Gene name:
Clca1 (Clca3;Gob5) ;
Protein name:
Calcium-activated chloride channel regulator 1 ;
Alternative:
Protein gob-5 ;Calcium-activated chloride channel family member 3 (mCLCA3) ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Subcellular Location:
Secreted
extracellular space
The 75 kDa N-terminal and a 35 kDa C-terminal products are fully secreted into extracellular environment as a soluble complex of two glycoproteins.
Protein Attributes:
50:
MESLKSPVFL | LILHLLEGVL | SESLIQLNNN | GYEGIVIAID | HDVPEDEALI |
100:
QHIKDMVTQA | SPYLFEATGK | RFYFKNVAIL | IPESWKAKPE | YTRPKLETFK |
150:
NADVLVSTTS | PLGNDEPYTE | HIGACGEKGI | RIHLTPDFLA | GKKLTQYGPQ |
200:
DRTFVHEWAH | FRWGVFNEYN | NDEKFYLSKG | KPQAVRCSAA | ITGKNQVRRC |
250:
QGGSCITNGK | CVIDRVTGLY | KDNCVFVPDP | HQNEKASIMF | NQNINSVVEF |
300:
CTEKNHNQEA | PNDQNQRCNL | RSTWEVIQES | EDFKQTTPMT | AQPPAPTFSL |
350:
LQIGQRIVCL | VLDKSGSMLN | DDRLNRMNQA | SRLFLLQTVE | QGSWVGMVTF |
400:
DSAAYVQSEL | KQLNSGADRD | LLIKHLPTVS | AGGTSICSGL | RTAFTVIKKK |
450:
YPTDGSEIVL | LTDGEDNTIS | SCFDLVKQSG | AIIHTVALGP | AAAKELEQLS |
500:
KMTGGLQTYS | SDQVQNNGLV | DAFAALSSGN | AAIAQHSIQL | ESRGVNLQNN |
550:
QWMNGSVIVD | SSVGKDTLFL | ITWTTHPPTI | FIWDPSGVEQ | NGFILDTTTK |
600:
VAYLQVPGTA | KVGFWKYSIQ | ASSQTLTLTV | TSRAASATLP | PITVTPVVNK |
650:
NTGKFPSPVT | VYASIRQGAS | PILRASVTAL | IESVNGKTVT | LELLDNGAGA |
700:
DATKNDGVYS | RFFTAFDANG | RYSVKIWALG | GVTSDRQRAA | PPKNRAMYID |
750:
GWIEDGEVRM | NPPRPETSYV | QDKQLCFSRT | SSGGSFVATN | VPAAAPIPDL |
800:
FPPCQITDLK | ASIQGQNLVN | LTWTAPGDDY | DHGRASNYII | RMSTSIVDLR |
850:
DHFNTSLQVN | TTGLIPKEAS | SEEIFEFELG | GNTFGNGTDI | FIAIQAVDKS |
900:
NLKSEISNIA | RVSVFIPAQE | PPIPEDSTPP | CPDISINSTI | PGIHVLKIMW |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Human
Mouse
ELISA Kit for Mouse Calcium-activated chloride channel regulator 1
ELISA Kit for Mouse Calcium-activated chloride channel regulator 1
ELISA Kit for Mouse Calcium-activated chloride channel regulator 1
CLIA Kit for Mouse Calcium-activated chloride channel regulator 1
CLIA Kit for Mouse Calcium-activated chloride channel regulator 1
CLIA Kit for Mouse Calcium-activated chloride channel regulator 1
Polyclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
Polyclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
Polyclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
Monoclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
Monoclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
Monoclonal Antibody for Mouse Calcium-activated chloride channel regulator 1
Protein for Mouse Calcium-activated chloride channel regulator 1
Protein for Mouse Calcium-activated chloride channel regulator 1
Protein for Mouse Calcium-activated chloride channel regulator 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Intestine .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INDUCTION
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Colon .
tissue :
Stomach .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Colon .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PROTEOLYTIC PROCESSING;GLYCOSYLATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;GLYCOSYLATION;PROCESSING