence length:
    184
    Sequence:
    50:
    MADHLMLAEG | YRLVQRPPSA | AAAHGPHALR | TLPPYAGPGL | DSGLRPRGAP | 
    100:
    LGPPPPRQPG | ALAYGAFGPP | SSFQPFPAVP | PPAAGIAHLQ | PVATPYPGRA | 
    150:
    AAPPNAPGGP | PGPQPAPSAA | APPPPAHALG | GMDAELIDEE | ALTSLELELG | 
    184:
    LHRVRELPEL | FLGQSEFDCF | SDLGSAPPAG | SVSC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cbp/p300-interacting transactivator 4
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    E4661r
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    ELISA Kit for Human Cbp/p300-interacting transactivator 4
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    E4661h
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    Packing:
    96T
    ELISA Kit for Human Cbp/p300-interacting transactivator 4
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    E4661b
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    ELISA Kit for Human Cbp/p300-interacting transactivator 4
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    E4661m
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    Packing:
    96T
    CLIA Kit for Human Cbp/p300-interacting transactivator 4
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    U4661r
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    96T
    CLIA Kit for Human Cbp/p300-interacting transactivator 4
    Cat.:
    U4661b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cbp/p300-interacting transactivator 4
    Cat.:
    U4661h
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    MSDS:
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    Packing:
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    CLIA Kit for Human Cbp/p300-interacting transactivator 4
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    U4661m
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    Packing:
    96T
    Polyclonal Antibody for Human Cbp/p300-interacting transactivator 4
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    P4661Rb-m
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    40ug/0.2ml
    Polyclonal Antibody for Human Cbp/p300-interacting transactivator 4
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    P4661Rb-r
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    Polyclonal Antibody for Human Cbp/p300-interacting transactivator 4
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cbp/p300-interacting transactivator 4
    Monoclonal Antibody for Human Cbp/p300-interacting transactivator 4
    Monoclonal Antibody for Human Cbp/p300-interacting transactivator 4
    Monoclonal Antibody for Human Cbp/p300-interacting transactivator 4
    Monoclonal Antibody for Human Cbp/p300-interacting transactivator 4
    Protein for Human Cbp/p300-interacting transactivator 4
    Protein for Human Cbp/p300-interacting transactivator 4
    Protein for Human Cbp/p300-interacting transactivator 4
    Protein for Human Cbp/p300-interacting transactivator 4

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    Linearity
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    References
    1. 1.
      "Structural and functional conservation of MRG family in system evolution."
      Zhuang D.Z. , Chou Y.-T. , Yang Y.-C.
      Submitted (2001-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2."
      Braganca J. , Swingler T. , Marques F.I.R. , Jones T. , Eloranta J.J. , Hurst H.C. , Shioda T. , Bhattacharya S.
      J. Biol. Chem.277:8559-8565(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION;INTERACTION WITH CREBBP; EP300 AND TFAP2;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pancreas.
    4. 4.
      "CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha."
      Fox S.B. , Braganca J. , Turley H. , Campo L. , Han C. , Gatter K.C. , Bhattacharya S. , Harris A.L.
      Cancer Res.64:6075-6081(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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