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Index > Protein center > CLEC12A(Gene name) > Human
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  • CLEC12A (Gene name),
  • C-type lectin domain family 12 member A (Protein name ),  CL12A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CLEC12A(CLL1;DCAL2;MICL);
    Protein name:
    C-type lectin domain family 12 member A;
    Alternative:
    Dendritic cell-associated lectin 2(DCAL-2);C-type lectin-like molecule 1(CLL-1);Myeloid inhibitory C-type lectin-like receptor(MICL);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PTPN6 and PTPN11.
    Function:
    Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
    Subcellular Location:
    Cell membrane Single-pass type II membrane protein Ligand binding leads to internalization.
    Protein Attributes:
    Sequence length:
    265
    Sequence:
    50:
    MSEEVTYADL | QFQNSSEMEK | IPEIGKFGEK | APPAPSHVWR | PAALFLTLLC | 
    100:
    LLLLIGLGVL | ASMFHVTLKI | EMKKMNKLQN | ISEELQRNIS | LQLMSNMNIS | 
    150:
    NKIRNLSTTL | QTIATKLCRE | LYSKEQEHKC | KPCPRRWIWH | KDSCYFLSDD | 
    200:
    VQTWQESKMA | CAAQNASLLK | INNKNALEFI | KSQSRSYDYW | LGLSPEEDST | 
    250:
    RGMRVDNIIN | SSAWVIRNAP | DLNNMYCGYI | NRLYVQYYHC | TYKKRMICEK | 
    265:
    MANPVQLGST | YFREA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human C-type lectin domain family 12 member A
    Cat.:
    E3690h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human C-type lectin domain family 12 member A
    Cat.:
    E3690m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human C-type lectin domain family 12 member A
    Cat.:
    U3690h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human C-type lectin domain family 12 member A
    Cat.:
    U3690m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human C-type lectin domain family 12 member A
    Cat.:
    P3690Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C-type lectin domain family 12 member A
    Cat.:
    P3690Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human C-type lectin domain family 12 member A
    Monoclonal Antibody for Human C-type lectin domain family 12 member A
    Protein for Human C-type lectin domain family 12 member A
    Protein for Human C-type lectin domain family 12 member A

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Bone marrow.
    2. 2.
      "Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes."
      Marshall A.S.J. , Willment J.A. , Lin H.-H. , Williams D.L. , Gordon S. , Brown G.D.
      J. Biol. Chem.279:14792-14802(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);FUNCTION;INTERACTION WITH PTPN6 AND PTPN11;SUBCELLULAR LOCATION;GLYCOSYLATION;TISSUE SPECIFICITY;VARIANT GLN-244
    3. 3.
      "Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production."
      Chen C.-H. , Floyd H. , Olson N.E. , Magaletti D. , Li C. , Draves K. , Clark E.A.
      Blood107:1459-1467(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANT GLN-244
    4. 4.
      "Novel human C-type lectin superfamily member CLL-1."
      Zhang W. , Wan T. , Chen T. , Cao X.
      Submitted (2000-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT GLN-244
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT GLN-244
      tissue: Lung.
    6. 6.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLN-244
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5);VARIANT GLN-244
      tissue: Blood.
    9. 9.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-98
      tissue: Plasma.
    10. 10.
      "Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation."
      Marshall A.S.J. , Willment J.A. , Pyz E. , Dennehy K.M. , Reid D.M. , Dri P. , Gordon S. , Wong S.Y.C. , Brown G.D.
      Eur. J. Immunol.36:2159-2169(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;INDUCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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