Protein name:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 ;
Alternative:
Protein JTV-1 ;Multisynthase complex auxiliary component p38 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PARK2/parkin (via first RING-type domain).
Function:
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Subcellular Location:
Cytoplasm
cytosol
Nucleus
Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
Protein Attributes:
50:
MPMYQVKPYH | EGSGSLRVEL | PTCMYRLPNV | HGRTGSPAPS | ADHVQEASDP |
100:
SLQALESHQD | DILKRLYELK | AAVDGLSKMI | QTPDADLDVT | NIIQADEPAA |
150:
LSTSTVDLNA | MLGQDHGALK | DIVINANPAS | PPLSLLVLHR | LLCDHYKVLS |
200:
SVHTHSAVRS | VPANLLQCFG | EQTRQQPRHE | YQLGFTLIWK | DVPKTQMKFS |
250:
VQTMCPIEGE | GNIARFLFSL | FGQKQDAVNL | TLIDSWVDIA | IFQLKEGSSK |
300:
EKAAVFRSMN | SALGKTPWLV | GDELTVADVV | LWSVLRQTGG | CGGMAPANVQ |
320:
KWMQACENLA | PFHTALKLLQ |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
ELISA Kit for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
ELISA Kit for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
ELISA Kit for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
ELISA Kit for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
CLIA Kit for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
CLIA Kit for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
CLIA Kit for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
CLIA Kit for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Polyclonal Antibody for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Polyclonal Antibody for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Polyclonal Antibody for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Polyclonal Antibody for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Monoclonal Antibody for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Monoclonal Antibody for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Monoclonal Antibody for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Monoclonal Antibody for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Protein for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Protein for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Protein for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Protein for Bovine Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Hypothalamus .