Apaf1 CLIA Kit for Mouse(Mus musculus) | EIAab.comApaf1 CLIA Kit for Mouse(Mus musculus)

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Apaf1 (Gene name),

Apoptotic protease-activating factor 1 (Protein name ), APAF_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Apaf1;

Protein name:

Apoptotic protease-activating factor 1(APAF-1);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer. Oligomerizes upon binding of cytochrome c and dATP. Oligomeric Apaf-1 and pro-caspase-9 bind to each other via their respective NH2-terminal CARD domains and consecutively mature caspase-9 is released from the complex (By similarity). Interacts with UACA. It may also interact with Bcl-XL. Interacts with APIP.

Function:

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase 9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1249

Sequence:

50:

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1050:

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1150:

1200:

1249:

KWWNVATGDS | SQTFYTNGTN | LKKIHVSPDF | RTYVTVDNLG | ILYILQVLE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O88879

String:

O88879

UniGene:

Mm.220289

Pfam:

PF00619

KEGG:

mmu:11783

Uniprot:

O88879

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ELISA Kit for Mouse APAF-1

Cat.:

E1054m

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96T

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ELISA Kit for Mouse APAF-1

Cat.:

E1054r

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96T

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ELISA Kit for Mouse APAF-1

Cat.:

E1054h

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MSDS:

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96T

ELISA Kit for Mouse APAF-1

Cat.:

E1054d

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MSDS:

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96T

CLIA Kit for Mouse APAF-1

Cat.:

U1054m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse APAF-1

Cat.:

U1054h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse APAF-1

Cat.:

U1054r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Mouse APAF-1

Cat.:

U1054d

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96T

Polyclonal Antibody for Mouse APAF-1

Cat.:

P1054Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse APAF-1

Cat.:

P1054Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse APAF-1

Cat.:

P1054Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse APAF-1

Protein for Mouse APAF-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development."
Cecconi F. , Alvarez-Bolado G. , Meyer B.I. , Roth K.A. , Gruss P.
Cell94:727-737(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: Swiss Webster / NIH.
tissue: Embryo.
2.

"A comparison of the expression and properties of Apaf-1 and Apaf-1L."
Walke D.W. , Morgan J.I.
Brain Res.886:73-81(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue: Spleen.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
4.

"Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein."
Cho D.-H. , Hong Y.-M. , Lee H.-J. , Woo H.-N. , Pyo J.-O. , Mak T.W. , Jung Y.-K.
J. Biol. Chem.279:39942-39950(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APIP;DOMAIN
5.

"Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis."
Sakai T. , Liu L. , Teng X. , Mukai-Sakai R. , Shimada H. , Kaji R. , Mitani T. , Matsumoto M. , Toida K. , Ishimura K. , Shishido Y. , Mak T.W. , Fukui K.
J. Biol. Chem.279:41131-41140(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UACA
6.

"Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis."
Reubold T.F. , Wohlgemuth S. , Eschenburg S.
Structure19:1074-1083(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS);WD REPEATS;SUBUNIT;MUTAGENESIS OF ARG-265

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