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Index > Protein center > CLCA1(Gene name) > Human
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  • CLCA1 (Gene name),
  • Calcium-activated chloride channel regulator 1 (Protein name ),  CLCA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CLCA1(CACC1);
    Protein name:
    Calcium-activated chloride channel regulator 1;
    Alternative:
    Calcium-activated chloride channel protein 1(CaCC-1;hCaCC-1);Calcium-activated chloride channel family member 1(hCLCA1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
    Subcellular Location:
    Secreted extracellular space Cell membrane Peripheral membrane protein Extracellular side Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
    Protein Attributes:
    Sequence length:
    914
    Sequence:
    50:
    MGPFKSSVFI | LILHLLEGAL | SNSLIQLNNN | GYEGIVVAID | PNVPEDETLI | 
    100:
    QQIKDMVTQA | SLYLLEATGK | RFYFKNVAIL | IPETWKTKAD | YVRPKLETYK | 
    150:
    NADVLVAEST | PPGNDEPYTE | QMGNCGEKGE | RIHLTPDFIA | GKKLAEYGPQ | 
    200:
    GRAFVHEWAH | LRWGVFDEYN | NDEKFYLSNG | RIQAVRCSAG | ITGTNVVKKC | 
    250:
    QGGSCYTKRC | TFNKVTGLYE | KGCEFVLQSR | QTEKASIMFA | QHVDSIVEFC | 
    300:
    TEQNHNKEAP | NKQNQKCNLR | STWEVIRDSE | DFKKTTPMTT | QPPNPTFSLL | 
    350:
    QIGQRIVCLV | LDKSGSMATG | NRLNRLNQAG | QLFLLQTVEL | GSWVGMVTFD | 
    400:
    SAAHVQNELI | QINSGSDRDT | LAKRLPAAAS | GGTSICSGLR | SAFTVIRKKY | 
    450:
    PTDGSEIVLL | TDGEDNTISG | CFNEVKQSGA | IIHTVALGPS | AAQELEELSK | 
    500:
    MTGGLQTYAS | DQVQNNGLID | AFGALSSGNG | AVSQRSIQLE | SKGLTLQNSQ | 
    550:
    WMNGTVIVDS | TVGKDTLFLI | TWTMQPPQIL | LWDPSGQKQG | GFVVDKNTKM | 
    600:
    AYLQIPGIAK | VGTWKYSLQA | SSQTLTLTVT | SRASNATLPP | ITVTSKTNKD | 
    650:
    TSKFPSPLVV | YANIRQGASP | ILRASVTALI | ESVNGKTVTL | ELLDNGAGAD | 
    700:
    ATKDDGVYSR | YFTTYDTNGR | YSVKVRALGG | VNAARRRVIP | QQSGALYIPG | 
    750:
    WIENDEIQWN | PPRPEINKDD | VQHKQVCFSR | TSSGGSFVAS | DVPNAPIPDL | 
    800:
    FPPGQITDLK | AEIHGGSLIN | LTWTAPGDDY | DHGTAHKYII | RISTSILDLR | 
    850:
    DKFNESLQVN | TTALIPKEAN | SEEVFLFKPE | NITFENGTDL | FIAIQAVDKV | 
    900:
    DLKSEISNIA | RVSLFIPPQT | PPETPSPDET | SAPCPNIHIN | STIPGIHILK | 
    914:
    IMWKWIGELQ | LSIA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Calcium-activated chloride channel regulator 1
    ELISA Kit for Human Calcium-activated chloride channel regulator 1
    ELISA Kit for Human Calcium-activated chloride channel regulator 1
    CLIA Kit for Human Calcium-activated chloride channel regulator 1
    CLIA Kit for Human Calcium-activated chloride channel regulator 1
    CLIA Kit for Human Calcium-activated chloride channel regulator 1
    Polyclonal Antibody for Human Calcium-activated chloride channel regulator 1
    Polyclonal Antibody for Human Calcium-activated chloride channel regulator 1
    Polyclonal Antibody for Human Calcium-activated chloride channel regulator 1
    Monoclonal Antibody for Human Calcium-activated chloride channel regulator 1
    Monoclonal Antibody for Human Calcium-activated chloride channel regulator 1
    Monoclonal Antibody for Human Calcium-activated chloride channel regulator 1
    Protein for Human Calcium-activated chloride channel regulator 1
    Protein for Human Calcium-activated chloride channel regulator 1
    Protein for Human Calcium-activated chloride channel regulator 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins."
      Gruber A.D. , Elble R.C. , Ji H.-L. , Schreur K.D. , Fuller C.M. , Pauli B.U.
      Genomics54:200-214(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];FUNCTION;TISSUE SPECIFICITY;GLYCOSYLATION;PROTEOLYTIC PROCESSING;VARIANTS PHE-65; LYS-152; SER-357; THR-524 AND ASN-760
      tissue: Small intestine.
    2. 2.
      "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea."
      Agnel M. , Vermat T. , Culouscou J.-M.
      FEBS Lett.455:295-301(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;VARIANTS PHE-65; SER-357 AND THR-524
      tissue: Small intestine.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS PHE-65; SER-357 AND THR-524
      tissue: Colon.
      tissue: Small intestine.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS PHE-65; SER-357 AND THR-524
    6. 6.
      "Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation."
      Yurtsever Z. , Sala-Rabanal M. , Randolph D.T. , Scheaffer S.M. , Roswit W.T. , Alevy Y.G. , Patel A.C. , Heier R.F. , Romero A.G. , Nichols C.G. , Holtzman M.J. , Brett T.J.
      J. Biol. Chem.287:42138-42149(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 695-699;FUNCTION;METALLOPROTEASE DOMAIN;PROTEOLYTIC PROCESSING;MUTAGENESIS OF HIS-156 AND GLU-157
    7. 7.
      "Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer."
      Bustin S.A. , Li S.-R. , Dorudi S.
      DNA Cell Biol.20:331-338(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    8. 8.
      "Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway."
      Hoshino M. , Morita S. , Iwashita H. , Sagiya Y. , Nagi T. , Nakanishi A. , Ashida Y. , Nishimura O. , Fujisawa Y. , Fujino M.
      Am. J. Respir. Crit. Care Med.165:1132-1136(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;TISSUE SPECIFICITY
    9. 9.
      "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma."
      Toda M. , Tulic M.K. , Levitt R.C. , Hamid Q.
      J. Allergy Clin. Immunol.109:246-250(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;TISSUE SPECIFICITY
    10. 10.
      "Expression and distribution of ion transport mRNAs in human nasal mucosa and nasal polyps."
      Lee S.H. , Park J.H. , Jung H.H. , Lee S.H. , Oh J.W. , Lee H.M. , Jun H.S. , Cho W.J. , Lee J.Y.
      Acta Oto-Laryngol.125:745-752(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
    11. 11.
      "Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa."
      Hauber H.-P. , Daigneault P. , Frenkiel S. , Lavigne F. , Hung H.-L. , Levitt R.C. , Hamid Q.
      J. Allergy Clin. Immunol.115:266-271(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    12. 12.
      "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels."
      Gibson A. , Lewis A.P. , Affleck K. , Aitken A.J. , Meldrum E. , Thompson N.
      J. Biol. Chem.280:27205-27212(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    13. 13.
      "Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium."
      Thai P. , Chen Y. , Dolganov G. , Wu R.
      Am. J. Respir. Cell Mol. Biol.33:523-530(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    14. 14.
      "Histamine induces MUC5AC expression via a hCLCA1 pathway."
      Kim Y.M. , Won T.-B. , Kim S.W. , Min Y.-G. , Lee C.H. , Rhee C.-S.
      Pharmacology80:219-226(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
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