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Index > Protein center > CDK5RAP2(Gene name) > Human
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  • CDK5RAP2 (Gene name),
  • CDK5 regulatory subunit-associated protein 2 (Protein name ),  CK5P2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    CDK5RAP2(CEP215;KIAA1633);
    Protein name:
    CDK5 regulatory subunit-associated protein 2;
    Alternative:
    Centrosome-associated protein 215;CDK5 activator-binding protein C48;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5 (By similarity). Interacts with PCNT; the interaction is leading to centrosomal and Golgi localization of CDK5RAP2 and PCNT. Interacts with AKAP9; the interaction is leading to Golgi localization of CDK5RAP2 and AKAP9. Interacts with MAPRE1; the interaction is leading to microtubule attachment at plus ends of CDK5RAP2 and MAPRE1. Interacts with TUBG1; the interaction is leading to the centrosomal localization of CDK5RAP2 and TUBG1. Interacts with TUBGCP3. Interacts with CALM1. Interacts with CDC20.
    Function:
    Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends.
    Subcellular Location:
    Cytoplasm cytoskeleton centrosome Golgi apparatus Cytoplasm Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localizes to microtubule plus ends.
    Protein Attributes:
    Sequence length:
    1893
    Sequence:
    50:
    MMDLVLEEDV | TVPGTLSGCS | GLVPSVPDDL | DGINPNAGLG | NGLLPNVSEE | 
    100:
    TVSPTRARNM | KDFENQITEL | KKENFNLKLR | IYFLEERMQQ | EFHGPTEHIY | 
    150:
    KTNIELKVEV | ESLKRELQER | EQLLIKASKA | VESLAEAGGS | EIQRVKEDAR | 
    200:
    KKVQQVEDLL | TKRILLLEKD | VTAAQAELEK | AFAGTETEKA | LRLRLESKLS | 
    250:
    EMKKMHEGDL | AMALVLDEKD | RLIEELKLSL | KSKEALIQCL | KEEKSQMACP | 
    300:
    DENVSSGELR | GLCAAPREEK | ERETEAAQME | HQKERNSFEE | RIQALEEDLR | 
    350:
    EKEREIATEK | KNSLKRDKAI | QGLTMALKSK | EKKVEELNSE | IEKLSAAFAK | 
    400:
    AREALQKAQT | QEFQGSEDYE | TALSGKEALS | AALRSQNLTK | STENHRLRRS | 
    450:
    IKKITQELSD | LQQERERLEK | DLEEAHREKS | KGDCTIRDLR | NEVEKLRNEV | 
    500:
    NEREKAMENR | YKSLLSESNK | KLHNQEQVIK | HLTESTNQKD | VLLQKFNEKD | 
    550:
    LEVIQQNCYL | MAAEDLELRS | EGLITEKCSS | QQPPGSKTIF | SKEKKQSSDY | 
    600:
    EELIQVLKKE | QDIYTHLVKS | LQESDSINNL | QAELNKIFAL | RKQLEQDVLS | 
    650:
    YQNLRKTLEE | QISEIRRREE | ESFSLYSDQT | SYLSICLEEN | NRFQVEHFSQ | 
    700:
    EELKKKVSDL | IQLVKELYTD | NQHLKKTIFD | LSCMGFQGNG | FPDRLASTEQ | 
    750:
    TELLASKEDE | DTIKIGEDDE | INFLSDQHLQ | QSNEIMKDLS | KGGCKNGYLR | 
    800:
    HTESKISDCD | GAHAPGCLEE | GAFINLLAPL | FNEKATLLLE | SRPDLLKVVR | 
    850:
    ELLLGQLFLT | EQEVSGEHLD | GKTEKTPKQK | GELVHFVQTN | SFSKPHDELK | 
    900:
    LSCEAQLVKA | GEVPKVGLKD | ASVQTVATEG | DLLRFKHEAT | REAWEEKPIN | 
    950:
    TALSAEHRPE | NLHGVPGWQA | ALLSLPGITN | REAKKSRLPI | LIKPSRSLGN | 
    1000:
    MYRLPATQEV | VTQLQSQILE | LQGELKEFKT | CNKQLHQKLI | LAEAVMEGRP | 
    1050:
    TPDKTLLNAQ | PPVGAAYQDS | PGEQKGIKTT | SSVWRDKEMD | SDQQRSYEID | 
    1100:
    SEICPPDDLA | SLPSCKENPE | DVLSPTSVAT | YLSSKSQPSA | KVSVMGTDQS | 
    1150:
    ESINTSNETE | YLKQKIHDLE | TELEGYQNFI | FQLQKHSQCS | EAIITVLCGT | 
    1200:
    EGAQDGLSKP | KNGSDGEEMT | FSSLHQVRYV | KHVKILGPLA | PEMIDSRVLE | 
    1250:
    NLKQQLEEQE | YKLQKEQNLN | MQLFSEIHNL | QNKFRDLSPP | RYDSLVQSQA | 
    1300:
    RELSLQRQQI | KDGHGICVIS | RQHMNTMIKA | FEELLQASDV | DYCVAEGFQE | 
    1350:
    QLNQCAELLE | KLEKLFLNGK | SVGVEMNTQN | ELMERIEEDN | LTYQHLLPES | 
    1400:
    PEPSASHALS | DYETSEKSFF | SRDQKQDNET | EKTSVMVNSF | SQDLLMEHIQ | 
    1450:
    EIRTLRKRLE | ESIKTNEKLR | KQLERQGSEF | VQGSTSIFAS | GSELHSSLTS | 
    1500:
    EIHFLRKQNQ | ALNAMLIKGS | RDKQKENDKL | RESLSRKTVS | LEHLQREYAS | 
    1550:
    VKEENERLQK | EGSEKERHNQ | QLIQEVRCSG | QELSRVQEEV | KLRQQLLSQN | 
    1600:
    DKLLQSLRVE | LKAYEKLDEE | HRRLREASGE | GWKGQDPFRD | LHSLLMEIQA | 
    1650:
    LRLQLERSIE | TSSTLQSRLK | EQLARGAEKA | QEGALTLAVQ | AVSIPEVPLQ | 
    1700:
    PDKHDGDKYP | MESDNSFDLF | DSSQAVTPKS | VSETPPLSGN | DTDSLSCDSG | 
    1750:
    SSATSTPCVS | RLVTGHHLWA | SKNGRHVLGL | IEDYEALLKQ | ISQGQRLLAE | 
    1800:
    MDIQTQEAPS | STSQELGTKG | PHPAPLSKFV | SSVSTAKLTL | EEAYRRLKLL | 
    1850:
    WRVSLPEDGQ | CPLHCEQIGE | MKAEVTKLHK | KLFEQEKKLQ | NTMKLLQLSK | 
    1893:
    RQEKVIFDQL | VVTHKILRKA | RGNLELRPGG | AHPGTCSPSR | PGS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human CDK5 regulatory subunit-associated protein 2
    ELISA Kit for Human CDK5 regulatory subunit-associated protein 2
    ELISA Kit for Human CDK5 regulatory subunit-associated protein 2
    CLIA Kit for Human CDK5 regulatory subunit-associated protein 2
    CLIA Kit for Human CDK5 regulatory subunit-associated protein 2
    CLIA Kit for Human CDK5 regulatory subunit-associated protein 2
    Polyclonal Antibody for Human CDK5 regulatory subunit-associated protein 2
    Polyclonal Antibody for Human CDK5 regulatory subunit-associated protein 2
    Polyclonal Antibody for Human CDK5 regulatory subunit-associated protein 2
    Monoclonal Antibody for Human CDK5 regulatory subunit-associated protein 2
    Monoclonal Antibody for Human CDK5 regulatory subunit-associated protein 2
    Monoclonal Antibody for Human CDK5 regulatory subunit-associated protein 2
    Protein for Human CDK5 regulatory subunit-associated protein 2
    Protein for Human CDK5 regulatory subunit-associated protein 2
    Protein for Human CDK5 regulatory subunit-associated protein 2

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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Nakayama M. , Hirosawa M. , Ohara O.
      DNA Res.7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);VARIANT GLN-289
      tissue: Brain.
    2. 2.
      Ohara O. , Nagase T. , Kikuno R.
      Submitted (2005-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      Guo J.H. , Zan Q. , Yu L.
      Submitted (2001-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 575-1893 (ISOFORM 2);VARIANTS GLN-289 AND LEU-1540
      tissue: Amygdala.
      tissue: Retina.
      tissue: Testis.
    5. 5.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 950-1893 (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1576-1654 (ISOFORM 4);VARIANT LEU-1540
      tissue: Kidney.
      tissue: Teratocarcinoma.
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1401-1893
      tissue: Lung.
    8. 8.
      "Cloning of three novel neuronal Cdk5 activator binding proteins."
      Ching Y.-P. , Qi Z. , Wang J.H.
      Gene242:285-294(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    9. 9.
      "Proteomic characterization of the human centrosome by protein correlation profiling."
      Andersen J.S. , Wilkinson C.J. , Mayor T. , Mortensen P. , Nigg E.A. , Mann M.
      Nature426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Lymphoblast.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MCPH3
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    12. 12.
      "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion."
      Graser S. , Stierhof Y.D. , Nigg E.A.
      J. Cell Sci.120:4321-4331(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    13. 13.
      "CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex."
      Fong K.W. , Choi Y.K. , Rattner J.B. , Qi R.Z.
      Mol. Biol. Cell19:115-125(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TUBG1 AND TUBGCP3
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1238 AND SER-1893;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      "CDK5RAP2 is required for spindle checkpoint function."
      Zhang X. , Liu D. , Lv S. , Wang H. , Zhong X. , Liu B. , Wang B. , Liao J. , Li J. , Pfeifer G.P. , Xu X.
      Cell Cycle8:1206-1216(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CDC20
    16. 16.
      "Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics."
      Fong K.W. , Hau S.Y. , Kho Y.S. , Jia Y. , He L. , Qi R.Z.
      Mol. Biol. Cell20:3660-3670(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAPRE1;SUBCELLULAR LOCATION;MUTAGENESIS OF LEU-938 AND PRO-939
    17. 17.
      "Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components."
      Haren L. , Stearns T. , Lueders J.
      PLoS ONE4:E5976-E5976(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    18. 18.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1238;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    19. 19.
      "Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex."
      Wang Z. , Wu T. , Shi L. , Zhang L. , Zheng W. , Qu J.Y. , Niu R. , Qi R.Z.
      J. Biol. Chem.285:22658-22665(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH AKAP9; CALM1 AND PCNT;MUTAGENESIS OF LYS-1865 AND LYS-1869
    20. 20.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-547 AND THR-1001;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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