BAK1 CLIA Kit for Human(Homo sapiens) | EIAab.comBAK1 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > BAK1(Gene name) > Human

BAK1 (Gene name),

Bcl-2 homologous antagonist/killer (Protein name ), BAK_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BAK1(BAK;BCL2L7;CDN1);

Protein name:

Bcl-2 homologous antagonist/killer;

Alternative:

Bcl-2-like protein 7(Bcl2-L-7);Apoptosis regulator BAK;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with BCL2A1 (By similarity). Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L.

Function:

In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.

Subcellular Location:

Mitochondrion membrane Single-pass membrane protein

Protein Attributes:

Sequence length:

211

Sequence:

50:

100:

150:

200:

211:

GQFVVRRFFK | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q16611

STRING:

9606.ENSP00000363591

KEGG:

hsa:578

MIM:

600516

String:

Q16611

Pfam:

PF00452

UniGene:

Hs.485139

Uniprot:

Q16611

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ELISA Kit for Human Bcl-2 homologous antagonist/killer

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E9626h

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96T

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ELISA Kit for Human Bcl-2 homologous antagonist/killer

Cat.:

E9626m

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96T

CLIA Kit for Human Bcl-2 homologous antagonist/killer

Cat.:

U9626m

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96T

CLIA Kit for Human Bcl-2 homologous antagonist/killer

Cat.:

U9626h

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96T

Polyclonal Antibody for Human Bcl-2 homologous antagonist/killer

Cat.:

P9626Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Bcl-2 homologous antagonist/killer

Cat.:

P9626Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Bcl-2 homologous antagonist/killer

Protein for Human Bcl-2 homologous antagonist/killer

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K."
Farrow S.N. , White J.H.M. , Martinou I. , Raven T. , Pun K.-T. , Grinham C.J. , Martinou J.-C. , Brown R.
Nature374:731-733(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: B-cell.
2.

"Induction of apoptosis by the Bcl-2 homologue Bak."
Chittenden T. , Harrington E.A. , O'Connor R. , Flemington C. , Lutz R.J. , Evan G.I. , Guild B.C.
Nature374:733-736(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak."
Kiefer M.C. , Brauer M.J. , Powers V.C. , Wu J.J. , Umansky S.R. , Tomei L.D. , Barr P.J.
Nature374:736-739(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

NIEHS SNPs program
Submitted (2003-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-28 AND ARG-69
5.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Brain.
tissue: Lung.
9.

"Estrogen alters expression of apoptosis-regulators, Bcl-2, Bcl-xL and Bak, as well as susceptibility to therapeutic agents of human breast cancer cells."
Eguchi H. , Hayashi S.
Submitted (1996-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 96-206
10.

"A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions."
Chittenden T. , Flemington C. , Houghton A.B. , Ebb R.G. , Gallo G.J. , Elangovan B. , Chinnadurai G. , Lutz R.J.
EMBO J.14:5589-5596(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS;FUNCTION OF BH3 MOTIF
11.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Human Bop is a novel BH3-only member of the Bcl-2 protein family."
Zhang X. , Weng C. , Li Y. , Wang X. , Jiang C. , Li X. , Xu Y. , Chen Q. , Pan L. , Tang H.
Protein Cell3:790-801(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BOP/C22ORF29
14.

"Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis."
Sattler M. , Liang H. , Nettesheim D. , Meadows R.P. , Harlan J.E. , Eberstadt M. , Yoon H.S. , Shuker S.B. , Chang B.S. , Minn A.J. , Thompson C.B. , Fesik S.W.
Science275:983-986(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 72-87 IN COMPLEX WITH BCL2L1 ISOFORM BCL-X(L)
15.

"The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site."
Moldoveanu T. , Liu Q. , Tocilj A. , Watson M. , Shore G. , Gehring K.
Mol. Cell24:677-688(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) OF 16-186;FUNCTION;SUBUNIT;MUTAGENESIS OF HIS-164;ZINC-BINDING
16.

"A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak."
Kvansakul M. , van Delft M.F. , Lee E.F. , Gulbis J.M. , Fairlie W.D. , Huang D.C.S. , Colman P.M.
Mol. Cell25:933-942(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 67-92 IN COMPLEX WITH MYXOMA VIRUS PROTEIN M11L
17.

"Crystal structure of MS0836."
RIKEN structural genomics initiative (RSGI)
Submitted (2008-04) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)

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