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Soubrier F. , Alhenc-Gelas F. , Hubert C. , Allegrini J. , John M. , Tregear G. , Corbol P.
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"The testicular transcript of the angiotensin I-converting enzyme encodes for the ancestral, non-duplicated form of the enzyme."
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"Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme."
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"Sequence variation in the human angiotensin converting enzyme."
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

NHLBI resequencing and genotyping service (RS&G)
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , Chen C.-K. , Cook A. , Corum B. , Cuomo C.A. , de Jong P.J. , DeCaprio D. , Dewar K. , FitzGerald M. , Gilbert J. , Gibson R. , Gnerre S. , Goldstein S. , Grafham D.V. , Grocock R. , Hafez N. , Hagopian D.S. , Hart E. , Norman C.H. , Humphray S. , Jaffe D.B. , Jones M. , Kamal M. , Khodiyar V.K. , LaButti K. , Laird G. , Lehoczky J. , Liu X. , Lokyitsang T. , Loveland J. , Lui A. , Macdonald P. , Major J.E. , Matthews L. , Mauceli E. , McCarroll S.A. , Mihalev A.H. , Mudge J. , Nguyen C. , Nicol R. , O'Leary S.B. , Osoegawa K. , Schwartz D.C. , Shaw-Smith C. , Stankiewicz P. , Steward C. , Swarbreck D. , Venkataraman V. , Whittaker C.A. , Yang X. , Zimmer A.R. , Bradley A. , Hubbard T. , Birren B.W. , Rogers J. , Lander E.S. , Nusbaum C. more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"Purification of human lung angiotensin-converting enzyme by high-performance liquid chromatography: properties and N-terminal amino acid sequence."
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J. Biochem.106:442-445(1989) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing of the mRNA coding for the human endothelial angiotensin-converting enzyme: a new mechanism for solubilization."
Sugimura K. , Tian X.-L. , Hoffmann S. , Ganten D. , Bader M.
Biochem. Biophys. Res. Commun.247:466-472(1998) [PubMed] [Europe PMC] [Abstract]

"Angiotensin-converting enzyme: zinc- and inhibitor-binding stoichiometries of the somatic and testis isozymes."
Ehlers M.R.W. , Riordan J.F.
Biochemistry30:7118-7126(1991) [PubMed] [Europe PMC] [Abstract]

"Assignment of free and disulfide-bonded cysteine residues in testis angiotensin-converting enzyme: functional implications."
Sturrock E.D. , Yu X.C. , Wu Z. , Biemann K. , Riordan J.F.
Biochemistry35:9560-9566(1996) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycosylation sites in human testis angiotensin-converting enzyme and expression of an active deglycosylated form."
Yu X.C. , Sturrock E.D. , Wu Z. , Biemann K. , Ehlers M.R.W. , Riordan J.F.
J. Biol. Chem.272:3511-3519(1997) [PubMed] [Europe PMC] [Abstract]

"Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites."
Woodman Z.L. , Oppong S.Y. , Cook S. , Hooper N.M. , Schwager S.L.U. , Brandt W.F. , Ehlers M.R.W. , Sturrock E.D.
Biochem. J.347:711-718(2000) [PubMed] [Europe PMC] [Abstract]

"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9."
Donoghue M. , Hsieh F. , Baronas E. , Godbout K. , Gosselin M. , Stagliano N. , Donovan M. , Woolf B. , Robison K. , Jeyaseelan R. , Breitbart R.E. , Acton S.
Circ. Res.87:E1-E9(2000) [PubMed] [Europe PMC] [Abstract]

"A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase."
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J. Biol. Chem.275:33238-33243(2000) [PubMed] [Europe PMC] [Abstract]

"Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region."
Eyries M. , Michaud A. , Deinum J. , Agrapart M. , Chomilier J. , Kramers C. , Soubrier F.
J. Biol. Chem.276:5525-5532(2001) [PubMed] [Europe PMC] [Abstract]

"CK2 phosphorylates the angiotensin-converting enzyme and regulates its retention in the endothelial cell plasma membrane."
Kohlstedt K. , Shoghi F. , Mueller-Esterl W. , Busse R. , Fleming I.
Circ. Res.91:749-756(2002) [PubMed] [Europe PMC] [Abstract]

"Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme."
Harmer D. , Gilbert M. , Borman R. , Clark K.L.
FEBS Lett.532:107-110(2002) [PubMed] [Europe PMC] [Abstract]

"Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme."
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Biochem. J.371:437-442(2003) [PubMed] [Europe PMC] [Abstract]

"ACE2 gene expression is up-regulated in the human failing heart."
Goulter A.B. , Goddard M.J. , Allen J.C. , Clark K.L.
BMC Med.2:19-19(2004) [PubMed] [Europe PMC] [Abstract]

"Myocardial infarction increases ACE2 expression in rat and humans."
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"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
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"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
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"Initial characterization of the human central proteome."
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"Crystal structure of the human angiotensin-converting enzyme-lisinopril complex."
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"Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme."
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"Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design."
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"The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM."
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"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
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"Point mutation in the stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-converting enzyme but no cardiovascular disease."
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"Hereditary elevation of angiotensin converting enzyme suggesting neurosarcoidosis."
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"Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls."
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"DD genotype of ACE gene is a risk factor for intracerebral hemorrhage."
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Neurology63:359-361(2004) [PubMed] [Europe PMC] [Abstract]

"Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis."
Gribouval O. , Gonzales M. , Neuhaus T. , Aziza J. , Bieth E. , Laurent N. , Bouton J.M. , Feuillet F. , Makni S. , Ben Amar H. , Laube G. , Delezoide A.-L. , Bouvier R. , Dijoud F. , Ollagnon-Roman E. , Roume J. , Joubert M. , Antignac C. , Gubler M.-C. more...
Nat. Genet.37:964-968(2005) [PubMed] [Europe PMC] [Abstract]