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Index > Protein center > Clasp1(Gene name) > Mouse
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  • Clasp1 (Gene name),
  • CLIP-associating protein 1 (Protein name ),  CLAP1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    Clasp1(Kiaa0622);
    Protein name:
    CLIP-associating protein 1;
    Alternative:
    Cytoplasmic linker-associated protein 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with ERC1, MAPRE1, MAPRE3, microtubules, and PHLDB2. The interaction with ERC1 may be mediated by PHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes (By similarity). Interacts with CLIP2 and RSN. Interacts with MACF1.
    Function:
    Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
    Subcellular Location:
    Cytoplasm cytoskeleton Cytoplasm cytoskeleton centrosome Chromosome centromere kinetochore Cytoplasm cytoskeleton spindle Golgi apparatus trans-Golgi network Localizes to microtubule plus ends (By similarity). Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase (By similarity). Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase (By similarity). In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella (By similarity). Localizes to the cell cortex and this requires ERC1 and PHLDB2.
    Protein Attributes:
    Sequence length:
    1535
    Sequence:
    50:
    MEPRMESCLA | QVLQKDVGKR | LQVGQELIDY | FSDRQKSADL | EHDQTLLDKL | 
    100:
    VDGLATSWVN | SSNYKVVLLG | MDILSALVTR | LQDRFKAQIG | TVLPSLIDRL | 
    150:
    GDAKDSVREQ | DQTLLLKIMD | QAANPQYVWD | RMLGGFKHKN | FRTREGICLC | 
    200:
    LIATLNASGA | QTLTLSKIVP | HICNLLGDPN | SQVRDAAINS | LVEIYRHVGE | 
    250:
    RVRADLSKKG | LPQSRLNVIF | TKFDEVQKSG | NMIQSANEKN | FDDEDSVDGN | 
    300:
    RPSSASSSSS | KAPSSSRRNV | NLGTTRRLMS | SSLGSKSSAA | KEGAGAVDEE | 
    350:
    DFIKAFDDVP | VVQIYSSRDL | EESINKIREI | LSDDKHDWEQ | RVNALKKIRS | 
    400:
    LLLAGAAEYD | NFFQHLRLLD | GAFKLSAKDL | RSQVVREACI | TLGHLSSVLG | 
    450:
    NKFDHGAEAI | MPTIFNLIPN | SAKIMATSGV | VAVRLIIRHT | HIPRLIPVIT | 
    500:
    SNCTSKSVAV | RRRCFEFLDL | LLQEWQTHSL | ERHISVLAET | IKKGIHDADS | 
    550:
    EARIEARKCY | WGFHSHFSRE | AEHLYHTLES | SYQKALQSHL | KNSDSIVSLP | 
    600:
    QSDRSSSSSQ | ESLNRPLSAK | RSPTGSTASR | GSTVSTKSVS | TTGSLQRSRS | 
    650:
    DIDVNAAASA | KSKVSSSSGS | PAFSSAAALP | PGSYASLGRI | RTRRQSSGST | 
    700:
    TNVASTPDSR | GRSRAKVVSQ | SQRSRSANPA | GAGSRSSSPG | KLLGSGLAGG | 
    750:
    SSRGPPVTPS | SEKRSKIPRS | QGCSRETSPN | RIGLARSSRI | PRPSMSQGCS | 
    800:
    RDTSRESSRD | TSPARGFTPL | DRFGLGQSGR | IPGSVNAMRV | LSTSTDLEAA | 
    850:
    VADALKKPVR | RRYEPYGMYS | DDDANSDASS | VCSERSYGSR | NGGIPHYLRQ | 
    900:
    TEDVAEVLNH | CASSNWSERK | EGLLGLQNLL | KSQRTLSRVE | LKRLCEIFTR | 
    950:
    MFADPHSKRV | FSMFLETLVD | FIIIHKDDLQ | DWLFVLLTQL | LKKMGADLLG | 
    1000:
    SVQAKVQKAL | DVTRDSFPFD | QQFNILMRFI | VDQTQTPNLK | VKVAILKYIE | 
    1050:
    SLARQMDPTD | FVNSSETRLA | VSRIITWTTE | PKSSDVRKAA | QIVLISLFEL | 
    1100:
    NTPEFTMLLG | ALPKTFQDGA | TKLLHNHLKN | SSNTGVGSPS | NTIGRTPSRH | 
    1150:
    PSSRTSPLTS | PTNCSHGGLS | PSRLWGWSAD | GLSKPPPPFS | QPNSIPTAPS | 
    1200:
    HKTLRRSYSP | SMLDYDTENL | NSEEIYSSLR | GVTEAIEKFS | FRSQEDLNEP | 
    1250:
    IKRDGKKDCD | IVSRDGGAAS | PATEGRGGSE | IEGGRMALDN | KTSLLNTQPP | 
    1300:
    RAFPGPRARE | YNPYPYSDTI | NTYDKTALKE | AVFDDDMEQL | RDVPIDHSDL | 
    1350:
    VADLLKELSN | HNERVEERKG | ALLELLKITR | EDSLGVWEEH | FKTILLLLLE | 
    1400:
    TLGDKDHSIR | ALALRVLREI | LRNQPARFKN | YAELTIMKTL | EAHKDSHKEV | 
    1450:
    VRAAEEAAST | LASSIHPEQC | IKVLCPIIQT | ADYPINLAAI | KMQTKVVERI | 
    1500:
    TKESLLQLLV | DIIPGLLQGY | DNTESSVRKA | SVFCLVAIYS | VIGEDLKPHL | 
    1535:
    AQLTGSKMKL | LNLYIKRAQT | TNSNSSSSSD | VSTHS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CLIP-associating protein 1
    ELISA Kit for Mouse CLIP-associating protein 1
    CLIA Kit for Mouse CLIP-associating protein 1
    CLIA Kit for Mouse CLIP-associating protein 1
    Polyclonal Antibody for Mouse CLIP-associating protein 1
    Polyclonal Antibody for Mouse CLIP-associating protein 1
    Monoclonal Antibody for Mouse CLIP-associating protein 1
    Monoclonal Antibody for Mouse CLIP-associating protein 1
    Protein for Mouse CLIP-associating protein 1
    Protein for Mouse CLIP-associating protein 1

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts."
      Akhmanova A. , Hoogenraad C.C. , Drabek K. , Stepanova T. , Dortland B. , Verkerk T. , Vermeulen W. , Burgering B.M. , de Zeeuw C.I. , Grosveld F. , Galjart N.
      Cell104:923-935(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-306 (ISOFORMS 1/2);NUCLEOTIDE SEQUENCE [MRNA] OF 1251-1535 (ISOFORMS 1/2);INTERACTION WITH CLIP2 AND RSN;TISSUE SPECIFICITY
      tissue: Brain.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-393 (ISOFORMS 1/2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1187-1535 (ISOFORMS 1/2)
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Testis.
    4. 4.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Aizawa H. , Yuasa S. , Nakajima D. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 735-1535 (ISOFORM 2)
      tissue: Brain.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 985-1535 (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 997-1535 (ISOFORM 2)
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Brain.
      tissue: Salivary gland.
    6. 6.
      "Phosphoproteomic analysis of the developing mouse brain."
      Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
      Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic brain.
    7. 7.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1220;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    8. 8.
      "ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity."
      Wu X. , Kodama A. , Fuchs E.
      Cell135:137-148(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MACF1
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