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Index > Protein center > Clca1(Gene name) > Mouse
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  • Clca1 (Gene name),
  • Calcium-activated chloride channel regulator 1 (Protein name ),  CLCA1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Clca1(Clca3;Gob5);
    Protein name:
    Calcium-activated chloride channel regulator 1;
    Alternative:
    Protein gob-5;Calcium-activated chloride channel family member 3(mCLCA3);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
    Subcellular Location:
    Secreted extracellular space The 75 kDa N-terminal and a 35 kDa C-terminal products are fully secreted into extracellular environment as a soluble complex of two glycoproteins.
    Protein Attributes:
    Sequence length:
    913
    Sequence:
    50:
    MESLKSPVFL | LILHLLEGVL | SESLIQLNNN | GYEGIVIAID | HDVPEDEALI | 
    100:
    QHIKDMVTQA | SPYLFEATGK | RFYFKNVAIL | IPESWKAKPE | YTRPKLETFK | 
    150:
    NADVLVSTTS | PLGNDEPYTE | HIGACGEKGI | RIHLTPDFLA | GKKLTQYGPQ | 
    200:
    DRTFVHEWAH | FRWGVFNEYN | NDEKFYLSKG | KPQAVRCSAA | ITGKNQVRRC | 
    250:
    QGGSCITNGK | CVIDRVTGLY | KDNCVFVPDP | HQNEKASIMF | NQNINSVVEF | 
    300:
    CTEKNHNQEA | PNDQNQRCNL | RSTWEVIQES | EDFKQTTPMT | AQPPAPTFSL | 
    350:
    LQIGQRIVCL | VLDKSGSMLN | DDRLNRMNQA | SRLFLLQTVE | QGSWVGMVTF | 
    400:
    DSAAYVQSEL | KQLNSGADRD | LLIKHLPTVS | AGGTSICSGL | RTAFTVIKKK | 
    450:
    YPTDGSEIVL | LTDGEDNTIS | SCFDLVKQSG | AIIHTVALGP | AAAKELEQLS | 
    500:
    KMTGGLQTYS | SDQVQNNGLV | DAFAALSSGN | AAIAQHSIQL | ESRGVNLQNN | 
    550:
    QWMNGSVIVD | SSVGKDTLFL | ITWTTHPPTI | FIWDPSGVEQ | NGFILDTTTK | 
    600:
    VAYLQVPGTA | KVGFWKYSIQ | ASSQTLTLTV | TSRAASATLP | PITVTPVVNK | 
    650:
    NTGKFPSPVT | VYASIRQGAS | PILRASVTAL | IESVNGKTVT | LELLDNGAGA | 
    700:
    DATKNDGVYS | RFFTAFDANG | RYSVKIWALG | GVTSDRQRAA | PPKNRAMYID | 
    750:
    GWIEDGEVRM | NPPRPETSYV | QDKQLCFSRT | SSGGSFVATN | VPAAAPIPDL | 
    800:
    FPPCQITDLK | ASIQGQNLVN | LTWTAPGDDY | DHGRASNYII | RMSTSIVDLR | 
    850:
    DHFNTSLQVN | TTGLIPKEAS | SEEIFEFELG | GNTFGNGTDI | FIAIQAVDKS | 
    900:
    NLKSEISNIA | RVSVFIPAQE | PPIPEDSTPP | CPDISINSTI | PGIHVLKIMW | 
    913:
    KWLGEMQVTL | GLH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Calcium-activated chloride channel regulator 1
    ELISA Kit for Mouse Calcium-activated chloride channel regulator 1
    ELISA Kit for Mouse Calcium-activated chloride channel regulator 1
    CLIA Kit for Mouse Calcium-activated chloride channel regulator 1
    CLIA Kit for Mouse Calcium-activated chloride channel regulator 1
    CLIA Kit for Mouse Calcium-activated chloride channel regulator 1
    Polyclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
    Polyclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
    Polyclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
    Monoclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
    Monoclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
    Monoclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
    Protein for Mouse Calcium-activated chloride channel regulator 1
    Protein for Mouse Calcium-activated chloride channel regulator 1
    Protein for Mouse Calcium-activated chloride channel regulator 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and identification of the gene gob-5, which is expressed in intestinal goblet cells in mice."
      Komiya T. , Tanigawa Y. , Hirohashi S.
      Biochem. Biophys. Res. Commun.255:347-351(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Intestine.
    2. 2.
      "Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma."
      Zhou Y. , Dong Q. , Louahed J. , Dragwa C. , Savio D. , Huang M. , Weiss C. , Tomer Y. , McLane M.P. , Nicolaides N.C. , Levitt R.C.
      Am. J. Respir. Cell Mol. Biol.25:486-491(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INDUCTION
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Colon.
      tissue: Stomach.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Colon.
    5. 5.
      "Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma."
      Nakanishi A. , Morita S. , Iwashita H. , Sagiya Y. , Ashida Y. , Shirafuji H. , Fujisawa Y. , Nishimura O. , Fujino M.
      Proc. Natl. Acad. Sci. U.S.A.98:5175-5180(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    6. 6.
      "The murine mCLCA3 (alias gob-5) protein is located in the mucin granule membranes of intestinal, respiratory, and uterine goblet cells."
      Leverkoehne I. , Gruber A.D.
      J. Histochem. Cytochem.50:829-838(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PROTEOLYTIC PROCESSING;GLYCOSYLATION
    7. 7.
      "Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis."
      Sabo-Attwood T. , Ramos-Nino M. , Bond J. , Butnor K.J. , Heintz N. , Gruber A.D. , Steele C. , Taatjes D.J. , Vacek P. , Mossman B.T.
      Am. J. Pathol.167:1243-1256(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    8. 8.
      "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels."
      Gibson A. , Lewis A.P. , Affleck K. , Aitken A.J. , Meldrum E. , Thompson N.
      J. Biol. Chem.280:27205-27212(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 9.
      "Blue native/SDS-PAGE analysis reveals reduced expression of the mClCA3 protein in cystic fibrosis knock-out mice."
      Brouillard F. , Bensalem N. , Hinzpeter A. , Tondelier D. , Trudel S. , Gruber A.D. , Ollero M. , Edelman A.
      Mol. Cell. Proteomics4:1762-1775(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    10. 10.
      "Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation."
      Long A.J. , Sypek J.P. , Askew R. , Fish S.C. , Mason L.E. , Williams C.M.M. , Goldman S.J.
      Am. J. Respir. Cell Mol. Biol.35:357-365(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    11. 11.
      "Both cleavage products of the mCLCA3 protein are secreted soluble proteins."
      Mundhenk L. , Alfalah M. , Elble R.C. , Pauli B.U. , Naim H.Y. , Gruber A.D.
      J. Biol. Chem.281:30072-30080(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;GLYCOSYLATION;PROCESSING
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