Gene name:
ARID1A(BAF250;BAF250A;C1orf4;OSA1;SMARCF1);
Protein name:
AT-rich interactive domain-containing protein 1A(ARID domain-containing protein 1A);
Alternative:
BRG1-associated factor 250(BAF250);B120;Osa homolog 1(hOSA1);BRG1-associated factor 250a(BAF250A);SWI/SNF complex protein p270;SWI-like protein;hELD;SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of SWI/SNF chromatin remodeling complexes, in some of which it can be mutually exclusive with ARID1B/BAF250B. Component of the BAF (SWI/SNF-A) complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the SWI/SNF-B (PBAF) complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Component of the SWI/SNF Brm complex, at least composed of SMARCA2/BRM/BAF190B, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, HDAC1, HDAC2, and RBAP4. Component of the SWI/SNF complex Brg1(I), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, and probably HDAC2 and RBAP4. Component of the SWI/SNF Brg1(II), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A and probably HDAC2 and RBAP4. Component of a SWI/SNF-like EPAFa complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A and MLLT1/ENL. Component of a SWI/SNF-like complex containing ARID1A/BAF250A and ARID1B/BAF250B. Interacts through its C-terminus with SMARCA2/BRM/BAF190B and SMARCA4/BRG1/BAF190A. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with SMARCC1/BAF155. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.
Function:
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MAAQVAPAAA | SSLGNPPPPP | PSELKKAEQQ | QREEAGGEAA | AAAAAERGEM |
100:
KAAAGQESEG | PAVGPPQPLG | KELQDGAESN | GGGGGGGAGS | GGGPGAEPDL |
150:
KNSNGNAGPR | PALNNNLTEP | PGGGGGGSSD | GVGAPPHSAA | AALPPPAYGF |
200:
GQPYGRSPSA | VAAAAAAVFH | QQHGGQQSPG | LAALQSGGGG | GLEPYAGPQQ |
250:
NSHDHGFPNH | QYNSYYPNRS | AYPPPAPAYA | LSSPRGGTPG | SGAAAAAGSK |
300:
PPPSSSASAS | SSSSSFAQQR | FGAMGGGGPS | AAGGGTPQPT | ATPTLNQLLT |
350:
SPSSARGYQG | YPGGDYSGGP | QDGGAGKGPA | DMASQCWGAA | AAAAAAAAAS |
400:
GGAQQRSHHA | PMSPGSSGGG | GQPLARTPQP | SSPMDQMGKM | RPQPYGGTNP |
450:
YSQQQGPPSG | PQQGHGYPGQ | PYGSQTPQRY | PMTMQGRAQS | AMGGLSYTQQ |
500:
IPPYGQQGPS | GYGQQGQTPY | YNQQSPHPQQ | QQPPYSQQPP | SQTPHAQPSY |
550:
QQQPQSQPPQ | LQSSQPPYSQ | QPSQPPHQQS | PAPYPSQQST | TQQHPQSQPP |
600:
YSQPQAQSPY | QQQQPQQPAP | STLSQQAAYP | QPQSQQSQQT | AYSQQRFPPP |
650:
QELSQDSFGS | QASSAPSMTS | SKGGQEDMNL | SLQSRPSSLP | DLSGSIDDLP |
700:
MGTEGALSPG | VSTSGISSSQ | GEQSNPAQSP | FSPHTSPHLP | GIRGPSPSPV |
750:
GSPASVAQSR | SGPLSPAAVP | GNQMPPRPPS | GQSDSIMHPS | MNQSSIAQDR |
800:
GYMQRNPQMP | QYSSPQPGSA | LSPRQPSGGQ | IHTGMGSYQQ | NSMGSYGPQG |
850:
GQYGPQGGYP | RQPNYNALPN | ANYPSAGMAG | GINPMGAGGQ | MHGQPGIPPY |
900:
GTLPPGRMSH | ASMGNRPYGP | NMANMPPQVG | SGMCPPPGGM | NRKTQETAVA |
950:
MHVAANSIQN | RPPGYPNMNQ | GGMMGTGPPY | GQGINSMAGM | INPQGPPYSM |
1000:
GGTMANNSAG | MAASPEMMGL | GDVKLTPATK | MNNKADGTPK | TESKSKKSSS |
1050:
STTTNEKITK | LYELGGEPER | KMWVDRYLAF | TEEKAMGMTN | LPAVGRKPLD |
1100:
LYRLYVSVKE | IGGLTQVNKN | KKWRELATNL | NVGTSSSAAS | SLKKQYIQCL |
1150:
YAFECKIERG | EDPPPDIFAA | ADSKKSQPKI | QPPSPAGSGS | MQGPQTPQST |
1200:
SSSMAEGGDL | KPPTPASTPH | SQIPPLPGMS | RSNSVGIQDA | FNDGSDSTFQ |
1250:
KRNSMTPNPG | YQPSMNTSDM | MGRMSYEPNK | DPYGSMRKAP | GSDPFMSSGQ |
1300:
GPNGGMGDPY | SRAAGPGLGN | VAMGPRQHYP | YGGPYDRVRT | EPGIGPEGNM |
1350:
STGAPQPNLM | PSNPDSGMYS | PSRYPPQQQQ | QQQQRHDSYG | NQFSTQGTPS |
1400:
GSPFPSQQTT | MYQQQQQNYK | RPMDGTYGPP | AKRHEGEMYS | VPYSTGQGQP |
1450:
QQQQLPPAQP | QPASQQQAAQ | PSPQQDVYNQ | YGNAYPATAT | AATERRPAGG |
1500:
PQNQFPFQFG | RDRVSAPPGT | NAQQNMPPQM | MGGPIQASAE | VAQQGTMWQG |
1550:
RNDMTYNYAN | RQSTGSAPQG | PAYHGVNRTD | EMLHTDQRAN | HEGSWPSHGT |
1600:
RQPPYGPSAP | VPPMTRPPPS | NYQPPPSMQN | HIPQVSSPAP | LPRPMENRTS |
1650:
PSKSPFLHSG | MKMQKAGPPV | PASHIAPAPV | QPPMIRRDIT | FPPGSVEATQ |
1700:
PVLKQRRRLT | MKDIGTPEAW | RVMMSLKSGL | LAESTWALDT | INILLYDDNS |
1750:
IMTFNLSQLP | GLLELLVEYF | RRCLIEIFGI | LKEYEVGDPG | QRTLLDPGRF |
1800:
SKVSSPAPME | GGEEEEELLG | PKLEEEEEEE | VVENDEEIAF | SGKDKPASEN |
1850:
SEEKLISKFD | KLPVKIVQKN | DPFVVDCSDK | LGRVQEFDSG | LLHWRIGGGD |
1900:
TTEHIQTHFE | SKTELLPSRP | HAPCPPAPRK | HVTTAEGTPG | TTDQEGPPPD |
1950:
GPPEKRITAT | MDDMLSTRSS | TLTEDGAKSS | EAIKESSKFP | FGISPAQSHR |
2000:
NIKILEDEPH | SKDETPLCTL | LDWQDSLAKR | CVCVSNTIRS | LSFVPGNDFE |
2050:
MSKHPGLLLI | LGKLILLHHK | HPERKQAPLT | YEKEEEQDQG | VSCNKVEWWW |
2100:
DCLEMLRENT | LVTLANISGQ | LDLSPYPESI | CLPVLDGLLH | WAVCPSAEAQ |
2150:
DPFSTLGPNA | VLSPQRLVLE | TLSKLSIQDN | NVDLILATPP | FSRLEKLYST |
2200:
MVRFLSDRKN | PVCREMAVVL | LANLAQGDSL | AARAIAVQKG | SIGNLLGFLE |
2250:
DSLAATQFQQ | SQASLLHMQN | PPFEPTSVDM | MRRAARALLA | LAKVDENHSE |
2285:
FTLYESRLLD | ISVSPLMNSL | VSQVICDVLF | LIGQS

Vaild Sequence:
Related Databases
Uniprot: