Gene name:
CLEC5A (CLECSF5;MDL1) ;
Protein name:
C-type lectin domain family 5 member A ;
Alternative:
Myeloid DAP12-associating lectin 1 (MDL-1) ;C-type lectin superfamily member 5 ;
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Monomer (By similarity). Homodimer (By similarity). The majority of CLEC5A is expressed as a monomeric form on macrophages (By similarity). Interacts with TYROBP/DAP12 (By similarity). The interaction with TYROBP is required for CLEC5 cell surface expression (By similarity). Interacts with HCST/DAP10 (By similarity). Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP.
Function:
Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation.
Subcellular Location:
Cell membrane
Single-pass type II membrane protein
Protein Attributes:
50:
MNWHMIISGL | IVVVLKIVGM | TFFLLYFPQI | FGEHNVSFSP | TERPGTVPQI |
100:
FGSSNVSFTP | TESFGTVCPT | GWDFHQGRCF | FLSTSENSWN | NSMNFCKQKG |
150:
STLAIVNTPE | KLKFLQNISG | AEKYFIGLLY | QPAEKMWRWI | NNSVFNGSVI |
185:
SHSHNFNCVT | IGLTKTFDAA | SCDVNYRSIC | EKSAQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Pig
Human
ELISA Kit for Pig C-type lectin domain family 5 member A
ELISA Kit for Pig C-type lectin domain family 5 member A
ELISA Kit for Pig C-type lectin domain family 5 member A
CLIA Kit for Pig C-type lectin domain family 5 member A
CLIA Kit for Pig C-type lectin domain family 5 member A
CLIA Kit for Pig C-type lectin domain family 5 member A
Polyclonal Antibody for Pig C-type lectin domain family 5 member A
Polyclonal Antibody for Pig C-type lectin domain family 5 member A
Polyclonal Antibody for Pig C-type lectin domain family 5 member A
Monoclonal Antibody for Pig C-type lectin domain family 5 member A
Monoclonal Antibody for Pig C-type lectin domain family 5 member A
Monoclonal Antibody for Pig C-type lectin domain family 5 member A
Protein for Pig C-type lectin domain family 5 member A
Protein for Pig C-type lectin domain family 5 member A
Protein for Pig C-type lectin domain family 5 member A
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH TYROBP