Cdk5rap2 ELISA Kit for Mouse(Mus musculus) | EIAab.comCdk5rap2 ELISA Kit for Mouse(Mus musculus)

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Cdk5rap2 (Gene name),

CDK5 regulatory subunit-associated protein 2 (Protein name ), CK5P2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cdk5rap2(Kiaa1633);

Protein name:

CDK5 regulatory subunit-associated protein 2;

Alternative:

CDK5 activator-binding protein C48;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5 (By similarity). Interacts with PCNT; the interaction is leading to centrosomal localization of CDK5RAP2 and PCNT. Interacts with AKAP9; the interaction is leading to Golgi localization of CDK5RAP2 and AKAP9 (By similarity). Interacts with TUBG1; the interaction is leading to centrosomal localization of CDK5RAP2 and TUBG1. Interacts with TUBGCP3 (By similarity). Interacts with CALM1 (By similarity). Interacts with CDC20 (By similarity). According to PubMed:19553473, CDK5RAP2 does not interact with MAPRE1.

Function:

Potential regulator of CDK5 activity via its interaction with CDK5R1. Involved in regulation of mitotic spindle orientation (By similarity). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation and brain development.

Subcellular Location:

Cytoplasm cytoskeleton centrosome Golgi apparatus Cytoplasm

Protein Attributes:

Sequence length:

1822

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GNLELRPGAT | RPGASSPSRP | GS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.379344

Pfam:

PF07989

KEGG:

mmu:214444

String:

Q8K389

Uniprot:

Q8K389

FOR

ELISA Kit for Mouse CDK5 regulatory subunit-associated protein 2

CLIA Kit for Mouse CDK5 regulatory subunit-associated protein 2

Polyclonal Antibody for Mouse CDK5 regulatory subunit-associated protein 2

Monoclonal Antibody for Mouse CDK5 regulatory subunit-associated protein 2

Protein for Mouse CDK5 regulatory subunit-associated protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Nagase T. , Ohara O. , Koga H.
DNA Res.10:167-180(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Embryonic tail.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 438-1822
strain: C57BL/6.
tissue: Brain.
4.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
5.

"Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics."
Fong K.W. , Hau S.Y. , Kho Y.S. , Jia Y. , He L. , Qi R.Z.
Mol. Biol. Cell20:3660-3670(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
6.

"CDK5RAP2 regulates centriole engagement and cohesion in mice."
Barrera J.A. , Kao L.R. , Hammer R.E. , Seemann J. , Fuchs J.L. , Megraw T.L.
Dev. Cell18:913-926(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
7.

"Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors."
Lizarraga S.B. , Margossian S.P. , Harris M.H. , Campagna D.R. , Han A.P. , Blevins S. , Mudbhary R. , Barker J.E. , Walsh C.A. , Fleming M.D.
Development137:1907-1917(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
8.

"Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex."
Wang Z. , Wu T. , Shi L. , Zhang L. , Zheng W. , Qu J.Y. , Niu R. , Qi R.Z.
J. Biol. Chem.285:22658-22665(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
9.

"Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex."
Buchman J.J. , Tseng H.C. , Zhou Y. , Frank C.L. , Xie Z. , Tsai L.H.
Neuron66:386-402(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;INTERACTION WITH PCNT

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