Gene name:
Clasp1 (Kiaa0622) ;
Protein name:
CLIP-associating protein 1 ;
Alternative:
Cytoplasmic linker-associated protein 1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with ERC1, MAPRE1, MAPRE3, microtubules, and PHLDB2. The interaction with ERC1 may be mediated by PHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes (By similarity). Interacts with CLIP2 and RSN. Interacts with MACF1.
Function:
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
Subcellular Location:
Cytoplasm
cytoskeleton
Cytoplasm
cytoskeleton
centrosome
Chromosome
centromere
kinetochore
Cytoplasm
cytoskeleton
spindle
Golgi apparatus
trans-Golgi network
Localizes to microtubule plus ends (By similarity). Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase (By similarity). Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase (By similarity). In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella (By similarity). Localizes to the cell cortex and this requires ERC1 and PHLDB2.
Protein Attributes:
50:
MEPRMESCLA | QVLQKDVGKR | LQVGQELIDY | FSDRQKSADL | EHDQTLLDKL |
100:
VDGLATSWVN | SSNYKVVLLG | MDILSALVTR | LQDRFKAQIG | TVLPSLIDRL |
150:
GDAKDSVREQ | DQTLLLKIMD | QAANPQYVWD | RMLGGFKHKN | FRTREGICLC |
200:
LIATLNASGA | QTLTLSKIVP | HICNLLGDPN | SQVRDAAINS | LVEIYRHVGE |
250:
RVRADLSKKG | LPQSRLNVIF | TKFDEVQKSG | NMIQSANEKN | FDDEDSVDGN |
300:
RPSSASSSSS | KAPSSSRRNV | NLGTTRRLMS | SSLGSKSSAA | KEGAGAVDEE |
350:
DFIKAFDDVP | VVQIYSSRDL | EESINKIREI | LSDDKHDWEQ | RVNALKKIRS |
400:
LLLAGAAEYD | NFFQHLRLLD | GAFKLSAKDL | RSQVVREACI | TLGHLSSVLG |
450:
NKFDHGAEAI | MPTIFNLIPN | SAKIMATSGV | VAVRLIIRHT | HIPRLIPVIT |
500:
SNCTSKSVAV | RRRCFEFLDL | LLQEWQTHSL | ERHISVLAET | IKKGIHDADS |
550:
EARIEARKCY | WGFHSHFSRE | AEHLYHTLES | SYQKALQSHL | KNSDSIVSLP |
600:
QSDRSSSSSQ | ESLNRPLSAK | RSPTGSTASR | GSTVSTKSVS | TTGSLQRSRS |
650:
DIDVNAAASA | KSKVSSSSGS | PAFSSAAALP | PGSYASLGRI | RTRRQSSGST |
700:
TNVASTPDSR | GRSRAKVVSQ | SQRSRSANPA | GAGSRSSSPG | KLLGSGLAGG |
750:
SSRGPPVTPS | SEKRSKIPRS | QGCSRETSPN | RIGLARSSRI | PRPSMSQGCS |
800:
RDTSRESSRD | TSPARGFTPL | DRFGLGQSGR | IPGSVNAMRV | LSTSTDLEAA |
850:
VADALKKPVR | RRYEPYGMYS | DDDANSDASS | VCSERSYGSR | NGGIPHYLRQ |
900:
TEDVAEVLNH | CASSNWSERK | EGLLGLQNLL | KSQRTLSRVE | LKRLCEIFTR |
950:
MFADPHSKRV | FSMFLETLVD | FIIIHKDDLQ | DWLFVLLTQL | LKKMGADLLG |
1000:
SVQAKVQKAL | DVTRDSFPFD | QQFNILMRFI | VDQTQTPNLK | VKVAILKYIE |
1050:
SLARQMDPTD | FVNSSETRLA | VSRIITWTTE | PKSSDVRKAA | QIVLISLFEL |
1100:
NTPEFTMLLG | ALPKTFQDGA | TKLLHNHLKN | SSNTGVGSPS | NTIGRTPSRH |
1150:
PSSRTSPLTS | PTNCSHGGLS | PSRLWGWSAD | GLSKPPPPFS | QPNSIPTAPS |
1200:
HKTLRRSYSP | SMLDYDTENL | NSEEIYSSLR | GVTEAIEKFS | FRSQEDLNEP |
1250:
IKRDGKKDCD | IVSRDGGAAS | PATEGRGGSE | IEGGRMALDN | KTSLLNTQPP |
1300:
RAFPGPRARE | YNPYPYSDTI | NTYDKTALKE | AVFDDDMEQL | RDVPIDHSDL |
1350:
VADLLKELSN | HNERVEERKG | ALLELLKITR | EDSLGVWEEH | FKTILLLLLE |
1400:
TLGDKDHSIR | ALALRVLREI | LRNQPARFKN | YAELTIMKTL | EAHKDSHKEV |
1450:
VRAAEEAAST | LASSIHPEQC | IKVLCPIIQT | ADYPINLAAI | KMQTKVVERI |
1500:
TKESLLQLLV | DIIPGLLQGY | DNTESSVRKA | SVFCLVAIYS | VIGEDLKPHL |
1535:
AQLTGSKMKL | LNLYIKRAQT | TNSNSSSSSD | VSTHS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse CLIP-associating protein 1
ELISA Kit for Mouse CLIP-associating protein 1
CLIA Kit for Mouse CLIP-associating protein 1
CLIA Kit for Mouse CLIP-associating protein 1
Polyclonal Antibody for Mouse CLIP-associating protein 1
Polyclonal Antibody for Mouse CLIP-associating protein 1
Monoclonal Antibody for Mouse CLIP-associating protein 1
Monoclonal Antibody for Mouse CLIP-associating protein 1
Protein for Mouse CLIP-associating protein 1
Protein for Mouse CLIP-associating protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
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Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-393 (ISOFORMS 1/2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1187-1535 (ISOFORMS 1/2)
strain :
C57BL/6J .
tissue :
Embryo .
tissue :
Testis .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 735-1535 (ISOFORM 2)
tissue :
Brain .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 985-1535 (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 997-1535 (ISOFORM 2)
strain :
C57BL/6 .
strain :
FVB/N .
tissue :
Brain .
tissue :
Salivary gland .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic brain .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1220;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Brain .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MACF1